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281“…An enhanced understanding of the role of p53 dysregulation and myofibroblast apoptosis may aid in future novel therapeutic and/or diagnostic strategies in organ fibrosis.…”
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282por Lee, Yong Gu, Yang, Nicholas, Chun, Inkook, Porazzi, Patrizia, Carturan, Alberto, Paruzzo, Luca, Sauter, Christopher Tor, Guruprasad, Puneeth, Pajarillo, Raymone, Ruella, Marco“…While T cell-based immunotherapies have multiple mechanisms of action, their ultimate goal is achieving apoptosis of cancer cells. Unsurprisingly, apoptosis evasion is a key feature of cancer biology. …”
Publicado 2023
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283“…The balance between apoptosis and autophagy regulates liver cell turnover and maintains intracellular homeostasis. …”
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285por Chen, Meng, Hu, Lei, Bao, Xuyuan, Ye, Kaiqin, Li, Yunjian, Zhang, Zhiyong, Kaufmann, Scott H., Xiao, Jun, Dai, Haiming“…The introduction of an R156E mutation in the BAK α4/α6/α7 groove not only decreases Eltro binding and Eltro-induced BAK activation in vitro but also diminishes Eltro-induced apoptosis. Thus, our data suggest that Eltro directly induces BAK activation and BAK-dependent apoptosis, providing a starting point for the future development of more potent and selective direct BAK activators.…”
Publicado 2023
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286“…Either the increased apoptosis of chondrocytes or the insufficient apoptosis of inflammatory macrophages and synovial fibroblasts are likely to underly this process. …”
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287por Moldovan, Cristian, Onaciu, Anca, Toma, Valentin, Munteanu, Raluca A., Gulei, Diana, Moldovan, Alin I., Stiufiuc, Gabriela F., Feder, Richard I., Cenariu, Diana, Iuga, Cristina A., Stiufiuc, Rares I.“…Defective regulation of apoptosis can trigger various diseases and disorders including cancer, neurological conditions, autoimmune diseases and developmental disorders. …”
Publicado 2023
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288“…A baculovirus gene, inhibitor of apoptosis (CpIAP), protected these cells from apoptosis. …”
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289“…In NIH3T3 murine fibroblasts, cadmium-induced apoptosis was inhibited by overexpression of the antiapoptotic protein Bcl-2. …”
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291“…Data from animal models suggest a role for Vascular Endothelial Growth Factor (VEGF) in the induction of apoptosis of structural cells in the lung. Other mediators of apoptosis, such as caspase-3 and ceramide, could be interesting targets to prevent apoptosis and the development of emphysema. …”
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292por MacKenzie, Simon, Montserrat, Nuria, Mas, Mario, Acerete, Laura, Tort, Lluis, Krasnov, Aleksei, Goetz, Frederick W, Planas, Josep V“…Interestingly, LPS administration in vivo induced apoptosis in follicular cells, an observation that correlated with changes in the expression of genes involved in apoptosis, as evidenced by microarray analysis. …”
Publicado 2006
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293“…Anti-TNF-alpha antibody blocked the apoptosis in both patients groups and healthy controls, suggesting that TNF-alpha acted as an inducer of apoptosis. …”
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294“…Apoptosis is an important event of the development of various organs. …”
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295por Castellino, Robert C, De Bortoli, Massimiliano, Lin, Linda L, Skapura, Darlene G, Rajan, Jessen A, Adesina, Adekunle M, Perlaky, Laszlo, Irwin, Meredith S, Kim, John YH“…Overexpression of TAp73 or ΔNp73 induced apoptosis under basal growth conditions in vitro and sensitized them to cell death in response to chemotherapeutic agents. …”
Publicado 2007
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296por Wyllie, A. H.“…Apoptosis is a mode of cell death with characteristic structural features. …”
Publicado 1993
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297“…Irradiation (2-10 Gy) induces apoptosis in a dose-dependent manner. Radiation-induced apoptosis occurs in a discrete wave 6-10 h after irradiation, and radiation-induced apoptosis is enhanced in cultures that are simultaneously deprived of bFGF. …”
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298Publicado 1994“…Apoptosis is the predominant form of cell death and occurs under a variety of physiological and pathological conditions. …”
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299por Madeo, Frank, Fröhlich, Eleonore, Ligr, Martin, Grey, Martin, Sigrist, Stephan J., Wolf, Dieter H., Fröhlich, Kai-Uwe“…Oxygen radicals are important components of metazoan apoptosis. We have found that apoptosis can be induced in the yeast Saccharomyces cerevisiae by depletion of glutathione or by low external doses of H(2)O(2). …”
Publicado 1999
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300“…Several modes of cell death are now recognized, including necrosis, apoptosis, and autophagy. Oftentimes the distinctions between these various modes may not be apparent, although the precise mode may be physiologically important. …”
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