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42“…It has several binding partners and has been implicated in various functions ranging from stress response, control of cell proliferation, and inhibition/prevention of apoptosis. The activity of this protein involves different structural and functional mechanisms, and minor alterations in its expression level may lead to serious biological consequences, including neurodegeneration. …”
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44“…Abstract Apoptosis is an inborn process that has been preserved during evolution; it allows the cells to systematically inactivate, destroy and dispose of their own components thus leading to their death. …”
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45por Hong, Bum Kee, Kwon, Hyuck Moon, Byun, Ki Hyun, Kim, Dongsoo, Choi, Eui Young, Kang, Tae Soo, Kang, Seokmin, Chun, Kook Jin, Jang, Yangsoo, Kim, Hyun-Seung, Kim, Myeongkon“…For identification of apoptosis, immunohistochemistry with terminal deoxynucleotidyl transferase (TdT)-mediated dUTP-biotin nick end-labeling was performed, in addition, apoptosis was confirmed morphologically by confocal laser scanning microscopy with propidium iodide. …”
Publicado 2000
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46“…Hepatocyte apoptosis plays important roles in both the removal of external microorganisms and the occurrence and development of liver diseases. …”
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47por Zhong, Hua-Hua, Hu, Shao-Jie, Yu, Bo, Jiang, Sha-Sha, Zhang, Jin, Luo, Dan, Yang, Mei-Wen, Su, Wan-Ying, Shao, Ya-Lan, Deng, Hao-Lin, Hong, Fen-Fang, Yang, Shu-Long“…Aging is associated with high morbidity and a poor prognosis in patients with various liver diseases, including nonalcoholic fatty liver disease, hepatitis C and liver cancer, as well as with surgeries such as partial hepatectomy and liver transplantation. In addition, apoptosis increases with liver aging. Because apoptosis is involved in regeneration, fibrosis and cancer prevention during liver aging, and restoration of the appropriate level of apoptosis can alleviate the adverse effects of liver aging, it is important to understand the mechanisms underlying this process. …”
Publicado 2017
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48por Kvansakul, MarcEnlace del recurso
Publicado 2017
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49por Green, Douglas R.Enlace del recurso
Publicado 2001
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50por Abotaleb, Mariam, Samuel, Samson Mathews, Varghese, Elizabeth, Varghese, Sharon, Kubatka, Peter, Liskova, Alena, Büsselberg, Dietrich“…Targeting delayed/inhibited apoptosis is a major approach in cancer treatment and a highly active area of research. …”
Publicado 2018
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51“…In recent years, the essentials of developmental apoptosis have emerged. We hypothesize that apoptosis is predominantly required to balance cell proliferation. …”
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52por Lai, Yalan, Wang, Mingshu, Cheng, Anchun, Mao, Sai, Ou, Xumin, Yang, Qiao, Wu, Ying, Jia, Renyong, Liu, Mafeng, Zhu, Dekang, Chen, Shun, Zhang, Shaqiu, Zhao, Xin-Xin, Huang, Juan, Gao, Qun, Wang, Yin, Xu, Zhiwen, Chen, Zhengli, Zhu, Ling, Luo, Qihui, Liu, Yunya, Yu, Yanling, Zhang, Ling, Tian, Bin, Pan, Leichang, Rehman, Mujeeb Ur, Chen, Xiaoyue“…To resist viral infection, host organisms clear infected cells and viruses via apoptosis. However, throughout their long-term competition with host cells, enteroviruses have evolved a series of mechanisms to regulate the balance of apoptosis in order to replicate and proliferate. …”
Publicado 2020
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53“…Therefore, it is very important to study the apoptosis of eosinophils and their survival factors to understand how to develop new drugs based on the modulation of eosinophil apoptosis for the treatment of asthma and allergic diseases. …”
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54“…Apoptosis and clearance of dead cells is highly evolutionarily conserved from nematode to humans, which is crucial to the growth and development of multicellular organism. …”
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55“…Paradoxically, high-grade cancers are generally associated with high constitutive levels of apoptosis. In cancer, cell-autonomous apoptosis constitutes a common tumour suppressor mechanism, a property which is exploited in cancer therapy. …”
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56por Sorice, Maurizio“…Autophagy and apoptosis represent two fundamental pathophysiological mechanisms of cell fate regulation. …”
Publicado 2022
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57por Gu, Jia, Rauniyar, Sunil, Wang, Yan, Zhan, Wenjian, Ye, Chengkun, Ji, Shaogan, Liu, Guanzheng“…Chrysophanol promoted cell apoptosis via activating mitochondrial apoptosis pathway in glioma.…”
Publicado 2021
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58“…These results suggest that fish caspases are important elements in GGNNV-meditated apoptosis.…”
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59por Cheratta, Anees Rahman, Thayyullathil, Faisal, Pallichankandy, Siraj, Subburayan, Karthikeyan, Alakkal, Ameer, Galadari, Sehamuddin“…The tumor suppressor prostate apoptosis response-4 (Par-4) has recently turned ‘twenty-five’. …”
Publicado 2021
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60por Chen, Linlin, Ma, Yuming, Peng, Mengya, Chen, Wenbo, Xia, Huiqing, Zhao, Jingya, Zhang, Yake, Fan, Zhuo, Xing, Xiaoping, Li, Honglian“…Apoptosis, a type of programmed cell death, plays crucial roles in various physiological processes, from development to adaptive responses. …”
Publicado 2021
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