Mostrando 258,801 - 258,820 Resultados de 259,932 Para Buscar '"animal"', tiempo de consulta: 1.77s Limitar resultados
  1. 258801
  2. 258802
  3. 258803
  4. 258804
    “…Methods: Female Wistar rats were submitted to stereotaxic surgery for implantation of a guide cannula into the mPOA 7 days prior to the experiments. Afterwards, the animals were isoflurane- anesthetized and submitted to the catheterization of the femoral artery and vein and urinary bladder cannulation for mean arterial pressure (MAP), heart rate (HR), and intravesical pressure (IP) recordings, respectively. …”
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  5. 258805
  6. 258806
    “…Finally, diaphragm contractile force and motion parameters (excursion amplitude, inspiratory velocity, and expiratory velocity) declined with duration of obesity in WT mice, but, remained unchanged in Thbs1(-/-) animals. These data define THBS-1 as a novel regulator of diaphragm stromal remodeling and potential therapeutic target for mitigating obesity-associated respiratory dysfunction. …”
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  7. 258807
    “…We have found that knockout (KO) of PARP1 in the monocyte/macrophage lineage (i.e., using a LysM-Cre driver) results in dramatic weight gain in mice with a nearly 2-fold increase in fat body mass in animals fed a high fat diet. Further analysis revealed decreases in adipose-associated macrophages and adipose hypertrophy, as well as increased hepatic lipid accumulation. …”
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  8. 258808
    “…However, abnormally elevated androgen levels reduce fertility in humans and animals, suggesting that a delicate equilibrium exists between the beneficial and harmful effects of androgens in the ovary. …”
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  9. 258809
    “…Importantly, RO (20-40 mg/kg/day; ip) significantly suppressed tumor xenografts derived from ovarian cancer cells (SK-OV-3; 336 + 60 mm(3) vs 171 + 20 mm(3)) with no toxicity to experimental animals (27 treatments once tumors reached 100 mm(3)). …”
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  10. 258810
    “…Gestational hyperandrogenism such as that seen in Polycystic Ovary Syndrome (PCOS), leads to adverse offspring health outcomes in both humans and animals. Prenatal T excess (T) in a sheep model of PCOS phenotype induces peripheral insulin resistance, dyslipidemia, adipocyte defects, liver steatosis, pathological cardiac remodeling and hypertension in the female offspring. …”
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  11. 258811
    “…In general, we observed a significant difference in maternal and fetal T(3) levels at GD15 and GD20 in control, low, and high dose-exposed animals. At GD15, there was a significant difference between maternal and fetal female placental T(4) levels (p=0.0237) and a suggestive difference in males (p=0.081) in the high dose group, as well as a significant effect of sex between the fetal tissues in the low dose group (p=0.0044). …”
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  12. 258812
    “…In bovine ovaries, the cortex, housing PMFs, is 8.5 times more rigid than deep medulla and is comprised of differential matrisome proteins. As mono-ovulatory animals, their ovaries closely mimic humans, making them a suitable model. …”
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  13. 258813
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  17. 258817
  18. 258818
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