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  1. 5381
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    Reinforcing involvement of NK cells in psoriasiform dermatitis animal model
  2. 5382
    por Bisset, Elise S., Howlett, Susan E.
    Publicado 2019
    “…Quantification of frailty with both “frailty phenotype” and “frailty index” approaches has begun to highlight putative frailty mechanisms and new animal models of frailty are inspiring preclinical research. …”
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    The biology of frailty in humans and animals: Understanding frailty and promoting translation
  3. 5383
    “…Wild animals are brought into captivity for many reasons—conservation, research, agriculture and the exotic pet trade. …”
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    Chronic captivity stress in wild animals is highly species-specific
  4. 5384
    por Chawengsaksophak, Kallayanee
    Publicado 2019
    “…This review will address how animal models have refined our understanding of the role of Cdx2 in these common human cancers.…”
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    Cdx2 Animal Models Reveal Developmental Origins of Cancers
  5. 5385
    por Decamp, G. W.
    Publicado 1868
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    Animal Heat: Read before the Central Ohio Dental Association
  6. 5386
    “…These sometimes employ custom genetic interventions such as antisense-mediated exon skipping or genome editing, aiming to restore protein function in a mutation-specific manner. Animal models can facilitate the development of personalized medicine approaches; however, given that they target human mutations and therefore human genetic sequences, scientists rely on the availability of humanized animal models. …”
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    The use of genetically humanized animal models for personalized medicine approaches
  7. 5387
    por Smith, Adrian J., Lilley, Elliot
    Publicado 2019
    “…To improve validity, scientists must collaborate closely with the animal facility involved as soon as the decision to use animals has been made. …”
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    The Role of the Three Rs in Improving the Planning and Reproducibility of Animal Experiments
  8. 5388
    “…This short review summarizes LCB biosynthesis with their associating metabolic pathways in animals, plants and fungi.…”
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    Biosynthesis of long chain base in sphingolipids in animals, plants and fungi
  9. 5389
    por Seekatz, Anna M.
    Publicado 2019
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    Development of an alternative animal model to investigate host-microbe interactions
  10. 5390
    “…Rats were subjected to CLP, and some animals were treated with minocycline (10 ug/kg) by i.c.v. administration. …”
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    Characterization and modulation of microglial phenotypes in an animal model of severe sepsis
  11. 5391
    “…BACKGROUND: Comparative genomics studies are central in identifying the coding and non-coding elements associated with complex traits, and the functional annotation of genomes is a critical step to decipher the genotype-to-phenotype relationships in livestock animals. As part of the Functional Annotation of Animal Genomes (FAANG) action, the FR-AgENCODE project aimed to create reference functional maps of domesticated animals by profiling the landscape of transcription (RNA-seq), chromatin accessibility (ATAC-seq) and conformation (Hi-C) in species representing ruminants (cattle, goat), monogastrics (pig) and birds (chicken), using three target samples related to metabolism (liver) and immunity (CD4+ and CD8+ T cells). …”
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    Multi-species annotation of transcriptome and chromatin structure in domesticated animals
  12. 5392
    por Shifflett, Kyle, Marzi, Andrea
    Publicado 2019
    “…Without field efficacy studies, researchers must rely on animal models of MARV infection to assess the efficacy of vaccines and treatments, with the limitations being the accuracy of the animal model in recapitulating human pathogenesis. …”
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    Marburg virus pathogenesis – differences and similarities in humans and animal models
  13. 5393
    “…SIMPLE SUMMARY: Preventing animal cruelty and neglect is the goal of animal protection. …”
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    Animal Cruelty and Neglect: Prevalence and Community Actions in Victoria, Australia
  14. 5394
    “…To explore the underlying mechanisms of VCI, several animal models of chronic cerebral hypoperfusion have been developed in rats, mice, and primates. …”
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    Animal Models of Chronic Cerebral Hypoperfusion: From Mouse to Primate
  15. 5395
    “…SIMPLE SUMMARY: The demand for products with higher farm animal welfare (FAW) standards is increasing within the European Union. …”
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    Fattening Pig Farmers’ Intention to Participate in Animal Welfare Programs
  16. 5396
    “…In each group, 7 animals were used for retinal function evaluation (ERG) and 6 animals were used for retinal structural evaluation (histology). …”
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    Functional and Structural Effects of Erythropoietin Subconjunctival Administration in Glaucomatous Animals
  17. 5397
    “…In the present review, we discuss potential pharmacological targets for OSA discovered using animal models.…”
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    The Role of Animal Models in Developing Pharmacotherapy for Obstructive Sleep Apnea
  18. 5398
    por Frey, Joachim
    Publicado 2019
    “…Exotoxins play a central role in the pathologies caused by most major bacterial animal pathogens. The large variety of vertebrate and invertebrate hosts in the animal kingdom is reflected by a large variety of bacterial pathogens and toxins. …”
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    RTX Toxins of Animal Pathogens and Their Role as Antigens in Vaccines and Diagnostics
  19. 5399
    por Hotinger, Julia A., May, Aaron E.
    Publicado 2019
    “…In vivo assays are required to study pathogens in their natural environment and are an important step in the development of new drugs and vaccines. Animal models are also required to understand whether T3SS inhibition will enable the host to clear the infection. …”
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    Animal Models of Type III Secretion System-Mediated Pathogenesis
  20. 5400
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    Establishing an animal model to investigate depression with coronary heart disease
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