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301“…Mitochondrial dysfunction and dysregulation of apoptosis are implicated in many diseases such as cancer and neurodegeneration. …”
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304Publicado 1994“…Fas is a 45-kD cell surface protein belonging to the tumor necrosis factor/nerve growth factor receptor family, and transduces the signal for apoptosis. The cytotoxic T lymphocyte (CTL) hybridoma, PC60-d10S requires the presence of Fas on target cells to induce cytolysis in target cells. …”
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305por Susin, Santos A., Daugas, Eric, Ravagnan, Luigi, Samejima, Kumiko, Zamzami, Naoufal, Loeffler, Markus, Costantini, Paola, Ferri, Karine F., Irinopoulou, Theano, Prévost, Marie-Christine, Brothers, Greg, Mak, Tak W., Penninger, Josef, Earnshaw, William C., Kroemer, Guido“…Apaf-1(−/−) or caspase-3(−/−) cells treated with a variety of apoptosis inducers manifest apoptosis-associated alterations including the translocation of apoptosis-inducing factor (AIF) from mitochondria to nuclei, large scale DNA fragmentation, and initial chromatin condensation (stage I). …”
Publicado 2000
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306por Kong, Young-Yun, Fischer, Klaus-Dieter, Bachmann, Martin F., Mariathasan, Sanjeev, Kozieradzki, Ivona, Nghiem, Mai P., Bouchard, Dennis, Bernstein, Alan, Ohashi, Pamela S., Penninger, Josef M.“…Activation of PKC with phorbol ester restored peptide-specific apoptosis in vav(−) (/−) thymocytes. Vav was found to bind constitutively to PKC-θ in thymocytes. …”
Publicado 1998
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309“…Long considered immunologically “bland,” apoptotic cells are now recognized as important modulators of immune responses. The role of apoptosis in immunological homeostasis has been inferred from several findings, for example, induction of tolerance after injection of apoptotic cells and the capacity of APCs like macrophages and DCs to induce and maintain tolerance after phagocytosis of dead cells. …”
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310“…Preferential localization of MT in the nuclei of NPC cells may possibly enhance radioresistance since radiotherapy is known to eradicate tumour cells by free radical-induced apoptosis. © 2000 Cancer Research Campaign…”
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311por Al-Saffar, N M S, Titley, J C, Robertson, D, Clarke, P A, Jackson, L E, Leach, M O, Ronen, S M“…Magnetic resonance spectroscopy is increasingly used as a non-invasive method to investigate apoptosis. Apoptosis was induced in Jurkat T-cells by Fas mAb. (1)H magnetic resonance spectra of live cells showed an increase in methylene signal as well as methylene/methyl ratio of fatty acid side chains at 5 and 24 h following induction of apoptosis. …”
Publicado 2002
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312“…Apoptosis was studied by flow cytometry, agarose gel electrophoresis and morphological analysis. …”
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313por Toiber, Debra, Berson, Amit, Greenberg, David, Melamed-Book, Naomi, Diamant, Sophia, Soreq, Hermona“…In cultured cell lines, N-AChE-S transfection activated the Tau kinase GSK3, induced Tau hyper-phosphorylation and caused apoptosis. N-AChE-S-induced cell death was suppressible by inhibiting GSK3 or caspases, by enforced overexpression of the anti-apoptotic Bcl2 proteins, or by AChE inhibition or silencing. …”
Publicado 2008
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315“…New cancer therapies are being developed that trigger tumour apoptosis and an in vivo method of apoptotic detection and early treatment response would be of great value. …”
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316por Bermudez, Yira, Erasso, Diana, Johnson, Nicole C, Alfonso, Michelle Y, Lowell, Nancy E, Kruk, Patricia A“…The ability of telomerase to suppress caspase-mediated apoptosis was p-jnk dependent since abrogation of jnk expression with jip abolished resistance to apoptosis. …”
Publicado 2006
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317“…The importance of apoptosis resides in the fact that several steps involved in the modulation of apoptosis are susceptible to therapeutic intervention. …”
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318“…The p53-inducible BH3-only protein PUMA is a key mediator of p53-dependent apoptosis, and PUMA has been shown to function by activating Bax and mitochondrial outer membrane permeabilization. …”
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319“…Stromal apoptosis was determined from the ratio between total and epithelial apoptosis. …”
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320por Litinsky, Ira, Golan, Itshak, Yaron, Michael, Yaron, Ilana, Caspi, Dan, Elkayam, Ori“…Following incubation, apoptosis was analyzed by two-dimensional flow cytometry (FACS) using annexin V/PI staining according to the manufacturer’s instructions. …”
Publicado 2009
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