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  1. 1421
    “…We used phylogenetics to select transporters for expression in Xenopus laevis oocytes to screen for transport activities. …”
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    Electrophysiological characterization of a diverse group of sugar transporters from Trichoderma reesei
  2. 1422
    “…The functional effect of the Q457R mutation was determined in protein expressed in Xenopus laevis oocytes using biophysical and biochemical methods. …”
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    The Molecular Basis of Glucose Galactose Malabsorption in a Large Swedish Pedigree
  3. 1423
    “…Using a combination of parasite assays and heterologous characterisation of TgApiAT6-1 in Xenopus laevis oocytes, we demonstrate that TgApiAT6-1 is a general cationic amino acid transporter that mediates both the high-affinity uptake of lysine and the low-affinity uptake of arginine. …”
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    Coordinated action of multiple transporters in the acquisition of essential cationic amino acids by the intracellular parasite Toxoplasma gondii
  4. 1424
    “…Functional characterization of this mutant channel in Xenopus laevis oocytes demonstrated that its electrophysiological properties differed from those of polycystin-2 and instead resembled the properties of polycystin-2L1, in particular regarding its permeability for Ca(2+) ions. …”
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    A polycystin-2 protein with modified channel properties leads to an increased diameter of renal tubules and to renal cysts
  5. 1425
    “…In the present study, we show that the expression of mouse TMEM175 results in very small K(+) currents through the plasma membrane in Xenopus laevis oocytes, in good accordance with the previously reported intracellular localization of the channel. …”
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    Translocation of TMEM175 Lysosomal Potassium Channel to the Plasma Membrane by Dynasore Compounds
  6. 1426
    “…In vivo, TF was administered orally, and remyelination was assessed both in myelin basic protein–GFP-nitroreductase (Mbp:GFP-NTR) transgenic Xenopus laevis demyelinated by metronidazole and in adult mice demyelinated by lysolecithin. …”
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    Teriflunomide Promotes Oligodendroglial 8,9-Unsaturated Sterol Accumulation and CNS Remyelination
  7. 1427
    “…Xenopus laevis are able to regenerate the spinal cord during larvae stages through the activation of neural stem progenitor cells (NSPCs). …”
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    Analysis of the early response to spinal cord injury identified a key role for mTORC1 signaling in the activation of neural stem progenitor cells
  8. 1428
    “…The GluN2A inhibitory activities of the paracyclophane derivatives were tested with two‐electrode voltage clamp electrophysiology using Xenopus laevis oocytes expressing selectively functional NMDA receptors with GluN2A subunit. …”
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    [2.2]Paracyclophane‐Based TCN‐201 Analogs as GluN2A‐Selective NMDA Receptor Antagonists
  9. 1429
    “…METHODS: We quantified the effects of C99 on Kv channel function, using electrophysiological analysis of subunits expressed in Xenopus laevis oocytes, biochemical and immunofluorescence techniques. …”
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    The Amyloid Precursor Protein C99 Fragment Modulates Voltage-Gated Potassium Channels
  10. 1430
    “…[Image: see text] In immature oocytes, Balbiani bodies are conserved membraneless condensates implicated in oocyte polarization, the organization of mitochondria, and long-term organelle and RNA storage. In Xenopus laevis, Balbiani body assembly is mediated by the protein Velo1. …”
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    Clustering of Aromatic Residues in Prion-like Domains Can Tune the Formation, State, and Organization of Biomolecular Condensates: Published as part of the Biochemistry virtual special issue “Protein Condensates”
  11. 1431
    “…Herein, using two-electrode voltage clamp on Xenopus laevis oocytes, we demonstrate that SGK1.1 selectively activates heteromeric Kv7 subunit combinations underlying the M-current. …”
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    Activation of SGK1.1 Upregulates the M-current in the Presence of Epilepsy Mutations
  12. 1432
    “…To study the underlying disease mechanism, morpholino knock-down of zbtb26 in Xenopus laevis was carried out, which demonstrated significantly smaller thyroid anlagen in knock-down animals at tadpole stage. …”
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    Identification of ZBTB26 as a Novel Risk Factor for Congenital Hypothyroidism
  13. 1433
    “…The faradaic devices are prototyped by modulating human H(2)O(2)‐sensitive Kv7.2/7.3 (M‐type) channels expressed in a single‐cell model (Xenopus laevis oocytes). The Kv7 ion channel family is responsible for regulating neuronal excitability in the heart, brain, and smooth muscles, making it an ideal platform for faradaic ROS stimulation. …”
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    Faradaic Pixels for Precise Hydrogen Peroxide Delivery to Control M‐Type Voltage‐Gated Potassium Channels
  14. 1434
    “…We studied six frog species (Xenopus laevis, Rana pipiens, R. catesbeiana, Bufo boreas, Pseudacris cadaverina, and P. regilla) differing in ecological relationships to environmental water. …”
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    Physiological control of water exchange in anurans
  15. 1435
    “…To examine the emergence of topographically organized maps in the retinotectal system, we performed longitudinal visual receptive field mapping by calcium imaging in the optic tectum of GCaMP6-expressing transgenic Xenopus laevis tadpoles. At stage 42, just 1 d after retinal axons arrived in the optic tectum, a clear retinotopic azimuth map was evident. …”
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    Topographic map formation and the effects of NMDA receptor blockade in the developing visual system
  16. 1436
    “…Here, we present multiple crystal structures, including an open-like conformation, of σ(1)R from Xenopus laevis. Together with functional binding analysis our data suggest that access to the σ(1)R ligand binding site is likely achieved by protein conformational changes that involve the carboxy-terminal two-helix bundle, rather than structural changes in the cupin-fold domain.…”
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    An open-like conformation of the sigma-1 receptor reveals its ligand entry pathway
  17. 1437
    “…Finally, the activity was validated in voltage clamp studies on Xenopus laevis oocytes transiently expressing GABA(A) receptors of the α(1)β(2)γ(2)S and α(1)β(2) subtypes. …”
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    Clerodane Diterpenes from Casearia corymbosa as Allosteric GABA(A) Receptor Modulators
  18. 1438
    “…We previously demonstrated dm-W to be the SDG in the African clawed frog Xenopus laevis and found that a portion of this gene emerged from the masculinization gene dmrt1 after allotetraploidization by interspecific hybridization between two ancestral species around 17–18 Ma. dm-W has four exons consisting of a noncoding exon 1, dmrt1-derived exons 2 and 3, and an orphan exon 4 (Ex4) of unknown origin that includes coding sequence (CDS). …”
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    Neofunctionalization of a Noncoding Portion of a DNA Transposon in the Coding Region of the Chimerical Sex-Determining Gene dm-W in Xenopus Frogs
  19. 1439
    “…Here, we interrogated the parts of the PI(4,5)P(2) head group that mediate its interaction with TMEM16A by using patch- and two-electrode voltage-clamp recordings on oocytes from the African clawed frog Xenopus laevis, which endogenously express TMEM16A channels. …”
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    Phosphate position is key in mediating transmembrane ion channel TMEM16A–phosphatidylinositol 4,5-bisphosphate interaction
  20. 1440
    “…Furthermore, we find that Xenopus laevis nucleosomes can substitute for yeast ones in engaging with ORC. …”
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    Nucleosome-directed replication origin licensing independent of a consensus DNA sequence
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