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20781por Atencia-Flórez, Carlos, Quintero-Valencia, Catalina, Mondragón-Arismendy, María, Cardona-Arias, Andrés, Regino-Agamez, Carlos, Vélez-Urrego, Julián“…The diagnosis of multiple myeloma was documented at younger ages, with more advanced stages, anemia, and a high percentage of bone disease. ISS provides an excellent tool for prognosis purposes. …”
Publicado 2023
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20782por Del Fabro, Vittorio, Di Giorgio, Mary Ann, Leotta, Valerio, Duminuco, Andrea, Bellofiore, Claudia, Markovic, Uros, Romano, Alessandra, Bulla, Anna, Curto Pelle, Angelo, Elia, Federica, Di Raimondo, Francesco, Conticello, Concetta“…In univariate analysis, high ISS, high serum β2-microglobulin, and creatinine clearance <30 mL/min negatively impact OS, while the depth of response positively impacts OS. Moreover, G3-4 anemia, ISS, frailty score, and ECOG negatively impacts PFS. …”
Publicado 2023
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20783por Rizq, Ola, Mimura, Naoya, Oshima, Motohiko, Momose, Shuji, Takayama, Naoya, Itokawa, Naoki, Koide, Shuhei, Shibamiya, Asuka, Miyamoto-Nagai, Yurie, Rizk, Mohamed, Nakajima-Takagi, Yaeko, Aoyama, Kazumasa, Wang, Changshan, Saraya, Atsunori, Ito, Ryoji, Seimiya, Masanori, Watanabe, Mariko, Yamasaki, Satoshi, Shibata, Tatsuhiro, Yamaguchi, Kiyoshi, Furukawa, Yoichi, Chiba, Tetsuhiro, Sakaida, Emiko, Nakaseko, Chiaki, Tamaru, Jun-ichi, Tai, Yu-Tzu, Anderson, Kenneth C., Honda, Hiroaki, Iwama, Atsushi“…Mice that developed MM-like neoplasms showed expansion of clonal plasma cells in the bone marrow and extramedullary organs, serum M proteins, and anemia. Add-back of either wild-type UTX or a series of mutants revealed that cIDR domain, that forms phase-separated liquid condensates, is largely responsible for the catalytic activity-independent tumor suppressor function of UTX in MM cells. …”
Publicado 2023
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20784por Satahoo, Shevonne S, Okeke, Barbara, Kaufman, Joyce I, Nabeta, Geraldine, Pizano, Louis R, Schulman, Carl I“…The presence of AIDS, chronic blood loss anemia, chronic pulmonary disease, congestive heart failure, peptic ulcer disease (excluding bleeding), peripheral vascular disease, renal failure, rheumatoid arthritis/collagen vascular disease, and solid tumor without metastasis were not found to be statistically significant. …”
Publicado 2023
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20785“…In our study, hemorrhage and hypertensive disorder in pregnancy were the leading cause of morbidity and mortality followed by sepsis and severe anemia. Among organ dysfunction cardiac illness followed by respiratory dysfunction was the leading cause of morbidity and mortality. …”
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20786por Schöffski, Patrick, Bahleda, Rastislav, Wagner, Andrew J., Burgess, Melissa A., Junker, Niels, Chisamore, Michael, Peterson, Patrick, Szpurka, Anna M., Ceccarelli, Matteo, Tap, William D.“…No dose-limiting toxicities and few grade ≥ 3 treatment-emergent adverse events [TEAE; 15 mg/kg: 2 (increased lipase); 20 mg/kg: 1 (increased lipase), 1 (colitis), 2 (diarrhea), 3 (anemia)] were reported. Two TEAEs (increased lipase) were related to study discontinuations. …”
Publicado 2023
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20787por Sapkota, Prakash, Mainali, Sumina, Khadayat, Paras, K.C., Narendra, Joshi, Arun, Koirala, Prashant“…The patient was also advised for splenectomy for splenomegaly and ongoing anemia and thrombocytopenia. CONCLUSION: The main aim of the article is to highlight a rare case of protein S deficiency that has led to upper GI bleeding due to esophageal varices secondary to portal hypertension secondary to PVT. …”
