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  1. 6261
    “…Methods: We created a priori hypotheses based on data sources and perceived direct and indirect interactions from koalas vaccinated 6 months prior. …”
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    Capturing Complex Vaccine-Immune-Disease Relationships for Free-Ranging Koalas: Higher Chlamydial Loads Are Associated With Less IL17 Expression and More Chlamydial Disease
  2. 6262
    “…Reliability assessment used internal consistency and inter-rater reliability and construct validity used known-group comparisons and a priori hypotheses on correlations with Brief Symptom Inventory, Short Form-12, and Distress Thermometer. …”
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    Validation of two short versions of the Zarit Burden Interview in the palliative care setting: a questionnaire to assess the burden of informal caregivers
  3. 6263
    “…No clear associations were observed with other a priori relations, including certain behaviors, season, and socioeconomic factors. …”
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    Assessment of Multipollutant Exposures During Pregnancy Using Silicone Wristbands
  4. 6264
    “…We used a phenotypic approach, the streamlined-feedback system control (s-FSC) technique, which does not use a priori information on the mechanism of action of drugs. …”
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    Integrating Phenotypic Search and Phosphoproteomic Profiling of Active Kinases for Optimization of Drug Mixtures for RCC Treatment
  5. 6265
    “…Non-inferiority of the sensitivity of TFE vs neuro-imaging for detecting shunt obstruction was tested using a prospectively determined a priori margin of −2.5%. RESULTS: We enrolled 406 patients at 10 centers. …”
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    Diagnostic Accuracy of Non-Invasive Thermal Evaluation of Ventriculoperitoneal Shunt Flow in Shunt Malfunction: A Prospective, Multi-Site, Operator-Blinded Study
  6. 6266
    “…BACKGROUND: Metagenomic next-generation sequencing (mNGS) has enabled the rapid, unbiased detection and identification of microbes without pathogen-specific reagents, culturing, or a priori knowledge of the microbial landscape. mNGS data analysis requires a series of computationally intensive processing steps to accurately determine the microbial composition of a sample. …”
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    IDseq—An open source cloud-based pipeline and analysis service for metagenomic pathogen detection and monitoring
  7. 6267
    “…Our results advocate that it is problematic to exclude frail older people a priori and that there is a potential for new perspectives and knowledge to be shaped in the encounter and in the relationship between the researcher and the frail older person. …”
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    Challenging oneself on the threshold to the world of research – frail older people’s experiences of involvement in research
  8. 6268
    “…Group comparisons and predictive models will test the a priori hypotheses that, compared with children from the community or with orthopaedic injuries, children with mTBI will (1) display more postconcussive symptoms and exhibit poorer motor, cognitive, social and behavioural functioning; (2) show evidence of altered brain structure and function, poorer sleep and higher levels of stress hormones. …”
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    Kids’ Outcomes And Long-term Abilities (KOALA): protocol for a prospective, longitudinal cohort study of mild traumatic brain injury in children 6 months to 6 years of age
  9. 6269
    “…Regression modeling was used to investigate the relationships among a priori selected perioperative variables, complications, and costs. …”
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    Postoperative complications and hospital costs following small bowel resection surgery
  10. 6270
    “…The research question and eligibility criteria were established a priori. Any clinical outcome study that described factors relating to overall satisfaction after primary TKR was included. …”
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    Why are patients dissatisfied following a total knee replacement? A systematic review
  11. 6271
    “…RESULTS: The PFActS-C-DLV showed good to excellent internal consistency (Cronbach’s alpha: 0.98) and stability over time (ICC: 0.90 [95%CI: 0.82–0.93). Four out of five a priori formulated hypotheses regarding related (convergent validity) and unrelated (discriminant validity) constructs were confirmed. …”
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    Cross-cultural adaptation and validation of the Dutch language version of the Pictorial Fear of Activity Scale – Cervical
  12. 6272
    “…Annualized ASCVD event rates were used to extrapolate 5-year ASCVD risk for each treatment group reported in subgroup analyses, which were grouped into a priori risk groups according to annualized placebo/control rates of ≥4%, 3–3.9%, or <3% ASCVD risk. …”
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    Clinical implications of the log linear association between LDL-C lowering and cardiovascular risk reduction: Greatest benefits when LDL-C >100 mg/dl
  13. 6273
    “…Descriptive analyses were conducted for the total survey sample and for subgroups defined a priori by experience with specific, prevalent side effects. …”
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    Antipsychotic Treatment Experiences of People with Schizophrenia: Patient Perspectives from an Online Survey
  14. 6274
    “…Regional differences in [(11)C]CURB binding were assessed using multivariate analysis of covariance with PFC and amygdala [(11)C]CURB binding as dependent variables, diagnosis as a fixed factor, and sex and genotype as covariates. [(11)C]CURB binding was marginally elevated across the PFC and amygdala in BPD (p = 0.08). In a priori selected PFC, but not amygdala, [(11)C]CURB binding was significantly higher in BPD (11.0%, p = 0.035 versus 10.6%, p = 0.29). …”
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    Elevated fatty acid amide hydrolase in the prefrontal cortex of borderline personality disorder: a [(11)C]CURB positron emission tomography study
  15. 6275
    “…METHODS: We identified and internally validated the association between 20 a-priori selected plasma inflammatory markers and unfavorable treatment outcomes of failure, recurrence and all-cause mortality among adults with drug-sensitive pulmonary tuberculosis in India. …”
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    Baseline IL-6 is a biomarker for unfavorable tuberculosis treatment outcomes: a multi-site discovery and validation study
  16. 6276
    “…MAIN OUTCOME MEASURES: The main outcome was consensus agreement, defined a priori as ≥70% of participants with a mean Likert score ≥7.0 (11-point scale: 0=strongly disagree, 10=strongly agree). …”
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    A Consensus Statement for the Management and Rehabilitation of Communication and Swallowing Function in the ICU: A Global Response to COVID-19
  17. 6277
    “…CONCLUSION: As hypothesized a priori, the findings of the current affirmed multiple dimensions of how sociological obesogenic factors may influence children’s BMI status changes in a longitudinal setting. …”
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    Longitudinal analysis of Socioecological obesogenic factors in a National Sample of U.S. children
  18. 6278
    “…Interview probes addressed the 78 PRO-CTCAE symptom terms (e.g. fatigue), as well as the attributes (e.g. severity), response choices, and phrasing of ‘at its worst’. Items that met the a priori threshold of ≥20% of participants with comprehension difficulties were considered for rephrasing and retesting. …”
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    Linguistic validation of the simplified Chinese version of the US National Cancer Institute’s patient-reported outcomes version of the common terminology criteria for adverse events (PRO-CTCAE™)
  19. 6279
    “…Therefore, we did not calculate an a priori sample size regarding sex differences. We conducted the study at 4 day-surgery settings in Sweden from October 2015 to July 2016. …”
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    Sex Similarities in Postoperative Recovery and Health Care Contacts Within 14 Days With mHealth Follow-Up: Secondary Analysis of a Randomized Controlled Trial
  20. 6280
    “…Only three studies used a limits of agreement (LOA) criterion that specified a priori an acceptable difference between novel and validated values in absolute units. …”
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    A Critical Review of Ultra-Short-Term Heart Rate Variability Norms Research
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