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  1. 1
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    xCas9 expands the scope of genome editing with reduced efficiency in rice
  2. 2
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    An engineered xCas12i with high activity, high specificity, and broad PAM range
  3. 3
    “…The recently developed xCas9-derived base editors (xBEs) that recognize the NG PAM substantially expand the targeting scope in the genome, while their editing efficiency needs to be improved. …”
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    Improving Editing Efficiency for the Sequences with NGH PAM Using xCas9-Derived Base Editors
  4. 4
    “…We also developed the corresponding xCas9-based cytosine base editor (CBE) that can edit the NG and GA PAM sites. …”
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    Genome Engineering in Plant Using an Efficient CRISPR-xCas9 Toolset With an Expanded PAM Compatibility
  5. 5
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    Expanding the base editing scope to GA and relaxed NG PAM sites by improved xCas9 system
  6. 6
    “…Le Guide du Calcul avec les logiciels libres vous propose de maîtriser les bases de plusieurs logiciels gratuits de calcul formel et numérique, et de géométrie dynamique : XCAS, Scilab, Bc, Gp, GnuPlot, Maxima, Octave, Yacas, et également MuPAD (non libre). …”
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    Guide du calcul avec les logiciels libres: XCAS, Scilab, Bc, Gp, GnuPlot, Maxima, MuPAD
  7. 7
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    Engineered xCas9 and SpCas9‐NG variants broaden PAM recognition sites to generate mutations in Arabidopsis plants
  8. 8
    “…Through determination of multiple xCas9 structures, which are all in complex with single-guide RNA (sgRNA) and double-stranded DNA containing different PAM sequences (TGG, CGG, TGA, and TGC), we decipher the molecular mechanisms of the PAM expansion and fidelity enhancement of xCas9. xCas9 follows a unique two-mode PAM recognition mechanism. …”
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    Molecular basis for the PAM expansion and fidelity enhancement of an evolved Cas9 nuclease
  9. 9
    “…SUMMARY ANSWER: PGT is not a preferred recommendation for women with XCAs in the absence of other PGT indications. WHAT IS KNOWN ALREADY: XCAs are the most frequent sort of chromosomal aberrations in infertile women. …”
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    Preimplantation genetic testing is not a preferred recommendation for patients with X chromosome abnormalities
  10. 10
    “…[Image: see text] Inorganic nanoscale X-ray contrast agents (XCAs) offer many potential advantages over currently used intravascular molecular contrast agents, including longer circulation and retention times, lower administration volumes, and greater potential for site directed imaging. …”
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    Synthesis, X-ray Opacity, and Biological Compatibility of Ultra-High Payload Elemental Bismuth Nanoparticle X-ray Contrast Agents
  11. 11
    “…In this study, by analyzing 16 gene-edited rabbit lines (including 112 rabbits) generated using SpCas9, BEs, xCas9, and xCas9-BEs with long-range PCR genotyping and long-read sequencing by the PacBio platform, we show the extension of thousands of base fragment deletions in single-guide RNA/Cas9 and xCas9 system mutation rabbits, but no deletions were found in BE-induced mutation rabbits. …”
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    Large-Fragment Deletions Induced by Cas9 Cleavage while Not in the BEs System
  12. 12
    “…Of the PAM-flexible variants, we find that Cas9-NG outperforms xCas9 regardless of genome engineering modality or PAM. …”
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    High-Throughput Screens of PAM-Flexible Cas9 Variants for Gene Knockout and Transcriptional Modulation
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    “…Compared to those in wild-type (WT) SpCas9, REC2 and REC3 domains in xCas9 3.7 undergo striking conformational changes, leading to reduced contact with DNA substrate. …”
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    Structural insights into a high fidelity variant of SpCas9
  14. 14
    “…Here we used phage-assisted continuous evolution (PACE) to evolve an expanded PAM SpCas9 variant (xCas9) that can recognize a broad range of PAM sequences including NG, GAA, and GAT. …”
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    Evolved Cas9 variants with broad PAM compatibility and high DNA specificity
  15. 15
    “…The use of CRISPR/LbCpf1 and CRISPR/xCas9 systems in wheat have not yet been reported. …”
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    Efficient induction of haploid plants in wheat by editing of TaMTL using an optimized Agrobacterium-mediated CRISPR system
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    “…CONCLUSIONS: The mutation of ITSM in cytotoxic T cell via the ABE-xCas9 system can significantly enhance the antitumor activity of T cells.…”
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    Mutation of PD-1 immune receptor tyrosine-based switch motif (ITSM) enhances the antitumor activity of cytotoxic T cells
  17. 17
    “…Recently, SpCas9 variants (i.e., xCas9 3.7, SpCas9-NG, and SpRY) were developed that recognise the NG dinucleotide or almost any other PAM sequences in human cell lines. …”
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    Knock-in and precise nucleotide substitution using near-PAMless engineered Cas9 variants in Dictyostelium discoideum
  18. 18
    “…We showed that the range of editable loci in the wheat genome could be further expanded by using the engineered variants of Cas12a (LbCas12a‐RVR) and Cas9 (Cas9‐NG and xCas9) that recognize the TATV and NG PAMs, respectively, with the Cas9‐NG showing higher editing efficiency on the targets with atypical PAMs compared to xCas9. …”
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    Expanding the range of editable targets in the wheat genome using the variants of the Cas12a and Cas9 nucleases
  19. 19
    “…We show that XCAS9 and dCAS9 also interact with KU86 and disrupt DNA DSB repair. …”
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    CAS9 is a genome mutator by directly disrupting DNA-PK dependent DNA repair pathway
  20. 20
    “…We discuss the biological mechanisms of CRISPR-Cas as immune defense systems, recently-discovered anti-CRISPR-Cas systems, and the emerging Cas variants (such as xCas9 and Cas13) with unique characteristics. Then, we highlight various CRISPR-Cas biotechnologies, including nuclease-dependent genome editing, CRISPR gene regulation (including CRISPR interference/activation), DNA/RNA base editing, and nucleic acid detection. …”
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    CRISPR-Cas9/Cas12a biotechnology and application in bacteria
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