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22341por Kim, Sung-Eun, Jang, Eun Sun, Ki, Moran, Gwak, Geum-Youn, Kim, Kyung-Ah, Kim, Gi-Ae, Kim, Do Young, Kim, Dong Joon, Kim, Man Woo, Kim, Yun Soo, Kim, Young Seok, Kim, In Hee, Kim, Chang Wook, Kim, Ho Dong, Kim, Hyung Joon, Park, Neung Hwa, Baik, Soon Koo, Suh, Jeong Ill, Song, Byung-Cheol, Song, Il Han, Yeon, Jong Eun, Lee, Byung Seok, Lee, Youn Jae, Jung, Young Kul, Chung, Woo Jin, Cho, Sung Bum, Cho, Eun-Young, Cho, Hyun Chin, Cheon, Gab Jin, Chae, Hee Bok, Choi, DaeHee, Choi, Sung-Kyu, Choi, Hwa Young, Tak, Won Young, Heo, Jeong, Jeong, Sook-Hyang“…In the multivariate analysis, HBsAg positivity was an independent factor associated with GFR < 60 mL/min/1.73 m(2) along with age, blood levels of albumin, bilirubin, anemia, and hemoglobin A1c (HbA1c). Likewise, HBsAg positivity was an independent factor for proteinuria along with age, male, blood levels of bilirubin, protein, albumin, and HbA1c. …”
Publicado 2018
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22342por Schipp, Cyrill, Schlütermann, David, Hönscheid, Andrea, Nabhani, Schafiq, Höll, Jessica, Oommen, Prasad T., Ginzel, Sebastian, Fleckenstein, Bernhard, Stork, Björn, Borkhardt, Arndt, Stepensky, Polina, Fischer, Ute“…Patient P2 experienced recurrent otitis in childhood, but when she presented at the age of 14, she showed clinical and immunological characteristics similar to patients suffering from Autoimmune Lymphoproliferative Syndrome (ALPS): elevated DNT cell number, non-malignant lymphadenopathy and hepatosplenomegaly, hematolytic anemia, hypergammaglobulinemia. Also patient P1 presented with ALPS-like features (lymphadenopathy, elevated DNT cell number and increased Vitamin B12 levels) and both were initially clinically diagnosed as ALPS-like. …”
Publicado 2018
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22343“…Duration of surgery was less than 2 h in 67.8% of the procedures. Anemia is the commonest complication (80.3%) followed by wound infection and VVF (11.7% each). …”
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22344“…In particular, our results suggested that the Fanconi anemia pathway had an important role in breast cancer prognosis. …”
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22345por Xia, Ze-Nan, Xiao, Ke, Zhu, Wei, Feng, Bin, Zhang, Bao-Zhong, Lin, Jin, Qian, Wen-Wei, Jin, Jin, Gao, Na, Qiu, Gui-Xing, Weng, Xi-Sheng“…Our study suggested that a direct surgery without preoperative use of therapeutic anticoagulation for ICMVT would not reduce the risk of thrombus extension, and the therapeutic use of anticoagulation may worsen postoperative anemia.…”
Publicado 2018
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22346por Fogelman, David, Cubillo, Antonio, García‐Alfonso, Pilar, Mirón, María Luisa Limón, Nemunaitis, John, Flora, Daniel, Borg, Christophe, Mineur, Laurent, Vieitez, Jose M., Cohn, Allen, Saylors, Gene, Assad, Albert, Switzky, Julie, Zhou, Li, Bendell, Johanna“…The most common hematologic adverse event was anemia. No new safety signals with ruxolitinib were identified. …”
Publicado 2018
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22347por Yamato, Osamu, Tsuneyoshi, Tadamitsu, Ushijima, Mitsuyasu, Jikihara, Hiroshi, Yabuki, Akira“…BACKGROUND: Plants of Allium spp., including garlic (A. sativum) and onions (A. cepa), are known to be oxidatively toxic to canine erythrocytes resulting in Heinz body hemolytic anemia in dogs. In humans, these plants have been used as medicinal agents for multiple diseases since ancient times. …”
Publicado 2018
