“…Previously, we reported that H157Y, a rare coding variant on exon 3 of the triggering receptor expressed on myeloid cells 2 gene (TREM2), was associated with Alzheimer’s disease (AD) risk in a Han Chinese population. …”
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“…Among them, the role of P2X(7) receptors is especially well delineated, but P2X(4), various P2Y, A(1), A(2A) and A(3) receptors also powerfully participate in the microglial response. …”
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“…Nous présentons le cas d'une patiente de 70 ans ayant un antécédent d'acromégalie sur adénome hypophysaire il y a 25 ans, traitée chirurgicalement et déclarée en rémission complète, a développé une arthropathie destructrice des deux épaules. …”
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“…The devised synthetic strategy entailed a cascade Takai–Utimoto ester olefination/ring closing metathesis to construct ring Y, a hydroxydithioketal cyclization/methylation sequence to cast ring X, a Horner–Wadsworth–Emmons coupling of WXYZA′ ketophosphonate 11 with QRSTU aldehyde 12 to form enone 10, and a reductive hydroxyketone ring closure to forge ring V. 2D NMR spectroscopic analysis and comparison of (13)C chemical shifts with those of the corresponding carbons of maitotoxin revealed close similarities supporting the originally assigned structure of this region of the natural product. …”
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“…Since YidC is essential in membrane protein biogenesis and LacY a paradigm for the major facilitator superfamily, our observations have general relevance.…”
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“…This verification is carried out mechanically with KeY, a state-of-the-art interactive verification tool for Java. …”
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“…Hybrid membranes formed by co-assembly of A(x)B(y)A(x) (hydrophilic-hydrophobic-hydrophilic) triblock copolymers into lipid bilayers are investigated by dissipative particle dynamics. …”
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“…The class of so‐called nucleoside antibiotics furnishes promising candidates for the development of new antibiotics, as these compounds block a clinically unexploited bacterial target: the integral membrane protein MraY, a key enzyme in cell wall (peptidoglycan) biosynthesis. …”
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“…For this purpose, a VGG16 network was trained with the CT images (X). For the annotation (y) a new method for automated annotation, ‘surrogate’ learning, was introduced. …”
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“…Let [Image: see text] be a set of functions with a common domain X and a common range Y. A set [Image: see text] is called a set of range uniqueness (SRU) for [Image: see text] , if for all [Image: see text] , [Image: see text] Let [Image: see text] be the set of all real polynomials in n variables of degree at most k and let [Image: see text] be the set of all linear functions [Image: see text] with rank k. …”
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“…The highest and lowest values were seen in Uganda (64.13%) and Zimbabwe (6.08%). Women age 25-34y (aOR = 1.19; 95% CI 1.11, 1.29), 35–49y (aOR = 1.26; 95% CI 1.13, 1.41) as compared to 15–24 years, poorer (aOR = 1.15; 95% CI 1.04–1.27), middle (aOR = 1.21; 95% CI 1.09, 1.35), and rich (aOR = 1.18; 95% CI 1.06, 1.31) wealth indexes as compared to poorest, having > 5 family size (AOR = 0.84; 95% CI 0.78, 0.91) primary (aOR = 1.49; 95% CI 1.36, 1.65), and secondary/higher education (aOR = 1.52; 95% CI 1.35, 1.70) as compared to not educated, and married women (aOR = 1.64; 95% CI 1.44, 1.86) have shown a statistically significant association with ITN utilization among pregnant women. …”
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“…In G0, sex-specific associations of adiposity measures and cardiometabolic traits were examined cross-sectionally at 50 y. A total of 3,081 G1 and 4,887 G0 participants contributed to analyses. …”
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“…Spearman analysis was used to investigate the correlation between cluster MDs provided by Octopus perimeter and corresponding sector pRNFLT for the total sample and each subgroup, respectively. Then, linear (y = a+ bx) and curvilinear (quadratic, y = a+bx + cx(2)) regression analyses were employed to investigate the model for the cluster MD-sector pRNFLT pair with significant correlation. …”
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