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1661por Liu, Derong, Fan, Baoyou, Li, Jinze, Sun, Tao, Ma, Jun, Zhou, Xianhu, Feng, Shiqing“…This review discusses the latest progress in the dynamic regulation of m6A modification, including methyltransferases (“writers”), demethylases (“erasers”) and m6A -binding proteins (“readers”). …”
Publicado 2022
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1662por Adamopoulos, Panagiotis G., Athanasopoulou, Konstantina, Daneva, Glykeria N., Scorilas, Andreas“…Ultimately, the involvement of the RNA modifications and their writers, erasers, and readers in human diseases and cancer is also discussed.…”
Publicado 2023
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1663“…This review presents the role of writers, readers, and erasers of DNA methylation and histone methylation, and acetylation in hematologic malignancies. …”
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1664“…Age-related epigenetic changes such as DNA methylation in the retina and optic nerve are accelerated in pathogenic conditions such as glaucoma and macular degeneration, but reversing these epigenetic marks may represent a novel therapeutic target. Epigenetic writers also integrate environmental signals such as hypoxia, inflammation, and hyperglycemia in complex retinal conditions such as diabetic retinopathy (DR) and choroidal neovascularization (CNV). …”
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1665“…These enzymes are defined as “writers”, “readers” and “erasers”. m6A and m5C are the most studied epigenetic modifications in RNA. …”
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1666por Liu, Ziying, Gao, Lei, Cheng, Long, Lv, Gaoyuan, Sun, Bei, Wang, Gang, Tang, Qiushi“…This posttranscriptional RNA modification is reversible and regulated by methyltransferase “writers” and demethylase “erasers”. The fate of m6A-modified RNAs depends on the function of different “readers” that recognize and bind to them. …”
Publicado 2023
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1667“…To create this narrative structure, we urge writers to consider starting at the end of their study, starting with writing their main conclusions, which provide the basis of the Discussion, and then work backwards: Results → Methods → refine the Discussion → Introduction → Abstract → Title. …”
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1668por Jain, Kanishk, Marunde, Matthew R, Burg, Jonathan M, Gloor, Susan L, Joseph, Faith M, Poncha, Karl F, Gillespie, Zachary B, Rodriguez, Keli L, Popova, Irina K, Hall, Nathan W, Vaidya, Anup, Howard, Sarah A, Taylor, Hailey F, Mukhsinova, Laylo, Onuoha, Ugochi C, Patteson, Emily F, Cooke, Spencer W, Taylor, Bethany C, Weinzapfel, Ellen N, Cheek, Marcus A, Meiners, Matthew J, Fox, Geoffrey C, Namitz, Kevin EW, Cowles, Martis W, Krajewski, Krzysztof, Sun, Zu-Wen, Cosgrove, Michael S, Young, Nicolas L, Keogh, Michael-Christopher, Strahl, Brian D“…Here, we show that H3 tail acetylation promotes nucleosomal accessibility to other H3K4 methyl readers, and importantly, extends to H3K4 writers, notably methyltransferase MLL1. This regulation is not observed on peptide substrates yet occurs on the cis H3 tail, as determined with fully-defined heterotypic nucleosomes. …”
Publicado 2023
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1669por Skar, Gustaf B., Graham, Steve, Huebner, Alan, Kvistad, Anne Holten, Johansen, Marita Byberg, Aasen, Arne Johannes“…The current study examined the effectiveness of a writing is caught approach with young developing writers in Norway. This method is based on the premise that writing competence is acquired naturally through real use in meaningful contexts. …”
Publicado 2023
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1670por Charatcharoenwitthaya, Natthinee, Jaisamrarn, Unnop, Songpatanasilp, Thawee, Kuptniratsaikul, Vilai, Unnanuntana, Aasis, Sritara, Chanika, Nimitphong, Hataikarn, Wattanachanya, Lalita, Chotiyarnwong, Pojchong, Amphansap, Tanawat, Phruetthiphat, Ong-Art, Valleenukul, Thanut, Chaiamnuay, Sumapa, Petchlorlian, Aisawan, Srinonprasert, Varalak, Tejavanija, Sirakarn, Kitisomprayoonkul, Wasuwat, Dajpratham, Piyapat, Chaikittisilpa, Sukanya, Somboonporn, Woraluk“…Evidence was searched using the MEDLINE database through PubMed. Primary writers submitted their first drafts, which were reviewed, discussed, and integrated into the final document. …”
Publicado 2023
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1671“…Modulation of m6A by readers, writers, and erasers (RWE) impacts mRNA processing, translation, nuclear export, localization, and degradation. …”
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1672“…RESULTS: Our research shows that the use of the metaphor “reproductive treatment” and its hidden messages depends on the writers’ intention and the target population. Although the phenomenon of patients travelling for reproductive treatment can fit into the definitions of tourism, the term emphasizes aspects that do not reflect patients’ reality. …”
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1673“…Plagiarism has become more common in both dental and medical communities. Most of the writers do not know that plagiarism is a serious problem. …”
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1674por Anelli, Filomena, Peters-Founshtein, Gregory, Shreibman, Yaen, Moreh, Elior, Forlani, Chiara, Frassinetti, Francesca, Arzy, Shahar“…We tested (1) patients with left-neglect and healthy participants, who are (2) left-to-right or right-to-left readers/writers, using (3) a lateralized left-right button press or a vocal mode in response to a mental time task, which asks participants to judge whether events have already happened in the past or are still to happen in the future. …”
Publicado 2018
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1675Barriers and facilitators to writing quality items for medical school assessments – a scoping review“…CONCLUSIONS: Although studies identified factors that may improve or negatively impact on the quality of items written by faculty and clinicians, there was limited research investigating the barriers and facilitators for individual item writers. Investigating these challenges could lead to more targeted and effective interventions to improve both the quality and quantity of assessment items.…”
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1676“…Therefore, this study analyzed the role of motivation in writing in developing writers, by examining the motives to write of 321 sixth graders. …”
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1677por Hesp, Blair R., Arai, Katsuhisa, Chu, Magdalene Y. S., Chuah, Stefanie, Curameng, Jose Miguel B., Kamat, Sandeep, Ma, Zhigang, Sakko, Andrew, Fernandez, Hazel“…Recommendations are provided for encore presentations, applying the ICMJE authorship criteria in the context of regional cultural expectations, and the role of study sponsors and professional medical writers. Ongoing barriers to compliance with guidelines are also highlighted, and additional guidance is provided to support authors submitting manuscripts for publication. …”
Publicado 2019
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1678“…We conclude that a short, structured workshop can help improve the confidence and knowledge of pre- and postdoctoral writers, preparing them to better meet the writing challenges of their professional careers.…”
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1679“…We also found that Beijing Evening News, in general, provided more advice in their weather commentaries. Finally, writers who were prone to take an authoritative stance tended to increase their use of imperatives and “high-status” vocatives during extreme weather, whereas those who positioned themselves “with” their readers also used more imperatives, but did not change their vocative preferences.…”
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1680por Faller, Paul“…Then, taking our lead from the theology of Karl Rahner which allows us to take a cosmic view of Christian religious experience, and from various writers who apply such a view to different areas of Christian life, we attempt a synthesis of current theological thought. …”
Publicado 2020
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