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  1. 4841
    “…The analysis of loss- and gain-of-function mutant animals revealed that this factor plays a crucial role in the endocrine pancreas. …”
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    Generation of animals allowing the conditional inactivation of the Pax4 gene
  2. 4842
    “…As discussed herein, understanding these differences and the novel properties of the toxins is imperative for clinical management decisions, design of appropriate animal models, and choices of adjunctive therapeutics. …”
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    Shiga Toxins and the Pathophysiology of Hemolytic Uremic Syndrome in Humans and Animals
  3. 4843
    “…A group of promising candidates of this category would be venom-toxins of animal origin of potential medicinal value. Traditional systems of medicine as well as folklores mention the use of venom-toxins for the treatment of various diseases. …”
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    Nanoparticle-conjugated animal venom-toxins and their possible therapeutic potential
  4. 4844
    “…The present study aimed to investigate the anti-inflammatory effect of Yanshu in xylene-induced ear edema in mice and carrageenan-induced paw edema in rats by measuring the degree of edema in the animal models. The histopathology and the levels of prostaglandin E2 (PGE2) and cycloxygenase-2 (COX-2) in the hind paws of the carrageenan-treated rats were also analyzed. …”
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    Anti-inflammatory activity of Yanshu spraying agent in animal models
  5. 4845
    “…Their ability to efficiently deliver transgenes to multi-lineage long-term repopulating cells in large animal models suggests they will be effective for several human hematopoietic diseases. …”
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    Large Animal Models for Foamy Virus Vector Gene Therapy
  6. 4846
    “…Furthermore, GRN-deficient animal models have been established and they are believed to be promising disease models as they show accelerated aging and recapitulate at least some neuropathological features of FTD. …”
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    Mechanisms of Granulin Deficiency: Lessons from Cellular and Animal Models
  7. 4847
    “…In this paper we will discuss the endogenous stem cell response to SCI in animal models. All SCI animal models experience a similar peak of cell proliferation three days after injury; however, each specific type of injury promotes a specific and distinct stem cell response. …”
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    Endogenous Proliferation after Spinal Cord Injury in Animal Models
  8. 4848
    “…Since the central serotonergic dysfunction is an important and well-known cause mediating the pathophysiology of trauma-related symptoms in PTSD, it is reasonable to predict that flavonoids may exert therapeutic effects on PTSD in animal models. Therefore, the present study aims to examine the effect of flavonoids in alleviating the enhanced anxiety and fear response induced in two PTSD animal models. …”
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    Anxiolytic Effects of Flavonoids in Animal Models of Posttraumatic Stress Disorder
  9. 4849
    “…While it is clear that some human gut bacterial pathogens come from animals (showing that human – animal transmission occurs), the extent to which the usually non-pathogenic commensal taxa are shared between humans and animals has not been explored. …”
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    Comparison of the Distal Gut Microbiota from People and Animals in Africa
  10. 4850
    “…The One Health paradigm for global health recognizes that most new human infectious diseases will emerge from animal reservoirs. Little consideration has been given to the known and potential zoonotic infectious diseases of small companion animals. …”
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    Surveillance of Zoonotic Infectious Disease Transmitted by Small Companion Animals
  11. 4851
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    Retraction: progress of genome wide association study in domestic animals
  12. 4852
    “…Advances in molecular biotechnology have introduced new generations of molecular markers for use in the genetic improvement of farm animals. Consequently, more accurate genetic information can be obtained to better understand existing animal genetic resources. …”
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    Review on the development of genotyping methods for assessing farm animal diversity
  13. 4853
    “…Furthermore, acute striatal l-DOPA administration attenuated glutamate release in all groups, except in the dopamine-lesioned striatum of dyskinetic animals. Co-administration of 8-OHDPAT and l-DOPA decreased dyskinesia in dopamine-lesioned animals, but did not affect potassium-evoked glutamate release, which was seen in normal animals. …”
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    Striatal Glutamate Release in l-DOPA-Induced Dyskinetic Animals
  14. 4854
    “…In this review we explore the use of animal smoke exposure models and their insight into disease pathogenesis. …”
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    Second hand smoke and COPD: lessons from animal studies
  15. 4855
    por Sameshima, Hiroshi, Ikenoue, Tsuyomu
    Publicado 2013
    “…In this paper, we would like to share some of the results of our recent studies on neuroprotective therapies in animal experiments, as well as some literature reviews. …”
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    Hypoxic-Ischemic Neonatal Encephalopathy: Animal Experiments for Neuroprotective Therapies
  16. 4856
    “…Vaccination has proven to be the most cost-effective strategy for controlling a wide variety of infectious diseases in humans and animals. For the last decade, veterinary vaccines have been substantially developed and demonstrated their effectiveness against many diseases. …”
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    A review of vaccine development and research for industry animals in Korea
  17. 4857
    por Mol, Jan A
    Publicado 2013
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    Comparative breast cancer research, lessons from companion animals
  18. 4858
    “…One requirement facilitating FSGS research is an animal model that resembles human FSGS. Most animal models induce secondary forms of FSGS in an acute manner. …”
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    Pathophysiology and treatment of focal segmental glomerulosclerosis: the role of animal models
  19. 4859
    “…BACKGROUND: Systematic reviews and meta-analyses of pre-clinical studies, in vivo animal experiments in particular, can influence clinical care. …”
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    Publication bias in animal research: a systematic review protocol
  20. 4860
    por Blagosklonny, Mikhail V.
    Publicado 2013
    “…It has been known for millennia that large animals live longer, inspiring numerous theories of aging. …”
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    Big mice die young but large animals live longer
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