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  1. 74481
    “…BACKGROUND: Receptive and expressive vocabulary in adult and adolescent males with fragile X syndrome (FXS) have been shown as significantly lower than their chronological age; however, receptive vocabulary has been considered a strength relative to mental age. …”
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    Vocabulary comprehension in adults with fragile X syndrome (FXS)
  2. 74482
    “…Model-based simulations suggested that a tapentadol OS dose of 1.25 mg/kg to children and adolescents aged 2 to <18 years would result in efficacious tapentadol exposures similar to those in adults receiving tapentadol immediate release 50–100 mg every 4 hrs. …”
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    Population pharmacokinetic modeling to facilitate dose selection of tapentadol in the pediatric population
  3. 74483
    por Wilder-Smith, Annelies, Preet, Raman, Brickley, Elizabeth B., Ximenes, Ricardo Arraes de Alencar, Miranda-Filho, Demócrito de Barros, Turchi Martelli, Celina Maria, de Araújo, Thália Velho Barreto, Montarroyos, Ulisses Ramos, Moreira, Maria Elisabeth, Turchi, Marília Dalva, Solomon, Tom, Jacobs, Bart C., Villamizar, Carlos Pardo, Osorio, Lyda, de Filipps, Ana Maria Bispo, Neyts, Johan, Kaptein, Suzanne, Huits, Ralph, Ariën, Kevin K., Willison, Hugh J., Edgar, Julia M., Barnett, Susan C., Peeling, Rosanna, Boeras, Debi, Guzman, Maria G., de Silva, Aravinda M., Falconar, Andrew K., Romero-Vivas, Claudia, Gaunt, Michael W., Sette, Alessandro, Weiskopf, Daniela, Lambrechts, Louis, Dolk, Helen, Morris, Joan K., Orioli, Ieda M., O’Reilly, Kathleen M., Yakob, Laith, Rocklöv, Joacim, Soares, Cristiane, Ferreira, Maria Lúcia Brito, Franca, Rafael Freitas de Oliveira, Precioso, Alexander R., Logan, James, Lang, Trudie, Jamieson, Nina, Massad, Eduardo
    Publicado 2019
    “…Here we present a report on ZikaPLAN`s mid-term achievements since its initiation in October 2016 to June 2019, illustrating the research objectives of the 15 work packages ranging from virology, diagnostics, entomology and vector control, modelling to clinical cohort studies in pregnant women and neonates, as well as studies on the neurological complications of Zika infections in adolescents and adults. For example, the Neuroviruses Emerging in the Americas Study (NEAS) has set up more than 10 clinical sites in Colombia. …”
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    ZikaPLAN: addressing the knowledge gaps and working towards a research preparedness network in the Americas
  4. 74484
    “…BACKGROUND: Osteosarcoma is one of the most common primary bone cancers with predominant occurrence in children and adolescents. This study aimed to determine the effects of sevoflurane treatment on the osteosarcoma progression and to explore the underlying molecular mechanisms. …”
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    Sevoflurane Inhibited Osteosarcoma Cell Proliferation And Invasion Via Targeting miR-203/WNT2B/Wnt/β-Catenin Axis
  5. 74485
    “…BACKGROUND: The one-month prevalence of back pain in children and adolescents has been reported at 33, 28 and 48% at ages 9, 13 and 15 respectively. …”
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    Potential risk factors and triggers for back pain in children and young adults. A scoping review, part I: incident and episodic back pain
  6. 74486
    “…We aim to compare effectiveness of a patient navigator service in reducing emergency room (ER) use among adolescents with chronic health conditions transitioning to adult care. …”
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    Pragmatic trial evaluating the effectiveness of a patient navigator to decrease emergency room utilisation in transition age youth with chronic conditions: the Transition Navigator Trial protocol
  7. 74487
    “…Osteosarcoma (OS) is the most common primary bone tumor that primarily affects children and adolescents. Studies suggested that dysregulation JAK/STAT signaling promotes the development of OS. …”
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    Suppressing STAT5 signaling affects osteosarcoma growth and stemness
  8. 74488
    “…Nine studies included male survivors, twelve studies focussed exclusively on female survivors and one study targeted children and adolescents. No intervention evaluation focussed on LGBT survivors of CRSV. …”
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    Male and LGBT survivors of sexual violence in conflict situations: a realist review of health interventions in low-and middle-income countries
  9. 74489
    “…METHODS: An open-label, controlled, non-randomized, real-life study was conducted to evaluate the effectiveness of NI with a new hypertonic solution as add-on treatment for AR. Children and adolescents with AR were prescribed symptomatic treatment. …”
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    Effect of nasal irrigation on allergic rhinitis control in children; complementarity between CARAT and MASK outcomes
  10. 74490
    “…AIM: This study investigates on parenting stress in children and adolescents with CF and its determinants related to parents, children and the disease severity. …”
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    An investigation on parenting stress of children with cystic fibrosis
  11. 74491
    por Dudley, Joseph P., Mackay, Ian M.