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22348por Laar, Amos K., Lartey, Margaret Y., Ankomah, Augustine, Okyerefo, Michael P. K., Ampah, Ernest A., Letsa, Demi P., Nortey, Priscillia A., Kwara, Awewura“…The only predictor for food elimination was education level (AOR = 0.29; 95% CI 0.30–0.92); predictors of food substitution were ART clinic location (AOR = 0.11; 95% CI 0.02–0.69) and anemia (defined as hemoglobin concentration less than 11.0 g/dl) (AOR = 0.21; 95% CI 0.12–0.85). …”
Publicado 2018
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22349“…The rates of nausea, diarrhea, thrombocytopenia, pneumonitis, anorexia, anemia, febrile neutropenia were much the same in the 2 groups (RR = 1.35, 95% CI: 0.68–2.68, P = .38; RR = 1.85, 95% CI: 0.61–5.60, P = .28; RR = 1.67, 95% CI: 0.88–3.17, P = .12; RR = 1.19, 95% CI: 0.44–3.21, P = .73; RR = 1.35, 95% CI: 0.68–2.68, P = .38; RR = 0.86, 95% CI:0.55–1.34, P = .50; RR = 0.63, 95% CI:0.35–1.14, P = .13;, respectively). …”
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22350“…One SNP (p.R559H) had markedly low purification yield indicating enzyme instability as the likely cause for XLSA in an elderly patient with x-linked sideroblastic anemia. The five novel ALAS2 truncation mutations had increased V(max) values for both succinyl-CoA and glycine substrates (1.4 to 5.6-fold over wild-type), while the K(m)s for both substrates were only modestly changed. …”
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22351por Boku, N, Ryu, M -H, Kato, K, Chung, H C, Minashi, K, Lee, K -W, Cho, H, Kang, W K, Komatsu, Y, Tsuda, M, Yamaguchi, K, Hara, H, Fumita, S, Azuma, M, Chen, L -T, Kang, Y -K“…Most frequent (>10%) grade 3/4 treatment-related adverse events were neutropenia (14.3%) in the nivolumab plus SOX group, and neutropenia (16.7%), anemia, peripheral sensory neuropathy, decreased appetite, type 1 diabetes mellitus, and nausea (11.1% each) in the nivolumab plus CapeOX group. …”
Publicado 2019
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22352por Pesenti, Christian, Bories, Erwan, Caillol, Fabrice, Ratone, Jean Philippe, Godat, Sebastien, Monges, Genevieve, Poizat, Flora, Raoul, Jean Luc, Ries, Pauline, Giovannini, Marc“…They were discovered after anemia (n = 5), dysphagia (n = 1), and pain (n = 4) and during follow-up for resected gastrointestinal stromal tumors (GISTs) (n = 1) and a standard upper gastrointestinal endoscopy (n = 3). …”
Publicado 2019
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22353por Pokeerbux, M. R., Giovannelli, J., Dauchet, L., Mouthon, L., Agard, C., Lega, J. C., Allanore, Y., Jego, P., Bienvenu, B., Berthier, S., Mekinian, A., Hachulla, E., Launay, D.“…Age at diagnosis > 60 years, diffuse cutaneous SSc, scleroderma renal crisis, dyspnea, 6-min walking distance (6MWD), forced vital capacity < 70%, diffusing capacity of the lungs for carbon monoxide < 70%, pulmonary hypertension (PH), telangiectasia, valvular disease, malignancy, anemia, and CRP > 8 mg/l were associated with a poorer survival after adjustment. …”
Publicado 2019
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22354por Saffari, Afshin, Brösse, Ines, Wiemer-Kruel, Adelheid, Wilken, Bernd, Kreuzaler, Paula, Hahn, Andreas, Bernhard, Matthias K., van Tilburg, Cornelis M., Hoffmann, Georg F., Gorenflo, Matthias, Hethey, Sven, Kaiser, Olaf, Kölker, Stefan, Wagner, Robert, Witt, Olaf, Merkenschlager, Andreas, Möckel, Andreas, Roser, Timo, Schlump, Jan-Ulrich, Serfling, Antje, Spiegler, Juliane, Milde, Till, Ziegler, Andreas, Syrbe, Steffen“…Grade 1–2 adverse events occurred in 12 patients and included mild transient stomatitis (2 cases), worsening of infantile acne (1 case), increases of serum cholesterol and triglycerides (4 cases), changes in serum phosphate levels (2 cases), increase of cholinesterase (2 cases), transient neutropenia (2 cases), transient anemia (1 case), transient lymphopenia (1 case) and recurrent infections (7 cases). …”
