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281por Ahmad, Bilal, Ashfaq, Usman Ali, Rahman, Mahmood-ur, Masoud, Muhammad Shareef, Yousaf, Muhammad Zubair“…Peptides reported in the present study do not target only Zaire EBOV (ZEBOV), as in previous studies, but also other species, i.e. …”
Publicado 2019
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282por He, Felix B., Khan, Hira, Huttunen, Moona, Kolehmainen, Pekka, Melén, Krister, Maljanen, Sari, Qu, Mengmeng, Jiang, Miao, Kakkola, Laura, Julkunen, Ilkka“…All VP24 proteins were localized both in the cell cytoplasm and nucleus in variable amounts. VP24 proteins of Zaire and Sudan ebolaviruses, Lloviu, Taï Forest, Reston, Marburg and Bundibugyo viruses (EBOV, SUDV, LLOV, TAFV, RESTV, MARV and BDBV, respectively) were found to inhibit both RIG-I and MDA5 stimulated IFN-β and IFN-λ1 promoter activation. …”
Publicado 2022
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283“…Vaccines against the most virulent Ebolavirus species, the Zaire ebolavirus (ZEBOV) are approved. However, there exists no approved vaccine or treatment against the Sudan ebolavirus (SUDV) which causes the current outbreak of EVD. …”
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284por McCarthy, Stephen D. S., Majchrzak-Kita, Beata, Racine, Trina, Kozlowski, Hannah N., Baker, Darren P., Hoenen, Thomas, Kobinger, Gary P., Fish, Eleanor N., Branch, Donald R.“…Using an in vitro model of Ebola Zaire replication with transcription-competent virus like particles (trVLPs), requiring only level 2 biosafety containment, we compared the activities of the type I interferons (IFNs) IFN-α and IFN-ß, a panel of viral polymerase inhibitors (lamivudine (3TC), zidovudine (AZT) tenofovir (TFV), favipiravir (FPV), the active metabolite of brincidofovir, cidofovir (CDF)), and the estrogen receptor modulator, toremifene (TOR), in inhibiting viral replication in dose-response and time course studies. …”
Publicado 2016
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285por Richardson, Eugene T., Kelly, J. Daniel, Barrie, Mohamed Bailor, Mesman, Annelies W., Karku, Sahr, Quiwa, Komba, Marsh, Regan H., Koedoyoma, Songor, Daboh, Fodei, Barron, Kathryn P., Grady, Michael, Tucker, Elizabeth, Dierberg, Kerry L., Rutherford, George W., Barry, Michele, Jones, James Holland, Murray, Megan B., Farmer, Paul E.“…CONCLUSIONS/SIGNIFICANCE: By using ELISA to measure Zaire Ebola virus antibody concentrations, we identified a significant number of individuals with previously undetected EBOV infection in a ‘hotspot’ village in Sierra Leone, approximately one year after the village outbreak. …”
Publicado 2016
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286por Mbanzulu, Kennedy M., Mboera, Leonard E. G., Luzolo, Flory K., Wumba, Roger, Misinzo, Gerald, Kimera, Sharadhuli I.“…METHODS: A search of literature was conducted using Google Scholar, PubMed and the WHO website using the following keywords: “Democratic Republic of the Congo”, “Zaire”, “Belgian Congo” and either of the following: “mosquito-borne virus”, “arbovirus”, “yellow fever”, “dengue”, “chikungunya”, “West Nile”, “Rift Valley fever”, “O’nyong’nyong”, “Zika”, “epidemiology”, “ecology”, “morbidity”, “mortality”. …”
Publicado 2020
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287por Horigan, Verity, Gale, Paul, Kosmider, Rowena D., Minnis, Christopher, Snary, Emma L., Breed, Andrew C., Simons, Robin R.L.“…Two scenarios were considered for Zaire ebolavirus (wEBOV, cEBOV) and other scenarios for Hendra virus, Marburg virus (MARV) and Middle East Respiratory Syndrome Coronavirus (MERS-CoV). …”