Publicado 2023
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20788por Sayaf, Abrar Mohammad, Ullah Khalid, Saif, Hameed, Jawad Ahmed, Alshammari, Abdulrahman, Khan, Abbas, Mohammad, Anwar, Alghamdi, Saeed, Wei, Dong-Qing, Yeoh, KarKheng“…Introduction: Hypoxia-inducible factor (HIF) prolyl hydroxylase domain (PHD) enzymes are major therapeutic targets of anemia and ischemic/hypoxia diseases. To overcome safety issues, liver failure, and problems associated with on-/off-targets, natural products due to their novel and unique structures offer promising alternatives as drug targets. …”
Publicado 2023
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20789por Geng, Hongzhi, Jia, Sixun, Zhang, Ying, Li, Jiaqi, Yang, Qin, Zeng, Liangyu, Zong, Xiangping, Lu, Yutong, Lu, Shuangzhu, Zhou, Jin, Li, Caixia, Wu, Depei“…Hematological adverse events (AEs) ≥ grade 3 included neutropenia (50%), thrombocytopenia (23.1%), and anemia (7.7%) whereas non-hematological AEs ≥ grade 3 included pulmonary infection (19.2%). …”
Publicado 2023
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20790por Ponce, Santiago, Cedrés, Susana, Ricordel, Charles, Isambert, Nicolas, Viteri, Santiago, Herrera-Juarez, Mercedes, Martinez-Marti, Alex, Navarro, Alejandro, Lederlin, Mathieu, Serres, Xavier, Zugazagoitia, Jon, Vetrhus, Sylvia, Jaderberg, Magnus, Hansen, Thomas Birkballe, Levitsky, Victor, Paz-Ares, Luis“…RESULTS: In total, 31 patients (safety lead-in: n=6, randomized: n=25) were enrolled. Anemia (15.0% and 27.3%) and neutropenia (40.0% and 45.5%) were the most frequent grade ≥3 adverse events (AEs) in the ONCOS-102 (n=20) and chemotherapy-alone (n=11) cohorts. …”
Publicado 2023
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20791“…The most frequently represented transplant indication for releases was hemoglobinopathies including sickle cell anemia and beta thalassemia (44.6%). Approximately one-third (36.1%) of transplant releases were related to leukemia. …”
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20792por Balulescu, Ligia, Nistor, Samuel, Lungeanu, Diana, Brasoveanu, Simona, Pirtea, Marilena, Secosan, Cristina, Grigoras, Dorin, Caprariu, Radu, Pasquini, Andrea, Pirtea, Laurentiu“…There was a statistically significant higher need for postoperative iron perfusion in the “LM” group, specifically 0 vs. 12 patients (p < 0.001), and lower postoperative anemia in “LM + TOHA” group (p < 0.001). Necessary artery clipping time was 10.62 ± 2.47 (7–15) minutes, with no significant impact on overall operative time: 110.2 ± 13.65 vs. 106.3 ± 16.48 (p = 0.21). …”
Publicado 2023
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20793por Khan, Behram A, Tagore, Rajat, Rastogi, Shilpa, Hua, Yan, See, Vincent W, Qu, XiaoJie, Wee, Hwee Lin, Cai, Celestine Grace X“…Results: There was no statistically significant difference in hospitalization and mortality outcomes, adherence to dialysis management, laboratory results for dialysis-related clearance, and anemia outcomes. There was a higher proportion of patients hospitalized for vascular access-related reasons in the study group as compared to the baseline group (OR 1.6, 95% CI: 1.10 to 2.29, P = 0.014). …”
Publicado 2023
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20794por Sohail, Ramsha, Hassan, Imran H, Rukh, Mah, Saqib, Muhammad, Iftikhar, Muhammad, Mumtaz, Hassan“…Various descriptive variables were collected, including gender, tobacco use (specifically, chewed tobacco), underlying etiology, presence of anemia, leukopenia, pancytopenia, infectious state, and liver cirrhosis diagnosed via traditional ultrasonography. …”