Publicado 2019
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22355por Conroy, Andrea L., Opoka, Robert O., Bangirana, Paul, Idro, Richard, Ssenkusu, John M., Datta, Dibyadyuti, Hodges, James S., Morgan, Catherine, John, Chandy C.“…METHODS: Ugandan children with cerebral malaria (CM, n = 260) and severe malaria anemia (SMA, n = 219) or community children (CC, n = 173) between 1.5 and 12 years of age were enrolled in a prospective cohort study. …”
Publicado 2019
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22356por Swindell, William R., Kruse, Colin P. S., List, Edward O., Berryman, Darlene E., Kopchick, John J.“…ALS-decreased DEGs, in contrast, had low exosome expression, were erythroid lineage-specific, and associated with anemia and blood disorders. Genes encoding neurofilament proteins (NEFH, NEFL) had poor diagnostic accuracy (50–53%). …”
Publicado 2019
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22357por Sigal, Winnie, Williams, Cheyenne, Joshi, Apoorva, Stanescu, Diana, Hatch-Stein, Jacquelyn, Pinney, Sara“…Her hospital course was complicated by respiratory failure, impaired immune function, chronic diarrhea due to pancreatic exocrine deficiency, anemia, and primary adrenal insufficiency. Whole exome sequencing revealed a novel, de novo missense mutation in SAMD9 (R1293Q), confirming the clinical diagnosis of MIRAGE syndrome. …”
Publicado 2019
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22358“…Three days later, he was readmitted for altered mental status and anemia. He was hypoglycemic, which was new on readmission, and required dextrose-containing IV fluids in addition to tube feeds to keep his serum glucose within normal range. …”
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22359por Agarwalla, Avinesh, Gowd, Anirudh K., Yao, Kaisen, Bohl, Daniel D., Amin, Nirav H., Verma, Nikhil N., Forsythe, Brian, Liu, Joseph N.“…After adjusting for demographic and procedural characteristics, a 15-minute increase in operative duration was associated with an increased risk of anemia requiring transfusion (relative risk [RR], 1.27 [95% CI, 1.14-1.42]; P < .001), venous thromboembolism (RR, 1.17 [95% CI, 1.02-1.35]; P = .029), surgical site infection (RR, 1.13 [95% CI, 1.03-1.24]; P = .011), and extended length of hospital stay (RR, 1.07 [95% CI, 1.00-1.14]; P = .036). …”
Publicado 2019
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22360por Gustafson, Margaret A., McCormick, Elizabeth M., Perera, Lalith, Longley, Matthew J., Bai, Renkui, Kong, Jianping, Dulik, Matthew, Shen, Lishuang, Goldstein, Amy C., McCormack, Shana E., Laskin, Benjamin L., Leroy, Bart P., Ortiz-Gonzalez, Xilma R., Ellington, Meredith G., Copeland, William C., Falk, Marni J.“…Here, we report a 14-year-old Chinese boy with severe and progressive mitochondrial disease manifestations across the full Pearson, Kearns-Sayre, and Leigh syndromes spectrum, including infantile anemia and bone marrow failure, growth failure, ptosis, ophthalmoplegia, ataxia, severe retinal dystrophy of the rod-cone type, sensorineural hearing loss, chronic kidney disease, multiple endocrine deficiencies, and metabolic strokes. mtDNA genome sequencing identified a single large-scale 5 kilobase mtDNA deletion (m.8629_14068del5440), present at 68% and 16% heteroplasmy in the proband’s fibroblast cell line and blood, respectively, suggestive of a mtDNA maintenance defect. …”
Publicado 2019
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