“…In this study, we found that the silencing of eEF2K enhanced cisplatin (CDDP)-induced cytotoxicity in CDDP-sensitive (HepG2) and resistant (HepG2/CDDP) cells. Calyxin Y, a unique chalcone diarylheptanoid adduct, down-regulated eEF2K by promoting Skp1-Cul1-F-box protein (SCF) β-transducin repeat-containing protein (βTrCP)-mediated protein degradation and synergistically enhanced the cytotoxicity of CDDP. …”
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“…BACKGROUND: Non-coding RNAs play an important role in human carcinogenesis. YRNAs (Ro-associated Y), a novel class of non-coding RNAs, have been identified as biomarker in various malignancies, but remain to be studied in urinary bladder cancer (BCA) patients. …”
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“…These findings demonstrate both the clinical and research utility of the PAGES-Y, a tool that can yield a more nuanced understanding of family-related risk and protective factors in gender-expansive adolescents.…”
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“…To estimate the intensity of each activity, measured oxygen consumption (V˙O(2)) was divided by basal metabolic rate (Schofield age-, sex-, and mass-specific equations) to produce a youth MET (MET(y)). A mixed linear model was developed for each activity category to impute missing values for age ranges with no observations for a specific activity. …”
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“…The resulting molecule was used to chelate (86)Y and (90)Y, a diagnostic and a therapeutic radionuclide, respectively. …”
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“…FUT1 is a key rate-limiting enzyme in the synthesis of Lewis y, a membrane-associated carbohydrate antigen. The aberrant upregulation of FUT1 and Lewis y antigen is related to proliferation, invasion and prognosis in malignant epithelial tumors. …”
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“…In order to test the feasibility of computer simulation in field maize planting, the selection of the method of single seed precise sowing in maize is studied based on the quadratic function model Y = A×(D-Dm)(2)+Ym, which depicts the relationship between maize yield and planting density. …”
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“…RESULTS: The aptamers K3 and K4 showed the highest affinity to N. meningitidis serogroup B and no affinity to N. meningitidis serogroups Y, A, and C, or to other meningitis causing bacteria. …”
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“…Further analysis narrowed down 15 mRNAs potentially processed by RNase Y. A selection of four candidates including folC1 (folylpolyglutamate synthetase), prtF (fibronectin‐binding protein), speG (streptococcal exotoxin G), ropB (transcriptional regulator of speB), and ypaA (riboflavin transporter) mRNAs was examined with Northern blot analysis. …”
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“…Here, we show that the histone-fold domain protein NF-Y, a ubiquitously expressed transcription factor, controls the fidelity of transcription initiation at gene promoters in mouse embryonic stem cells. …”
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“…By employing Candida antarctica lipase B (CALB) as the model enzyme with the Ser-His-Asp catalytic triad, a highly active cysteine-lipase having a Cys-His-Asp catalytic triad and additional mutations W104V/A281Y/A282Y/V149G can be evolved, showing a 40-fold higher catalytic efficiency than wild-type CALB in the hydrolysis of 4-nitrophenyl benzoate, and tolerating bulky substrates. …”
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“…The PPS angle increased on average by 0.233 deg/y. A v-shaped PPS was significantly associated with age (β = 0.087, P = 0.004), peripapillary choroidal thickness (β = −0.479, P < 0.001), lamina cribrosa depth (β = 0.307, P < 0.001), and BM angle (β = 0.487, P < 0.001) after adjusting for best corrected visual acuity, central corneal thickness, and axial length. …”
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“…OPREVENT was implemented in Immediate Intervention community food stores, worksites, schools, and media over 1 y. A community-randomized controlled trial was used to evaluate intervention impact in adults at the individual and institutional levels, with individual-level data being collected on diet, PA, and psychosocial variables at baseline and follow-up; and institutional-level data being collected on food stores, worksites, and schools, media, and process measures. …”
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“…In this study, a comparison of cid and lrg promoter regions with conserved CodY (a regulator which responds to starvation stress)‐binding motifs revealed the presence of a potential CodY‐binding site, which is arranged similarly in both cid and lrg promoters. …”
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“…The most significantly enriched LonA-dependent protein was TfoY, a known regulator of motility and the T6SS in V. cholerae. …”
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“…Immediately after magnetic hyperthermia treatment with Fe(3)O(4):0.1%Y, a decrease in 4T1 cells’ viability was observed (77% for 35 μg/mL and 68% for 100 μg/mL). …”
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“…The expression pattern of blood group A, O(H), Lewis x, y, a, b (Le(x), Le(y), Le(a), and Le(b)), the sialylated and sulfated Le(x) antigens in the uterine LE-conceptus interface was assessed using immunofluorescence assays. …”
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“…By defining a number of points and coordinate axes (X-Y), a criterion for comparing hard and soft tissue changes was obtained. …”
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“…The average age of the patients was 48.8 y. A total of 79.98% of the patients were from Wuhan, Hubei Province. …”
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“…Also, the amino acid residuals at locations 71, 77, 80, 115, 139, 176, and 217 were all the same as A, E, Y, A, A, R, and A, respectively, in the meq gene of the four MDV isolates. …”
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