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4861por da Silva Xavier, Gabriela, Bellomo, Elisa A., McGinty, James A., French, Paul M., Rutter, Guy A.“…Whilst mouse models have in the past been central to understanding the mechanisms through which more penetrant risk genes for T2D, for example, those responsible for neonatal or maturity-onset diabetes of the young, only a few of those identified by GWAS, notably TCF7L2 and ZnT8/SLC30A8, have to date been examined in mouse models. We discuss here the animal models available for the latter genes and provide perspectives for future, higher throughput approaches towards efficiently mining the information provided by human genetics.…”
Publicado 2013
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4862“…This review summarizes the evidences for the therapeutic potential of ginseng and ginsenosides from in vitro studies, animal studies and human clinical trials with a focus on diverse molecular targets including an AMP-activated protein kinase signaling pathway.…”
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4863“…This review examines the symptoms, mechanisms, and clinical therapeutic options in these conditions and highlights the value of EAE and EAN animal models for the study of neuropathic pain in MS and GBS.…”
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4864
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4865“…Fortunately, much effort has focused on developing animal models to help study the pathophysiology of PTSD. …”
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4866“…The purpose of this review is to give an insight on factors associated with echinococcosis in animal hosts by summarising significant results reported from epidemiological studies identified through a systematic search. …”
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4867“…Several nanoparticles exhibit detrimental effects on female reproductivity as well as fetal development, and these adverse effects are related to nanoparticle composition, surface modification, dose, exposure route and animal species. Limited studies on the mechanisms of nanotoxicity are also documented and reviewed herein.…”
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4868“…Samples (serum or meat juice) collected from 205 animals in New Caledonia in April 2009 were tested for antibodies against Toxoplasma gondii by ELISA using the multi-species ID Screen(®) Toxoplasmosis Indirect kit (IDVET, Montpellier). …”
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4869
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4870
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4871por Burns, Carol J., McIntosh, Laura J., Mink, Pamela J., Jurek, Anne M., Li, Abby A.“…Suggestions for improved exposure assessment in epidemiology studies and more effective and tiered approaches in animal testing are discussed.…”
Publicado 2013
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4872por Hajiaghaalipour, Fatemeh, Kanthimathi, M. S., Abdulla, Mahmood Ameen, Sanusi, Junedah“…A uniform area of 2.00 cm in diameter was excised from the neck of adult male Sprague Dawley rats. The animals were topically treated with 0.2 mL of vehicle (CMC), Intrasite gel (positive control), or 200 and 400 mg/mL of extract. …”
Publicado 2013
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4873por Bezold, Katherine Y, Karjalainen, Minna K, Hallman, Mikko, Teramo, Kari, Muglia, Louis J“…So far, the application of animal models to understand human birth timing has not substantially revealed mechanisms that could be used to prevent prematurity. …”
Publicado 2013
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4874por Tsilidis, Konstantinos K., Panagiotou, Orestis A., Sena, Emily S., Aretouli, Eleni, Evangelou, Evangelos, Howells, David W., Salman, Rustam Al-Shahi, Macleod, Malcolm R., Ioannidis, John P. A.“…Animal studies generate valuable hypotheses that lead to the conduct of preventive or therapeutic clinical trials. …”
Publicado 2013
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4875
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4876por Hagemo, Jostein S, Jørgensen, Jørgen J, Ostrowski, Sisse R, Holtan, Anders, Gundersen, Yngvar, Johansson, Pär I, Næss, Pål A, Gaarder, Christine“…CONCLUSION: Despite a reduction in clotting capability measured by ExTEM MCF and a reduced fibrinogen concentration, extensive tissue trauma may induce an increased fibrin based clotting activity that attenuates the hypocoagulable tendency in exsanguinated animals.…”
Publicado 2013
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4877
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4878por Towne, Chris, Montgomery, Kate L., Iyer, Shrivats M., Deisseroth, Karl, Delp, Scott L.Enlace del recurso
Publicado 2013
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4879por Suga, Hiroshi, Chen, Zehua, de Mendoza, Alex, Sebé-Pedrós, Arnau, Brown, Matthew W., Kramer, Eric, Carr, Martin, Kerner, Pierre, Vervoort, Michel, Sánchez-Pons, Núria, Torruella, Guifré, Derelle, Romain, Manning, Gerard, Lang, B. Franz, Russ, Carsten, Haas, Brian J., Roger, Andrew J., Nusbaum, Chad, Ruiz-Trillo, Iñaki“…To reconstruct the evolutionary origin of multicellular animals from their unicellular ancestors, the genome sequences of diverse unicellular relatives are essential. …”
Publicado 2013
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4880por Betts, Kellyn S.Enlace del recurso
Publicado 2013
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