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  1. 6581
    “…Data were analysed using framework analysis to identify a priori and emergent themes. RESULTS: High uptake (around 70 placements per annum), low dropout (2–3 students per annum; 5 %) and positive focus group comments suggested placements successfully provided added value and catered sufficiently to student demand. …”
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    Post graduate clinical placements: evaluating benefits and challenges with a mixed methods cross sectional design
  2. 6582
    “…In order to isolate the effects of duration of illness alone, cytokines that changed significantly with age in the healthy control subjects were excluded a priori. RESULTS: Optimal selection of cytokines in each group resulted in subsets of IL-1α, 6, 8, 15 and TNFα. …”
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    Illness progression in chronic fatigue syndrome: a shifting immune baseline
  3. 6583
    “…The cat AIPL1 variant would have been considered a high priority variant for evaluation, regardless of a priori knowledge from previous genetic studies. CONCLUSIONS: This study represents the first effort of the 99 Lives Cat Genome Sequencing Initiative to identify disease - causing variants in the domestic cat using WGS. …”
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    Whole genome sequencing in cats, identifies new models for blindness in AIPL1 and somite segmentation in HES7
  4. 6584
    “…Dorsal gland promoter element-containing effectors are at the front line of the evolutionary arms race between plant and parasite and the ability to predict gland cell expression a priori promises rapid advances in understanding their roles and mechanisms of action. …”
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    The genome of the yellow potato cyst nematode, Globodera rostochiensis, reveals insights into the basis of parasitism and virulence
  5. 6585
    “…Spearman correlation was also used to assess the relationship between FMS, number of asymmetries, number of games missed and number of injuries recorded. The a priori alpha level was established at p ≤.05 RESULTS: Overall 1228 (97.2%) of participants reported one or more injuries. …”
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    Functional Movement Screen and Prior Injury in National Football League Combine Athletes
  6. 6586
    “…Main outcome measures Effectiveness outcomes defined a priori were ischaemic stroke; a composite of ischaemic stroke or systemic embolism; death; and a composite of ischaemic stroke, systemic embolism, or death. …”
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    Comparative effectiveness and safety of non-vitamin K antagonist oral anticoagulants and warfarin in patients with atrial fibrillation: propensity weighted nationwide cohort study
  7. 6587
    “…We uncovered both shared and unique patterns of evolution: most extremophile Gambusia predictably evolved larger heads and offspring size, matching a priori predictions for adaptation to sulfidic waters, while variation in adult life histories was idiosyncratic. …”
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    Extremophile Poeciliidae: multivariate insights into the complexity of speciation along replicated ecological gradients
  8. 6588
    “…Intent to treat analyses will test two a priori hypotheses: (1) MFG-SCI will be superior to SCIEC for SCI patient activation, health status, and emotion regulation, caregiver burden and health status, and relationship functioning, and (2) MFG will be more effective for individuals with SCI and their caregivers when the person with SCI is within 18 months of discharge from inpatient rehabilitation compared to when the person is between 19 and 36 months post discharge. …”
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    Comparison of two psycho-educational family group interventions for improving psycho-social outcomes in persons with spinal cord injury and their caregivers: a randomized-controlled trial of multi-family group intervention versus an active education control condition
  9. 6589
    “…However, the majority of current CTC capture methods rely on positive selection techniques that require a priori knowledge about the surface protein expression of disseminated CTCs, which are known to be a dynamic population. …”
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    Nanoroughened adhesion-based capture of circulating tumor cells with heterogeneous expression and metastatic characteristics
  10. 6590
    “…PRIMARY AND SECONDARY OUTCOME MEASURES: The primary outcome measure was change in mean daily dose of oral corticosteroids (OCS) between the 12-month pre-omalizumab and post-omalizumab initiation periods. A priori secondary outcome measures included response to treatment, changes in OCS dosing, asthma exacerbations, lung function, employment/education, patient-reported outcomes and hospital resource utilisation. …”
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    Impact of omalizumab on treatment of severe allergic asthma in UK clinical practice: a UK multicentre observational study (the APEX II study)
