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1681por Gallagher, Noelle“…As the century wore on, breast cancer in particular became an important literary device for exploring the dangers of feeling in women, with writers of both moralising treatises and sentimental novels connecting the growth or development of cancer with the indulgence of feeling, and portraying emotional self-control as the only possible form of resistance against the disease. …”
Publicado 2020
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1682por Destefanis, Eliana, Avşar, Gülben, Groza, Paula, Romitelli, Antonia, Torrini, Serena, Pir, Pınar, Conticello, Silvestro G., Aguilo, Francesca, Dassi, Erik“…In mRNAs the deposition, removal, and recognition of chemical marks by writers, erasers and readers influence their structure, localization, stability, and translation. …”
Publicado 2021
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1683“…It is a dynamic and reversible process in mammalian cells, which is installed by “writers,” consisting of METTL3, METTL14, WTAP, RBM15/15B, and KIAA1429 and removed by “erasers,” including FTO and ALKBH5. …”
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1684por Tong, Jiyu, Wang, Xuefei, Liu, Yongbo, Ren, Xingxing, Wang, Anmin, Chen, Zonggui, Yao, Jiameng, Mao, Kaiqiong, Liu, Tingting, Meng, Fei-Long, Pan, Wen, Zou, Qiang, Liu, Jun, Zhou, Yu, Xia, Qiang, Flavell, Richard A., Zhu, Shu, Li, Hua-Bing“…Here, we identified major m(6)A “writers” as the top candidate genes regulating macrophage activation by LPS in an RNA binding protein focused CRISPR screening. …”
Publicado 2021
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1685por Abdullah, Omeima, Omran, Ziad, Hosawi, Salman, Hamiche, Ali, Bronner, Christian, Alhosin, Mahmoud“…Indeed, UHRF1 interacts with epigenetic writers, such as DNA methyltransferase 1 (DNMT1), histone methyltransferase G9a, erasers like histone deacetylase 1 (HDAC1), and functions as a hub protein. …”
Publicado 2021
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1686“…In conjunction with archaeological evidences for the manufacture of Egyptian blue in Cumae and Liternum and the concordant statements of the antique Roman writers Vitruvius and Pliny the Elder, natural impurities of the quartz sand speak for a pigment produced at the northern Phlegrean Fields (Campania, Southern Italy). …”
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1687“…N (6)-methyladenosine (m(6)A) is the most common internal modification to eukaryotic mRNA, which is involved in the splicing, stability, export, and degradation of RNA metabolism. m(6)A methylated-related genes are divided into writers, erasers, and readers, and they are critical for the regulation of cell life. …”
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1688“…The m6A modification is predominantly regulated by 3 tiers of protein modulators classified as writers, erasers, and readers. Depending upon cellular needs, these proteins function to deposit, remove, or read the methyl modifications on cognate mRNAs. …”
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1689“…The N6-methyladenosine (m6A) modification is the most abundant posttranscriptional mRNA modification in mammalian cells and is dynamically modulated by a series of “writers,” “erasers,” and “readers.” Studies have shown that m6A affects RNA metabolism in terms of RNA processing, nuclear export, translation, and decay. …”
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1690“…Such modifications are deposited by methyltransferases (i.e., m(6)A Writers), removed by demethylases (i.e., m(6)A Erasers), and recognized by m(6)A binding proteins (i.e., m(6)A Readers). …”
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1691por Faravelli, Giulia, Mondani, Valentina, Mangione, P. Patrizia, Raimondi, Sara, Marchese, Loredana, Lavatelli, Francesca, Stoppini, Monica, Corazza, Alessandra, Canetti, Diana, Verona, Guglielmo, Obici, Laura, Taylor, Graham W., Gillmore, Julian D., Giorgetti, Sofia, Bellotti, Vittorio“…Whereas the process of metamorphosis has inspired poets and writers from Ovid to Kafka, protein metamorphism is a more recent concept. …”
Publicado 2022
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1692“…Thus, the results corroborate a monopolised pigment production site located in the northern Phlegrean Fields persisting over the first centuries A.D., this in line with statements of the antique Roman writers Vitruvius and Pliny the Elder and recent archaeological evidences. …”
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1693por Thaler, Roman, Khani, Farzaneh, Sturmlechner, Ines, Dehghani, Sharareh S., Denbeigh, Janet M., Zhou, Xianhu, Pichurin, Oksana, Dudakovic, Amel, Jerez, Sofia S., Zhong, Jian, Lee, Jeong-Heon, Natarajan, Ramesh, Kalajzic, Ivo, Jiang, Yong-hui, Deyle, David R., Paschalis, Eleftherios P., Misof, Barbara M., Ordog, Tamas, van Wijnen, Andre J.“…Importantly, deletion of 5hmC-writers, Tet1 and Tet2, in Vitamin C-sufficient murine bone causes severe skeletal defects which mimic bone phenotypes of Vitamin C-insufficient Gulo knockout mice, a model of Vitamin C deficiency and scurvy. …”
Publicado 2022
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1694por Vinson, David A., Stephens, Kimberly E., O’Meally, Robert N., Bhat, Shri, Dancy, Blair C. R., Cole, Robert N., Yegnasubramanian, Srinivasan, Taverna, Sean D.“…Epigenetic modifications to histone proteins serve an important role in regulating permissive and repressive chromatin states, but despite the identification of many histone PTMs and their perceived role, the epigenetic writers responsible for generating these chromatin signatures are not fully characterized. …”
Publicado 2022
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1695“…Quantitative results manifest significantly higher metadiscursive frequencies in English-medium RAs than in Chinese-medium RAs, and significantly higher metadiscursive frequencies in RAs written by British-American scholars than by Chinese scholars. Also, Chinese ESL writers reveal L1-based transfer of discourse conceptualization. …”
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1696por Xiao, Qiufeng, Wu, Xunyao, Deng, Chuiwen, Zhao, Lidan, Peng, Linyi, Zhou, Jiaxin, Zhang, Wen, Zhao, Yan, Fei, Yunyun“…The mRNA levels of m6A writers (METTL3 and WTAP) and readers (YTHDF2, YTHDF3, and YTHDC2) were lower in PBMCs from patients with pSS compared to patients with non-SS sicca. …”
Publicado 2022
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1698“…The authors, veteran science writers with special expertise in physics and engineering, have created a lively narrative that interweaves rich biographical detail from each man's life with clear explanations of their scientific accomplishments. …”
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1699“…Phrases such as multiverses, quantum leaps, alternate universes, the uncertainty principle, and Schrödinger's cat get reinvented continually in cartoons and movies, coffee mugs and T-shirts, and fiction and philosophy, reinterpreted by each new generation of artists and writers. Is a "quantum leap" big or small? How uncertain is the uncertainty principle? …”
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1700por Watson, Peter“…In the early decades of the twentieth century, German artists, writers, scholars, philosophers, scientists, and engineers were leading their freshly unified country to new and unimagined heights. …”
Publicado 2010
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