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1741“…Modifications to the epigenome are driven by an array of epigenetic enzymes generally referred to as writers, erasers and readers that define cellular fate and destiny. …”
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1742por Larrow, Annie, Chong, Amy, Robison, Treavor, Patel, Aarti, Kuelbs, Cynthia, Fisher, Erin, Hershey, Daniel, Pierce, Heather“…Notable changes to the template included embedded writing tips to guide writers and specific template choices for common diagnoses to standardize content. …”
Publicado 2021
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1743por Feng, Yang, Chen, Juan-Juan, Xie, Neng-Bin, Ding, Jiang-Hui, You, Xue-Jiao, Tao, Wan-Bing, Zhang, Xiaoxue, Yi, Chengqi, Zhou, Xiang, Yuan, Bi-Feng, Feng, Yu-Qi“…DNA cytosine methylation (5-methylcytosine, 5mC) is the most important epigenetic mark in higher eukaryotes. 5mC in genomes is dynamically controlled by writers and erasers. DNA (cytosine-5)-methyltransferases (DNMTs) are responsible for the generation and maintenance of 5mC in genomes. …”
Publicado 2021
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1744“…This chemical marker of RNA is produced by m(6)A ‘writers’ (methylase) and can be degraded by m(6)A ‘erasers’ (demethylase). …”
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1745“…As the world entered the 21st century, Sports Illustrated writers, Oscar Johnson and Ron Fimrite, offered their visions of sport in the year 2001. …”
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1746por Ge, Yong, Ling, Tao, Wang, Yao, Jia, Xin, Xie, Xiongmei, Chen, Rong, Chen, Shangwu, Yuan, Shaochun, Xu, Anlong“…Here, we reveal that WT1‐associated protein (WTAP), one of the m(6)A “writers”, is degraded via the ubiquitination‐proteasome pathway upon activation of IFN‐I signaling. …”
Publicado 2021
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1747por Bonitto, Kenya, Sarathy, Kirthana, Atai, Kaiser, Mitra, Mithun, Coller, Hilary A.“…We consider different model systems for quiescence, each of the most frequently monitored candidate histone marks, and the role of their writers, erasers and readers. We highlight data that support these marks contributing to the changes observed with quiescence. …”
Publicado 2021
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1748por McCall, Becky, Shallcross, Laura, Wilson, Michael, Fuller, Chris, Hayward, Andrew“…ST techniques included digital ST (DST), written ST, verbal ST, and use of professional writers. Of the ten studies, seven used ST to change KAB/P; the remainder used ST to extract insights. …”
Publicado 2021
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1749por Huang, Mei, Xu, Shaozhe, Liu, Lifei, Zhang, Miao, Guo, Jianmin, Yuan, Yu, Xu, Jiake, Chen, Xi, Zou, Jun“…N6 methyladenosine (m6A) is a methylated adenosine nucleotide, which functions through its interaction with the proteins called “writers,” “readers” and “erasers.” The epigenetic regulation of m6A has been demonstrated to affect mRNA processing, nuclear export, translation, and splicing. …”
Publicado 2021
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1750“…This dynamic process is regulated by methylases (editors/writers), demethylases (remover/erasers), and proteins that recognize methylation (effectors/readers). …”
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1751“…APPROACH: Our method for analyzing the strategies was conceptual analysis since the development of technology is embedded with conceptual ideas of humanity, explicit or implicit, and in addition to deepening analysis of explicit argumentation the method enables the deconstruction and reconstruction of meanings and conceptual relations within the strategies, exposing presumptions and tacit commitments of the writers. FINDINGS: The analysis of the documents illustrates that the general tendency in national strategies is globally dominantly technology-driven as the state of affairs appears to be creating new technologies. …”
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1752por Gabius, Hans‐Joachim, Cudic, Maré, Diercks, Tammo, Kaltner, Herbert, Kopitz, Jürgen, Mayo, Kevin H., Murphy, Paul V., Oscarson, Stefan, Roy, René, Schedlbauer, Andreas, Toegel, Stefan, Romero, Antonio“…The enzymatic machinery for glycan biosynthesis (writers) realizes this enormous potential for building a large vocabulary. …”
Publicado 2021
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1753“…By using BioCRNpyler, users ranging from expert modelers to novice script-writers can easily build, manage, and explore sophisticated biochemical models using diverse biochemical implementations, environments, and modeling assumptions.…”
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1754por Liu, Chi, Gu, Lei, Deng, Wenjuan, Meng, Qianchao, Li, Nan, Dai, Guifeng, Yu, Suli, Fang, Hong“…N6-methyladenosine (m6A) modification is the most universal and abundant post-transcriptional modification of eukaryotic RNA and occurs mainly at the consensus motif RR (m6A) CH (R = A or G, H = A, C, or U) in long internal exons, near stop codons, or in the 3′ untranslated region (UTR). “Writers,” “erasers,” and “readers” are responsible for the occurrence, removal, and recognition of m6A modification, respectively. …”
Publicado 2022
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1755por Qu, Wenzheng, Li, Qian, Wang, Mengxuan, Zhao, Xingsen, Wu, Jiangdong, Liu, Diwen, Hong, Shenghui, Yang, Ying, Shu, Qiang, Li, Xuekun“…Notably, EE exposure decreased the protein level of m(6)A eraser Fto, but did not affect the protein level of m(6)A writers METTL3 and METTL14. Taken together, our results suggest that enriched environment exposure induces differential m(6)A mRNA modification and adds a novel layer to the interaction between the environment and epigenetics in the context of postnatal neuronal development.…”
Publicado 2022
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1756“…During the data analysis, the relevant sources of publications, relevant keywords, productive writers based on publications and citations, top articles based on citations received, and regions actively engaged in research into machine learning applications for concrete were identified. …”
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1757por Xiao, Zhuoyu, Liu, Sun, Li, Zengguang, Cui, Jinru, Wang, Hailan, Wang, Zihan, Ren, Qihuan, Xia, Laixin, Wang, Zhijian, Li, Yuan“…Here, we found that loss of the maternal microbiome altered the expression of m(6)A writers and erasers, as well as the m(6)A methylome of the mouse fetal brain and intestine on embryonic day 18. …”
Publicado 2022
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1758por Jin, Yanrui“…British and American romantic writers wrote their own ecological consciousness from three aspects: natural aesthetic and spiritual significance, simple ecological environmental protection consciousness, and life community. …”
Publicado 2022
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1759por Chen, Sai, Ren, Hefei, Zhang, Xiaomin, Chang, Liu, Wang, Zhenhua, Wu, Hongkun, Zhang, Jiafeng, Ren, Jigang, Zhou, Lin“…BACKGROUND: N6‐methyladenosine (m6A) is the addition of a methyl group on the N6 position of adenosine and is the most prevalent and abundant epigenetic modification in eukaryote mRNA. m6A marks are added to mRNA by the m6A methyltransferase complex (“writers”), removed by m6A demethylases (“erasers”), and recognized by m6A‐binding proteins (“readers”). …”
Publicado 2022
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1760por Buchanan, April O., Strano-Paul, Lisa, Saudek, Kris, Lupi, Carla, Jones, Lee, Wagner, Mary Jo, Elliott, Donna“…A variety of stakeholders affirmed that these workshops have value in training writers to improve their narrative comments for the MSPE.…”
Publicado 2022
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