“…Signaling via the intrinsic (mitochondrial) pathway of apoptosis represents one of the critical signal transduction cascades that control the regulation of cell death. …”
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“…THIS MULTIPRONGED EXPERIMENTAL APPROACH REVEALED THAT CISPLATIN ELICITS SIGNALING PATHWAYS THAT ARE FOR THE MOST PART “PRIVATE,” I.E., THAT MANIFEST LIMITED OVERLAP WITH THE MOLECULAR CASCADES IGNITED BY OTHER INDUCERS OF MITOCHONDRIAL APOPTOSIS, AND TRIGGERS APOPTOSIS MAINLY IN A TRANSCRIPTION-INDEPENDENT FASHION. …”
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“…Enhanced apoptosis is characteristic for chronic kidney disease (CKD). …”
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“…Here, we explore the link between nutrients, mitochondria and apoptosis with known and potential implications for age-related decline and metabolic syndromes.…”
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“…Autophagy and apoptosis are catabolic pathways essential for organismal homeostasis. …”
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“…Dependent on the type of stimulus, apoptosis can be propagated by extrinsic pathway or intrinsic pathway. …”
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“…Objective(s): Apoptosis is a tightly regulated process and plays a crucial role in autoimmune diseases. …”
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“…How cancer cells globally struggle with a chemotherapeutic insult before succumbing to apoptosis is largely unknown. Here we use an integrated systems-level examination of transcription, translation, and proteolysis to understand these events central to cancer treatment. …”
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“…As for the trait of ‘resistance to apoptosis’, the fact is that cancer has increased frequency of apoptosis. …”
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“…Here, our aim is to review their natural sources and their anticancer activity with specific emphasis on mechanism of actions, by which these compounds act on apoptosis pathways. Based on the literature and also on our previous results, alantolactone and isoalantolactone induce apoptosis by targeting multiple cellular signaling pathways that are frequently deregulated in cancers and suggest that their simultaneous targeting by these compounds could result in efficacious and selective killing of cancer cells. …”
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“…One of these coumarins is umbelliprenin, which has been implicated with induction of apoptosis in some cancer cell lines. In this study induction of apoptosis by umbelliprenin on Jurkat T-CLL and Raji B-CLL cell lines was studied. …”
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“…The loss of cardiomyocytes with aging occurs through apoptosis. Particularly, mitochondrial-mediated apoptotic pathway is the best characterized and believed critical in regulating apoptosis with aging, suggesting that mitochondria are very important sites of programmed cell death. …”
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“…BACKGROUND: Alterations to apoptosis are a common occurrence in human tumours. …”
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“…PURPOSE: To investigate the chemotherapeutic effect of quercetin against cancer cells, signaling pathway of apoptosis was explored in human pancreatic cells. METHODS: Various anticancer drugs including adriamycin, cisplatin, 5-fluorouracil (5-FU) and gemcitabine were used. …”
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“…T-2 toxin is known to induce apoptosis in mammalian cells. The mechanism of apoptosis induced by T-2 toxin has been proposed to be linked with oxidative stress and mitochondrial pathway. …”
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“…In this review we summarize the latest studies on lncRNAs and apoptosis with major attention to those performed in cancer cells and in healthy cells upon differentiation. …”
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“…Apoptosis, or programmed cell death, is an integral component of developmental biology, embryology, and anatomy. …”
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“…The objective was to determine apoptosis in sperm from high and low fertility bulls and its relationship with male fertility. …”
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