Publicado 2017
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288por Figueroa, Dania M., Kuisma, Eeva, Matson, M. Jeremiah, Ondzie, Alain U., Bushmaker, Trent, Seifert, Stephanie N., Ntoumi, Francine, Escudero-Pérez, Beatriz, Muñoz-Fontela, César, Walzer, Chris, Olson, Sarah H., Goma-Nkoua, Cynthia, Mombouli, Jean-Vivien, Fischer, Robert J., Munster, Vincent J.“…The specificity of the assay was confirmed by testing against multiple Zaire Ebolavirus (EBOV) variants and other ebolavirus species. …”
Publicado 2021
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289por Kumar, Jyoti S., Dash, Paban Kumar, Srivastava, Ambuj, Sharma, Shashi, Tandel, Kundan, Parida, Manmohan“…METHODS: A one-step single-tube accelerated quantitative reverse trascription loop-mediated isothermal amplification (RT-LAMP) assay was developed by targeting the NP gene of 2014 Zaire Ebola virus (ZEBOV). The RT-LAMP assay was found to be specific for ZEBOV, without having any cross-reactivity with related haemorrhagic fever viral agents. …”
Publicado 2021
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290por Zhang, Min, Wang, Xinwei, Hu, Linhan, Zhang, Yuting, Zheng, Hang, Wu, Haiyan, Wang, Jing, Luo, Longlong, Xiao, He, Qiao, Chunxia, Li, Xinying, Huang, Weijin, Wang, Youchun, Feng, Jiannan, Chen, Guojiang“…Furthermore, two TIM-1 variants (i.e., TIM-1-359aa and TIM-1-364aa) had comparable effects on promoting Zaire Ebola virus (EBOV) attachment, internalization, and infection. …”
Publicado 2022
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291por Salas-Rojas, Mónica, de Oliveira-Filho, Edmilson Ferreira, Almazán-Marín, Cenia, Rodas-Martínez, Alba Zulema, Aguilar-Setién, Álvaro, Drexler, Jan Felix“…A total of thirty sera of black-handed spider monkeys (Ateles geoffroyi, n = 25), black howler monkeys (Alouatta pigra, n = 3), and mantled howler monkeys (Al. palliata, n = 2) sampled in 2012 and 2018 were screened by an indirect immunofluorescence assay (IFA) to detected IgG antibodies against DENV, YFV, Zika virus (ZIKV), West Nile virus (WNV), Rift Valley fever virus, Crimean-Congo hemorrhagic fever virus, Middle East respiratory syndrome coronavirus, and Zaire Ebola virus, and confirmed by plaque reduction neutralization tests (PRNT(90)) representing all mosquito-borne flavivirus serocomplexes circulating in the Americas. …”
Publicado 2023
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292“…Herein, we performed a large-scale, proteome-wide mapping and diversity analyses of putative HLA supertype-restricted T-cell epitopes of Zaire ebolavirus (ZEBOV), the most pathogenic species among the EBOV family. …”
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293por Ljolje, Dragan, Dimbu, Pedro Rafael, Kelley, Julia, Goldman, Ira, Nace, Douglas, Macaia, Aleixo, Halsey, Eric S., Ringwald, Pascal, Fortes, Filomeno, Udhayakumar, Venkatachalam, Talundzic, Eldin, Lucchi, Naomi W., Plucinski, Mateusz M.“…METHODS: DNA was isolated from pretreatment and late treatment failure dried blood spots collected during the 2015 round of therapeutic efficacy studies in Benguela, Lunda Sul, and Zaire Provinces in Angola. The pfk13 propeller domain and pfmdr1 gene were sequenced and analysed for polymorphisms. …”
Publicado 2018
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294por Geisbert, Thomas W, Lee, Amy CH, Robbins, Marjorie, Geisbert, Joan B, Honko, Anna N, Sood, Vandana, Johnson, Joshua C, de Jong, Susan, Tavakoli, Iran, Judge, Adam, Hensley, Lisa E, MacLachlan, Ian“…BACKGROUND: We previously showed that small interfering RNAs (siRNAs) targeting the Zaire Ebola virus (ZEBOV) RNA polymerase L protein formulated in stable nucleic acid-lipid particles (SNALPs) completely protected guineapigs when administered shortly after a lethal ZEBOV challenge. …”
