“…Due to the reversible and dynamic regulatory network composed of ‘writers’ (methylase), ‘erasers’ (demethylase) and ‘readers’ (m6A binding proteins), m6A has been deemed as an essential modulator in vast physiological and pathological processes. …”
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“…Although there are many reports demonstrating m(6)A participation in critical biological functions, this exploration has mainly been conducted through the global KO or knockdown of the writers, erasers, or readers of m(6)A. Consequently, there is a lack of information about the role of m(6)A on single transcripts in biological processes, posing a challenge in understanding the biological functions of m(6)A. …”
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“…Moreover, the identification and characterization of m(6)A writers, readers and erasers in Arabidopsis and other model crops have offered insights into the biological roles of m(6)A in plant abiotic stress responses. …”
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“…Owing to the multifaceted problems in which Ethiopia has been embroiled, such as war, displacement, and humanitarian crisis, writers arbitrarily use terms such as “state fragility,” “state failure,” and “state collapse” to represent the situation. …”
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“…The C++ package implements monitor service interface (IMonitorSvc) following the Gaudi specifications, with methods to declare variables and histograms for monitoring. Algorithms writers use them to indicate which quantities should be monitored. …”
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“…Saadat Hasan ‘Manto’ is widely acknowledged as one of the greatest short story writers in the world. He died at the age of forty three from complications of alcoholism. …”
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“…Methods: Ethnodrama performances were developed by script writers and a theatre director in collaboration with the investigators and BCS using data from published research and pre-performances workshops. …”
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“…In addition to their utility as anti-proliferative agents, the pharmacological inhibitors that target epigenetic regulators (referred to here as readers, writers, and erasers for their ability to recognize, deposit, and remove post-translational modifications) have the potential to reconfigure the epigenetic landscape of diseased cells and disrupt the cancerous phenotype. …”
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“…Tumor cells’ epitranscriptome is indeed disrupted in a way to promote cancer-prone features, by means of up/downregulating m(6)A-related players: the so-called writers, readers and erasers. These proteins modulate m(6)A establishment, removal and determine mRNAs fate, acting in a context-dependent manner, so that a single player may act as an oncogenic signal in one tumor model (methyltransferase like 3 (METTL3) in lung cancer) and as a tumor suppressor in another context (METTL3 in glioblastoma). …”
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“…The abundance and functions of RNA modifications are controlled mainly by the modification regulatory proteins: writers, erasers and readers. Modified RNA bases and their regulators form intricate networks which are associated with a vast array of diverse biological functions. …”
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“…In this review, we summarize the recent studies about RNA modifications, such as N(6)-methyladenosine (m(6)A), N(6),2′O-dimethyladenosine (m(6)A(m)), 5-methylcytosine (m(5)C), N(1)-methyladenosine (m(1)A), inosine (I) and pseudouridine (ψ) as well as the corresponding RMPs including the writers, erasers and readers that participate in the tumorigenesis and development of GBM, so as to provide some clues for GBM treatment.…”
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“…The chapter contends that such a condition of relation through difference can be better understood via a reading of form and mode of the novels of these events. It shows that writers have predominantly used the realist form to represent the long-term historical crisis, while they have employed a range of modes—from social realist, critical realist to metafictional, urban fantastic, gothic, and others (many of which are conventionally understood as anti-realist or non-realist). …”
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“…Medical and social science electronic databases, lists of publications and projects of the European, North American, Canadian, and Australian HTA agencies, as well as the bibliography of the identified articles and documents are looked through. The writers do a handsearch of the International Journal of Technology Assessment in Health Care and contact 64 HTA agencies by a letter, requesting information on investigations that might not have been published. …”
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“…Dicho abordaje regresa necesariamente a una época, un lugar y un contexto donde el progreso social y la formación del ciudadano poseían particular importancia.Palabras clave: Infancia, Control, Derechos, Anormalidad, Trabajo infantil  AbstractThis text analyzes different Argentine writers concerned with the theme of childhood in order to disaggregate the first years in which this, along with child labor theme acquired political interest and became a matter of social control. …”
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“…Overall, our patient population is representative of the broader group of MDEMs and includes mostly autosomal dominant disorders impacting writers more so than erasers, readers, and remodelers of chromatin marks. …”
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“…Only the BMJ offered conflicts of interest disclosures for prolific science writers in its website, but even then only 2 of the 25 massively prolific authors disclosed potential conflicts with some specificity. …”
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“…The most influential writers were Zhang and Wang from China and Mathiyalagan from the United States. …”
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“…Clinical practice is running well ahead of the guidelines because equipoise has been lost by physicians faced with patients for whom they have no other effective therapy. Guideline writers are correct in providing recommendations which are less strong for LAAC than for OACs, for those who are able and willing to take OAC treatment, but for those who are not, a stronger recommendation is needed. …”
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“…Like phosphorylation, palmitoylation is highly dynamic and tightly regulated by writers (i.e., palmitoyl acyltransferases) and erasers (i.e., depalmitoylating enzymes). …”
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“…Additionally, in silico analyses show that the signature correlates inversely with DNA methylation writers and with key biological processes involved in cancer progression, such as proliferation and stemness. …”
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