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22421por Foldi, Julia, Silber, Andrea, Reisenbichler, Emily, Singh, Kamaljeet, Fischbach, Neal, Persico, Justin, Adelson, Kerin, Katoch, Anamika, Horowitz, Nina, Lannin, Donald, Chagpar, Anees, Park, Tristen, Marczyk, Michal, Frederick, Courtney, Burrello, Trisha, Ibrahim, Eiman, Qing, Tao, Bai, Yalai, Blenman, Kim, Rimm, David L., Pusztai, Lajos“…In Phase II, pCR rate was 44% (95% CI: 30–57%); 18 patients (31%) experienced grade 3/4 treatment-related adverse events (AE), most frequently neutropenia (n = 4) and anemia (n = 4). Immune-related grade 3/4 AEs included Guillain–Barre syndrome (n = 1), colitis (n = 2), and hyperglycemia (n = 2). …”
Publicado 2021
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22422por Langer, Corey J., Gajra, Ajeet, Gridelli, Cesare, Konduri, Kartik, Morgensztern, Daniel, Spigel, David, Talbot, Denis, Thomas, Michael, Weiss, Jared, Pilot, Richard, Bhore, Rafia, Wolfsteiner, Marianne, Ong, Teng Jin, Socinski, Mark“…The most common grade 3/4 hematologic adverse events in patients with renal impairment, elderly patients, patients with diabetes, and patients with poor performance status included neutropenia, anemia, and thrombocytopenia. CONCLUSIONS: Although survival data in patients with ECOG PS 2 were notably inferior to the other cohorts, our findings are consistent with those previously reported in the population-specific studies of the ABOUND trials and lend additional support for the use of nab-paclitaxel–based regimens in historically understudied and vulnerable populations.…”
Publicado 2021
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22423por Cheng, Linlin, Li, Yang, Wu, Ziyan, Li, Liubing, Liu, Chenxi, Liu, Jianhua, Dai, Jiayu, Zheng, Wenjie, Zhang, Fengchun, Tang, Liujun, Yu, Xiaobo, Li, Yongzhe“…We determined that total protein/mean corpuscular hemoglobin and total protein/mean corpuscular hemoglobin levels, total protein/mean corpuscular volume, and plateletcrit/monocyte counts were significantly increased in BD compared with controls (P < 0.05, in both the discovery and validation sets), which helped in distinguishing BD patients from healthy and vasculitis controls. Chronic anemia in BD combined with increased total protein contributed to higher levels of these biomarkers, and the interactions between platelets and monocytes may be linked to vascular involvement. …”
Publicado 2021
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22424por Yamazaki, Susumu, Akutsu, Yuko, Shimbo, Asami, Shimizu, Masaki, Segawa, Yuko, Mori, Masaaki“…Furthermore, thrombocytopenia, anemia, and erythrocyte fragmentation were detected, suggesting secondary thrombotic microangiopathy. …”
Publicado 2021
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22425“…Grade≥2 fatigue, dysgeusia, oral mucositis, constipation, peripheral neuropathy, anemia arthralgia/myalgia, dry mouth, diarrhea, constipation, and/or skin hyperpigmentation were positively predicted for the deterioration of symptoms scale of EORTC QLQ-C30 and BR23 (4.819≤B≤26.451, P≤0.043). …”
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22426“…PLD plus carbo was associated with significantly more anemia and thrombocytopenia, and other side effects were well tolerated. …”
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22427“…There was no case associated with complications of anemia. CONCLUSIONS: Hip fracture surgery in patients with hemoglobin less than 10 g/dL was feasible without the need for transfusion using our PBM protocol in 34 patients. …”
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22428“…BACKGROUND: Globally, about 25% of children suffer from subclinical vitamin A deficiency (VAD), and approximately 300 million children globally had anemia as per 2011 estimates. Micronutrient deficiencies are generally referred to as “hidden hunger” because these deficiencies developed gradually. …”
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22429por Sukwa, Nsofwa, Simuyandi, Michelo, Chirwa, Masuzyo, Kumwimba, Yvonne Mutombo, Chilyabanyama, Obvious N., Laban, Natasha, Koyuncu, Aybüke, Chilengi, Roma“…The mean age at diagnosis was 4.5 months (1.3 months standard deviation), and the common presenting features included coryza (6/7), skin lesions (4/7), conjunctivitis (3/7), pallor/anemia (5/7), wasting (2/7), and underweight (5/7). …”
Publicado 2021
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22430por Bosch, Xavier, Capdevila, Aina, Grafia, Ignacio, Ladino, Andrea, Moreno, Pedro J., López-Soto, Alfonso“…Compared to other cohorts, pandemic cohort patients were more likely to have unintentional weight loss and fever of unknown origin as referral indications while anemia and lymphadenopathy were less common. Patients from the pandemic cohort had a significantly lower rate of malignancies and higher of benign gastrointestinal disorders (40.93% vs. 19.53% and 20.89% in prepandemic and postpandemic periods, respectively; P < 0.001 in both), most notably irritable bowel disease, and of mental and behavioral disorders (15.54% vs. 3.39% and 6.00% in prepandemic and postpandemic periods, respectively; P < 0.001 in both). …”
