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241“…The deregulation of apoptosis is involved in the development of several pathologies, and recent evidence suggests that apoptosis may be involved in chronic pain, namely in neuropathic pain. …”
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242“…A critical facet of the balance that facilitates platelet clearance from the circulation is apoptosis (programmed cell death). The precise cellular mechanisms that underpin platelet apoptosis are not defined. …”
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243por Yang, Shuo, Wang, Long, Wu, Yuesong, Wu, Anguo, Huang, Feihong, Tang, Xiaoqin, Kantawong, Fahsai, Anuchapreeda, Songyot, Qin, Dalian, Mei, Qibing, Chen, Jianping, Huang, Xinwu, Zhang, Chunxiang, Wu, Jianming“…Some researchers believe that apoptosis is an ally of thrombopoiesis and platelets production is apoptosis-dependent, while others have suggested that apoptosis is dispensable for thrombopoiesis, and is even inhibited during this process. …”
Publicado 2023
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244“…Previous works have indicated that apoptosis is the main reason for RGC death in glaucoma. …”
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245por Shankar, Sharmila, Chen, Qinghe, Sarva, Krishna, Siddiqui, Imtiaz, Srivastava, Rakesh K“…BACKGROUND: We have recently shown that curcumin (a diferuloylmethane) inhibits growth and induces apoptosis, and also demonstrated that TRAIL induces apoptosis by binding to specific cell surface death receptors in prostate cancer cells. …”
Publicado 2007
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246“…Many tumors overexpress members of the inhibitor of apoptosis protein (IAP) family. IAPs contribute to tumor cell apoptosis resistance by the inhibition of caspases, and are degraded by the proteasome to allow further progression of apoptosis. …”
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247por Herold, Susanne, Steinmueller, Mirko, von Wulffen, Werner, Cakarova, Lidija, Pinto, Ruth, Pleschka, Stephan, Mack, Matthias, Kuziel, William A., Corazza, Nadia, Brunner, Thomas, Seeger, Werner, Lohmeyer, Juergen“…We demonstrate for the first time that lung-recruited “exudate” macrophages significantly contribute to alveolar epithelial cell (AEC) apoptosis by the release of tumor necrosis factor–related apoptosis-inducing ligand (TRAIL) in a murine model of influenza-induced pneumonia. …”
Publicado 2008
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248por Tai, Cheng-Jeng, Hsu, Chung-Huei, Shen, Shing-Chuan, Lee, Woan-Ruoh, Jiang, Ming-Chung“…The cellular apoptosis susceptibility (CSE1L/CAS) protein is highly expressed in cancer, and its expression is positively correlated with high cancer stage, high cancer grade, and worse outcomes of patients. …”
Publicado 2010
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249por Jang, Tae-ho, Kim, Seong Hyun, Jeong, Jae-Hee, Kim, Sunghwan, Kim, Yeun Gil, Park, Hyun Ho“…Apoptosis repressor with caspase recruiting domain (ARC) is a multifunctional inhibitor of apoptosis that is unusually over-expressed or activated in various cancers and in the state of the pulmonary hypertension. …”
Publicado 2015
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250“…Gastric cancer (GC) remains one of the leading causes of cancer-associated mortality. Inhibitor of apoptosis-stimulating protein of p53 (iASPP) is a member of the inhibitory apoptosis-stimulating protein p53 family. …”
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251por Gao, Cheng, Yu, Hongwei, Yan, Cong, Zhao, Wenyang, Liu, Yao, Zhang, Dongdong, Li, Jingwei, Liu, Nan“…This study was designed to explore the role of X-linked inhibitor of apoptosis (XIAP) in early brain injury following SAH. …”
Publicado 2017
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252por Koval, Olga, Kochneva, Galina, Tkachenko, Anastasiya, Troitskaya, Olga, Sivolobova, Galina, Grazhdantseva, Antonina, Nushtaeva, Anna, Kuligina, Elena, Richter, Vladimir“…We have engineered a double recombinant VV, coding human GM-CSF, and apoptosis-inducing protein apoptin (VV-GMCSF-Apo) for comparing with the earlier constructed double recombinant VV-GMCSF-Lact, coding another apoptosis-inducing protein, lactaptin, which activated different cell death pathways than apoptin. …”
Publicado 2017
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253“…Apoptosis inhibition is a critical strategy of mycobacteria facilitating its survival in macrophages, but the underlying mechanism is not completely understood. …”
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254“…CsA treatment resulted in significant inhibition of PEDV-triggered apoptosis and suppressed PEDV replication. Furthermore, direct inhibition of AIF strongly impaired PEDV infection and virus-induced apoptosis. …”
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255por Pandurangi, Raghu S., Tomasetti, Marco, Verapazham, Sekar T., Paulmurugan, Ramasamy, Ma, Cynthia, Rajput, Sandeep, Anjanappa, Manjushree, Nakshatri, Harikrishna“…The drug design is based on a novel concept “A priori activation of apoptosis pathways of tumor technology (AAAPT) which is designed to activate specific cell death pathways and inhibit survival pathways simultaneously and selectively in cancer cells sparing normal cells. …”
Publicado 2021
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256por Ramadhani, Fatuma Jumapili, Kang, Seong Hee, Kawala, Remigius Ambrose, Chung, Byung Yeoup, Bai, Hyoung-Woo, Kang, Bo Sun“…Flow cytometry analysis evaluated apoptosis, mitochondrial membrane potential and cell cycle distribution. …”
Publicado 2021
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257“…Western blotting verified that the combination of sodium butyrate and cisplatin remarkably enhanced the levels of mitochondrial apoptosis-related pathway proteins. Conclusion: Sodium butyrate, a histone acetylation inhibitor produced by intestinal flora fermentation, combined with cisplatin enhanced the apoptosis of GC cells through the mitochondrial apoptosis-related pathway, which might be considered as a therapeutic option for GC.…”
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258por Taxis di Bordonia e Valnigra, Domitilla, Hassink, Gerco C., Levers, Marloes R., Frega, Monica, Hofmeijer, Jeannette, van Putten, Michel J. A. M., le Feber, Joost“…Hypoxia rapidly reduced network activity, but cultures showed limited apoptosis during the first 12 h. After 24 h, widespread apoptosis had occurred. …”
Publicado 2022
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260“…Furthermore we aimed to investigate which populations of mononuclear cells (lymphocytes, monocytes) undergo the apoptosis and to determine relations between apoptosis and serum levels of sFas/APO-1, ICE/caspase-1 or TNF-alpha. …”
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