Mostrando 1 - 20 Resultados de 146 Para Buscar '"Wye"', tiempo de consulta: 0.24s Limitar resultados
  1. 1
    “…The title compound [systematic name: 3-(3,4-di­hydroxy­phen­yl)-5-hy­droxy-7-meth­oxy-4H-chromen-4-one monohydrate], C(16)H(12)O(6)·H(2)O, is a monohydrate of a natural product santal isolated from Wye­thia mollis. In the santal mol­ecule, the dihedral angle between the benzo­quinone and di­hydroxy­phenyl fragments is 53.9 (1)° and an intra­molecular O—H⋯O hydrogen bond occurs. …”
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    “…We evaluated the in vitro and in vivo antitumor efficacy of mTOR inhibitors, rapamycin and WYE-354. In vitro assays showed WYE-354 significantly reduced cell viability, migration and invasion and phospho-P70S6K expression in GBC cells. …”
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    “…We set out to evaluate the novel compound, [(125)I]WYE-230949, as a potential radionuclide imaging agent for the histamine H(3) receptor in brain. [(125)I]WYE-230949 had a high in vitro affinity for the rat histamine H(3) receptor (K(d) of 6.9 nM). …”
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    “…Furthermore, WYE-354 stimulated the ATPase activity of ABCB1, which was consistent with in silico predictions using a human ABCB1 mouse homology model, indicating that WYE-354 is a potent substrate of ABCB1. …”
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    Libro
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    Libro
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    “…We demonstrated that WYE-354 is a substrate of ABCB1, that the overexpression of the ABCB1 transporter decreases the efficacy of WYE-354, and that the resistant WYE-354 can be reversed by an ABCB1 inhibitor at a pharmacological achievable concentration. …”
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    “…We here tested the potential anti-RCC activity by a novel mTOR kinase inhibitor WYE-687in vitro and in vivo.WYE-687 was cytotoxic and anti-proliferative to established RCC cell lines (786-O and A498) and primary human RCC cells. …”
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    Publicado 1987
    Partituras Libro
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    Publicado 2004
    Libro
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    Libro
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