  11. 6591
    “…METHODS: Thin strut cobalt chromium BMS implantation in a priori pre-defined subgroups was investigated in a non-randomized, international, multi-center ‘all-comers’ observational study. …”
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    The outcomes of patients with very small coronary artery disease treated with thin strut cobalt chromium bare metal stents: an observational study
  12. 6592
    “…This included availability of trained scientific personnel for local project management, data collection and analysis by medical personnel, entomologists and demographers and teams of fieldworkers for the larviciding intervention. A detailed a priori assessment of the environment and vector breeding site ecology was essential to calculate personnel requirements and the need for larvicide and application apparel. …”
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    Challenges of implementing a large scale larviciding campaign against malaria in rural Burkina Faso – lessons learned and recommendations derived from the EMIRA project
  13. 6593
    “…To control for the effect of age, weight, duration of symptoms, and years of experience, the variables were included as covariates. An a priori level was set at P < .05. RESULTS: There was a statistically significant relationship between the GIRD, ERDiff, and TRM results compared with HTDiff (P = .003). …”
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    The Relationship Between Humeral Retrotorsion and Shoulder Range of Motion in Baseball Players With an Ulnar Collateral Ligament Tear
  14. 6594
    “…Known groups’ validity was examined by comparing groups with a priori expected differences in health-related quality of life (HRQOL). …”
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    Reliability and validity of the EQ-5D-3L for Kashin–Beck disease in China
  15. 6595
    “…Using multivariable logistic regression, we analyzed whether age, delirium duration, atypical antipsychotic use, and discharge disposition (each selected a priori) were independent risk factors for discharge on an antipsychotic. …”
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    Antipsychotic prescribing patterns during and after critical illness: a prospective cohort study
  16. 6596
    “…MRAs were associated with a reduced risk of cardiovascular death (RR 0.81 [0.75–0.87], I(2) 0%), all-cause mortality (RR 0.83 [0.77–0.88], I(2) 0%), and cardiac hospitalizations (RR 0.80 [0.70–0.92], I(2) 58.4%). However, an a-priori specified subgroup analysis demonstrated that these benefits were limited to HFrEF (cardiovascular death RR 0.79 [0.73–0.86], I(2) 0%; all-cause mortality RR 0.81 [0.75–0.87], I(2) 0%; cardiac hospitalizations RR 0.76 [0.64–0.90], I(2) 68%), but not HFpEF (all-cause mortality RR 0.92 [0.79–1.08], I(2) 0%; cardiac hospitalizations RR 0.91 [0.67–1.24], I(2) 17%). …”
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    Mineralocorticoid receptor antagonists for heart failure: systematic review and meta-analysis
  17. 6597
    “…As the best SP for a target protein of choice cannot be predicted a priori, screening of homologous SPs has been shown to be a powerful tool for different expression organisms. …”
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    Use of a Sec signal peptide library from Bacillus subtilis for the optimization of cutinase secretion in Corynebacterium glutamicum
  18. 6598
    “…The study is designed as adaptive a priori: the patients from this study can be included in a later phase IIb study. …”
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    Abdominal Septic Shock – Endotoxin Adsorption Treatment (ASSET) – endotoxin removal in abdominal and urogenital septic shock with the Alteco® LPS Adsorber: study protocol for a double-blinded, randomized placebo-controlled trial
  19. 6599
    “…Analyses from this study will focus on generating point estimates and corresponding 95 % confidence intervals for parameters of a priori interest (recruitment, retention, adherence, pain intensity, Neck Disability Index). …”
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    Testing the feasibility of a knowledge translation intervention designed to improve chiropractic care for adults with neck pain disorders: study protocol for a pilot cluster-randomized controlled trial
  20. 6600
    “…The plausibility of the fMRI-ROI- vs. nTMS-ROI-based fibre trajectories was assessed by a-priori defined anatomical criteria. Moreover, the anatomical relationship of different fibre courses was compared regarding their distribution in the anterior-posterior direction as well as their location within the posterior limb of the internal capsule (PLIC). …”
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    Functional MRI vs. navigated TMS to optimize M1 seed volume delineation for DTI tractography. A prospective study in patients with brain tumours adjacent to the corticospinal tract
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