    Publicado 2013
    “…Human A(H7N9) cases exhibit high degrees of age and sex bias: mortality is heavily biased toward males >50 years, no deaths have been reported among individuals <25 years old, and relatively few cases documented among children or adolescents. The proportion of fatal cases (PFC) for human A(H7N9) cases as of 11 August 2013 was 32%, compared to a cumulative PFC for A(H5N1) of 83% in Indonesia and 36% in Egypt. …”
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    Age-specific and sex-specific morbidity and mortality from avian influenza A(H7N9)
  12. 74492
    “…The aim of the present cross-sectional study was to investigate whether children and adolescents with OI and oligodontia and hypodontia also present with variants in other genes with potential effects on tooth development. …”
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    Mutations in COL1A1/A2 and CREB3L1 are associated with oligodontia in osteogenesis imperfecta
  13. 74493
    “…On the contrary, cell lines from patients with juvenile and adolescent/adult phenotypes showed values comparable to controls. …”
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    Transcript, protein, metabolite and cellular studies in skin fibroblasts demonstrate variable pathogenic impacts of NPC1 mutations
  14. 74494
    “…METHODS: We performed a single-center retrospective cohort study of children and adolescents (<18 years of age) who underwent HSCT over a 20-year period (1997–2016). …”
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    Microbiology and Risk Factors for Hospital-Associated Bloodstream Infections Among Pediatric Hematopoietic Stem Cell Transplant Recipients
  15. 74495
    “…This review aims to (1) identify all available instruments measuring breakthrough pain in infants, children, adolescents or adults and (2) critically appraise, compare and summarise the quality of the psychometric properties of the identified instruments using COnsensus-based Standards for the selection of health Measurement INstruments (COSMIN) criteria. …”
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    A protocol for a systematic review and meta-analysis to identify measures of breakthrough pain and evaluate their psychometric properties
  16. 74496
    “…The end-product, which launched 26 March 2018, includes an overview of severe asthma, diagnosis and assessment, management, medications, comorbidities, living with severe asthma, establishing a clinic, paediatrics/adolescents and clinical resources. Analytics indicate access by users worldwide (32 169 users from 169 countries). …”
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    Severe Asthma Toolkit: an online resource for multidisciplinary health professionals—needs assessment, development process and user analytics with survey feedback
  17. 74497
    “…Clinical diagnosis of FH in adults is based on elevated LDLc levels ≥ 4,9 mmol/L and total cholesterol (TC) ≥ 7,5 mmol/L; in untreated children and adolescents LDLc ≥ 4,0 mmol/L and TC ≥ 6,7 mmol/L, associated or not with physical signs (xanthomas, corneal arch). …”
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    SUN-561 Genetic Variants Related to Familial Hypercholesterolemia in Clusters from Minas Gerais - a Southeast State of Brazil
  18. 74498
    “…OBJECTIVES: To present the results of a systematic diagnostic workup in children and adolescents referred to a specialized pediatric obesity center. …”
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    Identifying underlying medical causes of pediatric obesity: Results of a systematic diagnostic approach in a pediatric obesity center
  19. 74499
    “…Burosumab has also received conditional marketing authorization in Europe to treat XLH with radiographic evidence of bone disease in children ≥1 year of age and in adolescents with growing skeletons. Burosumab significantly improved serum phosphorus, fracture/pseudofracture healing, stiffness, and physical functioning in a phase 3, double-blind, multicenter study (CL303, NCT02526160). …”
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    OR29-01 Long-Term Safety in Adults with X-Linked Hypophosphatemia (XLH) Treated with Burosumab, a Fully Human Monoclonal Antibody Against FGF23: Final Results of a Phase 3 Trial
  20. 74500
    “…Validated and published quantitative measures, semi-structured interviews, and a review of electronic health record data conducted over a 12-month period following disclosure of results will allow for comparison of psychosocial and behavioral outcomes among parents of minors (ages 0–17) and adolescents (ages 11–17) in each group. DISCUSSION: These data will provide guidance about the risks and benefits of informing minors and their family members about clinically actionable, adult-onset genetic conditions and, in turn, help to ensure these patients receive care that promotes physical and psychosocial health. …”
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    Pediatric reporting of genomic results study (PROGRESS): a mixed-methods, longitudinal, observational cohort study protocol to explore disclosure of actionable adult- and pediatric-onset genomic variants to minors and their parents
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