Publicado 2023
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20795por Dhabhai, Neeta, Chowdhury, Ranadip, Virmani, Anju, Chaudhary, Ritu, Taneja, Sunita, Mittal, Pratima, Dewan, Rupali, Dang, Arjun, Kaur, Jasmine, Bhandari, Nita“…These findings highlight the need in early pregnancy for universal TSH screening and adequate treatment of hypothyroidism; as well as for attempts to reduce pre and peri-conception overweight, obesity and anemia. Clinical trial registration: Clinical trial registration of Women and Infants Integrated Interventions for Growth Study Clinical Trial Registry–India, #CTRI/2017/06/008908; Registered on: 23/06/2017, (http://ctri.nic.in/Clinicaltrials/pmaindet2.php?…”
Publicado 2023
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20796por Waworuntu, Wiendra, Tanoerahardjo, Francisca Srioetami, Mallongi, Anwar, Ahmad, Ahyar, Amin, Muhammad, Djaharuddin, Irawaty, Bukhari, Agussalim, Tabri, Nur Ahmad, Bahar, Burhanuddin, Hidayah, Najdah, Halik, Handayani, Massi, Muhammad Nasrum“…The research aimed to investigate iron deficiency anemia in TB patients and household contacts and its association with natural resistance‐associated macrophage protein 1 (NRAMP1) polymorphism and expression. …”
Publicado 2023
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20797por Shah, Nadia, Zaheer, Sidra, Safdar, Nilofer Fatimi, Turk, Tahir, Hashmi, Shahkamal“…RESULTS: Significant differences (p<0.001) were identified between intervention and control groups with women attending kitchen garden being more aware of the components of kitchen garden (65.8% vs 36.8%), and more knowledgeable about causes of illnesses caused by poor nutrition including, iron deficiency anemia, pregnancy, and unborn child health complications, compared to women not attending kitchen gardens program. …”
Publicado 2023
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20798por Mascarenhas, John, Migliaccio, Anna Rita, Kosiorek, Heidi, Bhave, Rupali, Palmer, Jeanne, Kuykendall, Andrew, Mesa, Ruben, Rampal, Raajit K., Gerds, Aaron T., Yacoub, Abdulraheem, Pettit, Kristen, Talpaz, Moshe, Komrokji, Rami, Kremyanskaya, Marina, Gonzalez, Agapito, Fabris, Frank, Johnson, Kathryn, Dougherty, Mikaela, McGovern, Erin, Arango Ossa, Juan, Domenico, Dylan, Farnoud, Noushin, Weinberg, Rona Singer, Kong, Amy, Najfeld, Vesna, Vannucchi, Alessandro Maria, Arciprete, Francesca, Zingariello, Maria, Falchi, Mario, Salama, Mohamed E., Mead-Harvey, Carolyn, Dueck, Amylou, Varricchio, Lilian, Hoffman, Ronald“…RESULTS: No dose-limiting toxicity was identified at the three dose levels tested, and grade 3/4 anemia and thrombocytopenia occurred in 28.6% and 19.0% of treated patients, respectively. …”
Publicado 2023
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20799Publicado 2023“…The main hematologic adverse reactions included grade 3–4 leukopenia(27.8%, with febrile neutropenia observed in 8.3% of patients), grade 3–4 lymphopenia(23.6%), grade 3–4 anemia(5.6%), and grade 3–4 thrombocytopenia(4.2%). …”
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20800“…Several PZFIs, including Pre-mRNA-splicing factor (SlSMP1/PZFI4), PAPA-1-like conserved region family protein (PZFI6), Fanconi anemia complex components (PZFI3 and PZFI10) and bHLH transcription factor LONESOME HIGHWAY (SlLHW/PZFI14), are putatively involved in cell cycle regulation. …”
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