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  1. 6641
    “…Analysis of post-exercise intervention transcripts identified four main themes within a priori themes of barriers and facilitators to program adherence (median of 46.9%; 5.4, 66.7 IQR): 1) parental support, 2) enjoyment, 3) time pressures (subthemes: time requirement of exercise, scheduling, forgetting) and 4) physical ailments. …”
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    “I just want to get better”: experiences of children and youth with juvenile idiopathic arthritis in a home-based exercise intervention
  2. 6642
    “…RESULTS: Of the patients with detectable DTCs by DIF, 27% had ≥ 50% NR2F1(high) DTCs, chosen a priori as the cut-off for “dormant profile” classification. …”
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    NR2F1 stratifies dormant disseminated tumor cells in breast cancer patients
  3. 6643
    “…All analyses were performed using random effects models and heterogeneity was quantified. We a priori specified changes in biomarkers of hemoglobin A1c (in percentage) and fasting blood glucose (mmol/L) as the main outcomes and triglycerides, total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein-cholesterol, 2-h plasma glucose, and fasting plasma glucose as secondary outcomes. …”
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    Association of traditional Chinese exercises with glycemic responses in people with type 2 diabetes: A systematic review and meta-analysis of randomized controlled trials
  4. 6644
    “…This pre-specified statistical analysis plan was written and submitted without knowledge of the study data. DISCUSSION: This a priori statistical analysis plan aims to enhance the transparency of our study, facilitating unbiased analyses of ICU visit study data, and provide guidance for statistical analysis for groups conducting studies in the same field. …”
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    Statistical analysis plan for a cluster-randomized crossover trial comparing the effectiveness and safety of a flexible family visitation model for delirium prevention in adult intensive care units (the ICU Visits Study)
  5. 6645
    “…All currently existing classification methods have in common that a priori assumptions about the characteristics of certain stand structural attributes such as deadwood amount are made. …”
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    Classifying development stages of primeval European beech forests: is clustering a useful tool?
  6. 6646
    “…Two reviewers independently screened comparative studies (randomized or non-randomized controlled trials, and observational designs) according to a priori eligibility criteria: women with prior cesarean sections; any adjunct clinical intervention or exposure intended to increase the VBAC rate; any comparator; and, outcomes reporting changes in TOLAC or VBAC rates. …”
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    Adjunct clinical interventions that influence vaginal birth after cesarean rates: systematic review
  7. 6647
    “…The plan is composed in accordance with the recipient’s a priori risk as to CMV IgG serostatus and is continually updated during the post-transplant course according to patient′s current situation. …”
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    1579. Evaluation of MATCH: an Electronic Individual Patient-Focused Management System Aimed at Preventing Cytomegalovirus Disease Following Solid Organ Transplantation
  8. 6648
    “…We included variables significantly associated at the univariate level (P < 0.10), and those determined of importance a priori, in a multivariable logistic regression. RESULTS: We enrolled a total of 261 participants; 136 in India, 125 in South Africa. …”
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    428. Mobile Phone Access and Comfort: Implications for HIV and Tuberculosis Care in India and South Africa
  9. 6649
    “…Potential correlates of change were specified a priori. We used unadjusted and adjusted sex-stratified linear regressions to identify correlates of change. …”
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    Descriptive epidemiology of changes in objectively measured sedentary behaviour and physical activity: six-year follow-up of the EPIC-Norfolk cohort
  10. 6650
    “…Quality scores of the apps with and without 17 a priori selected characteristics were compared using independent sample t tests. …”
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    Mobile Apps for Blood Pressure Monitoring: Systematic Search in App Stores and Content Analysis
  11. 6651
    “…Secondary outcomes will be analyzed using the same modeling approach as for the primary outcome, with appropriate distributions within the exponential family and corresponding link functions. DISCUSSION: The a priori statistical analysis plan will avoid reporting bias and data-driven analysis for the primary and key secondary outcomes. …”
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    Statistical analysis plan for the control of blood pressure and risk attenuation-rural Bangladesh, Pakistan, Sri Lanka (COBRA-BPS) trial: a cluster randomized trial for a multicomponent intervention versus usual care in hypertensive patients
  12. 6652
    “…Among the entire cohort, 47% (14/30) experienced diaphragm atrophy (defined a priori as ≥10% decrease in thickness). Eighty three percent of patients (25/30) experienced atrophy in ≥1 muscle group, and 47% (14/30)—in ≥2 muscle groups. …”
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    Muscle atrophy in mechanically-ventilated critically ill children
  13. 6653
    “…Statistical significance was determined a priori at p < 0.05. RESULTS: One hundred forty eight medical students (57% female) responded with 78 students in the spiral curriculum and 70 students the block curriculum. …”
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    Cross-sectional comparison of spiral versus block integrated curriculums in preparing medical students to diagnose and manage concussions
  14. 6654
    “…Thematic content analysis of transcribed interviews identified both a priori and emergent themes. Results: Eleven index patients and their adolescents participated in in-depth interviews. …”
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    Understanding Family-Level Effects of Adult Chronic Disease Management Programs: Perceived Influences of Behavior Change on Adolescent Family Members' Health Behaviors Among Low-Income African Americans With Uncontrolled Hypertensions
  15. 6655
    “…The Mixed Methods Appraisal Tool (MMAT) was used for quality appraisal and an a priori data collection instrument was used. For the quantitative studies, a narrative synthesis approach was taken. …”
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    Deprescribing interventions and their impact on medication adherence in community-dwelling older adults with polypharmacy: a systematic review
  16. 6656
    “…Behavioural predictors were established a priori and tested in a multivariable model. RESULTS: Primary outcome: Providers assessed asthma control in 4.9% of visits and 15.4% of patients. …”
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    Large care gaps in primary care management of asthma: a longitudinal practice audit
  17. 6657
    “…Using a mixed linear regression model, changes in reciprocal transformed PVT reaction time (mean 1/RT) were assessed. A priori, an increase in median PVT reaction times by > 20 ms (approximating PVT changes with blood alcohol concentrations of 0.04–0.05 g%) was considered clinically relevant. …”
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    Immediate-term cognitive impairment following intravenous (IV) chemotherapy: a prospective pre-post design study
  18. 6658
    “…In this paper we describe our experience and rates of recruitment and retention of underrepresented groups for the Aides in Respiration (AIR) COPD Health Coaching Study. METHODS: A priori design strategies included minimizing exclusion criteria, including patients in the study process, establishing partnerships with the community clinics, and ensuring that the health coaching intervention was flexible enough to accommodate patient needs. …”
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    Strategies for recruitment and retention of underrepresented populations with chronic obstructive pulmonary disease for a clinical trial
  19. 6659
    “…BACKGROUND: An a priori design is essential to reduce the risk of bias in systematic reviews (SRs). …”
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    A descriptive analysis of the characteristics and the peer review process of systematic review protocols published in an open peer review journal from 2012 to 2017
  20. 6660
    “…Daytime sleepiness (Karolinska Sleepiness Scale) was a priori identified as the most important secondary outcome. …”
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    Positive airway pressure for sleep-disordered breathing in acute quadriplegia: a randomised controlled trial
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