Publicado 2021
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22431por Pignata, Sandro, Scambia, Giovanni, Villanucci, Alessandro, Naglieri, Emanuele, Ibarbia, Mikel Arruti, Brusa, Federica, Bourgeois, Hugues, Sorio, Roberto, Casado, Antonio, Reichert, Dietmar, Dopchie, Catherine, De Rivas, Beatriz, de Sande, Luis Miguel“…Most common grade 3/4 adverse events (AEs) were neutropenia (30.3%), anemia (6.4%), thrombocytopenia (5.5%), and asthenia (5.0%). …”
Publicado 2021
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22432por Chen, Li, Bai, Ping, Kong, Xiangyi, Huang, Shaolong, Wang, Zhongzhao, Wang, Xiangyu, Fang, Yi, Wang, Jing“…The common toxicities after neoadjuvant chemotherapy were hematologic and gastrointestinal reaction, and the PNI had no significance on the toxicities of all enrolled patients, except in anemia, leukopenia, and myelosuppression. CONCLUSION: Pretreatment PNI with the advantages of being convenient, noninvasive, and reproducible was a useful prognostic indicator for breast cancer patients receiving neoadjuvant chemotherapy and is a promising biomarker for breast cancer on treatment strategy decisions.…”
Publicado 2021
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22433por Hu, Peng-yi, Zhong, Ying-huai, Feng, Jian-fang, Li, Dong-xun, Deng, Ping, Zhang, Wen-liu, Lei, Zhi-qiang, Liu, Xue-mei, Zhang, Guo-song“…Chaxiong has been used to treat cardiovascular and cerebrovascular diseases, atherosclerosis, anemia and stroke. A high purity extract from chaxiong (VOC, brownish yellow oil) was extracted and separated. …”
Publicado 2021
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22434Publicado 2021“…METHODS: ①Peripheral blood mononuclear cells(PBMC)of 30 patients with relapsed/refractory B-cell acute lymphoblastic anemia(R/R B-ALL)who accepted CD19 CAR-T cell therapy and six healthy volunteers were collected. ②The residual leukemia cells were analyzed by flow cytometry in the system after the PBMCs of R/R B-ALL patients were sorted by CD3 magnetic beads. ③ CD3(+) T cells from patients and healthy volunteers were transfected with CD19 CAR and CD22 CAR lentivirus to prepare CD19 CAR-T and CD22 CAR-T cells. ④The Nalm-6 cell line was resuscitated and the Nalm-6 cells with CD19 CAR lentivirus were transfected to prepare CD19 CAR-Nalm-6 cells. …”
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22435por Driouk, Lina, Schmitt, Robert, Peters, Anke, Heine, Sabine, Girschick, Hermann Josef, Strahm, Brigitte, Niemeyer, Charlotte M., Speckmann, Carsten“…Patient 2 (P2), a 6-year-old boy with CD40 ligand (CD40L) deficiency, developed both AIT and hemolytic anemia (AIHA) after HSCT on days +58 and +83, respectively, and was also treated with daratumumab after being previously refractory to prednisolone, rituximab, and IVIG. …”
Publicado 2021
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22436por Iwuala, Sandra Omozehio, Kirupakaran, Johnathan, Trusty, Rhonda, Curry, Sumarah, Williams, Belinda, Daruwala, Orpah, Fenton, Franklyn, Bahtiyar, Gul, Rodriguez, Giovanna“…Clinical case: 18 year old man with history of iron deficiency anemia and dyslipidemia presented with aphasia, right sided upper and lower extremity weakness and facial tingling for 3 days. …”
Publicado 2021
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22437por Abdelmasih, Randa, Abdelmaseih, Ramy, Monsour, Elio Paul, Hasan, S Mustajab, Vesely, Josef James Karl“…Indications of parathyroidectomy in ESRD patients include persistent elevation of PTH more than 800, Calcyphylaxis, Osteitis Fibrosa Cystica, and persistent anemia. Among these patients who require surgery, 5–20% present with persistent or recurrent disease and require further re-exploration and excision of parathyroid tissue. …”
Publicado 2021
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22438“…Clinical Case: A 67-year-old man with Crohn’s disease status post remote ileocolonic resection, malnutrition (BMI 16.7), anemia, history of hypovitaminosis D, secondary hyperparathyroidism, and severe osteoporosis, was advised to present to the emergency room for hypocalcemia and hypophosphatemia after routine lab draw. …”
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22439“…Lab results showed macrocytic anemia, otherwise normal metabolic panel. ANA, anti-Scl-70, and anticentromere antibodies were negative. …”
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22440por Radovanovic, Natasa, De Castro, Alicia, Cao, Yenong, Ammana, Hima Reddy, Kwak, Leigh“…At this point he developed multiple complications due to progressive metastatic disease including acute urinary retention, shortness of breath, abdominal pain, tachycardia, acute anemia and thrombocytopenia, anxiety and was started on methimazole as part of palliative treatment for symptom relief. …”
Publicado 2021
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