Publicado 2010
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295por Boum, Yap, Juan-Giner, Aitana, Hitchings, Matt, Soumah, Aboubacar, Strecker, Thomas, Sadjo, Mariama, Cuthbertson, Hannah, Hayes, Peter, Tchaton, Marie, Jemmy, Jean-Paul, Clarck, Carolyn, King, Deborah, Faga, Elisabetta Maria, Becker, Stephan, Halis, Bassam, Gunnstein, Norheim, Carroll, Miles, Røttingen, John-Arne, Kondé, Mandy Kader, Doumbia, Moise, Henao-Restrepo, Ana-Maria, Kieny, Marie-Paule, Cisse, Mohamed, Draguez, Bertrand, Grais, Rebecca F.“…Among samples analysed for cellular response, only 1 (2.2%) exhibited responses towards the Zaire Ebola glycoprotein (Ebola GP ≥ 10) at baseline, 10 (13.5%) at day 28 post-vaccination and 27 (48.2%) at Day 180. …”
Publicado 2020
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296por Bockstal, Viki, Shukarev, Georgi, McLean, Chelsea, Goldstein, Neil, Bart, Stephan, Gaddah, Auguste, Anumenden, Dickson, Stoop, Jeroen N., Marit de Groot, Anne, Pau, Maria G., Hendriks, Jenny, De Rosa, Stephen C., Cohen, Kristen W., McElrath, M. Juliana, Callendret, Benoit, Luhn, Kerstin, Douoguih, Macaya, Robinson, Cynthia“…Of the 30 documented outbreaks of these diseases in sub-Saharan Africa, eight were major outbreaks (≥200 cases; five caused by Zaire ebolavirus [EBOV], two by Sudan ebolavirus [SUDV], and one by Marburg virus [MARV]). …”
Publicado 2022
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297por Zaucha, Gary M, Jahrling, Peter B, Geisbert, Thomas W, Swearengen, James R, Hensley, Lisa“…Cynomolgus monkeys (Macaca fascicularis) were exposed by fine-particle aerosol to lethal doses of monkeypox virus, Zaire strain. Death, attributable to fibrinonecrotic bronchopneumonia, occurred 9 to 17 days postexposure. …”
Publicado 2001
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298por Kulesh, David A, Loveless, Bonnie M, Norwood, David, Garrison, Jeffrey, Whitehouse, Chris A, Hartmann, Chris, Mucker, Eric, Miller, David, Wasieloski, Leonard P, Huggins, John, Huhn, Gregory, Miser, Lori L, Imig, Carroll, Martinez, Mark, Larsen, Tom, Rossi, Cynthia A, Ludwig, George V“…Sequencing the PCR products from the samples indicated 100% identity with monkeypox virus strain Zaire-96-I-16 (a human isolate from the Congo). These real-time PCR and ECL assays represent a significant addition to the battery of tests for the detection of various orthopoxviruses. …”
Publicado 2004
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299por Babirye, Peace, Musubika, Carol, Kirimunda, Samuel, Downing, Robert, Lutwama, Julian J, Mbidde, Edward K, Weyer, Jacqueline, Paweska, Janusz T, Joloba, Moses L, Wayengera, Misaki“…Point-of-care (POC) rapid diagnostic tests (RDTs) are critical for early epidemic detection, reponse and control. There are 2 RDTs for Zaire ebolavirus (EBOV), but not other Ebolavirus spp. or Marburg marburgvirus (MARV). …”
Publicado 2018
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300por Blair, Paul W, Martins, Karen A O, Maryam, Keshtkar-Jahromi, Kortepeter, Mark G, Michael, Keebaugh, Downs, Isaac L, Cardile, Anthony P“…METHODS: This was a post-hoc analysis of an interventional supportive care NHP study in which 13 rhesus macaques were inoculated intramuscularly with a target dose of 1000 PFU Zaire ebolavirus (Kikwit). We measured cytokines with a Luminex MAGPIX panel at baseline and daily starting day 3 post-exposure until euthanasia. …”
Publicado 2019
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