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  1. 117881
    por Gao, Wei, Zhang, Ying
    Publicado 2021
    “…RESULTS: The expression levels of MINCR were increased in a mouse model of LPS-induced ALI and small airway epithelial cells (SAECs). shMINCR resulted in increased cell viability and decreased apoptosis, which protected against LPS-induced cell damage. shMINCR can inhibit the formation of neutrophil extracellular traps, neutrophil numbers, myeloperoxidase activity, and the production of inflammatory cytokines IL-6, IL-1β, and TNF-α induced by LPS. …”
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    Depression of lncRNA MINCR antagonizes LPS-evoked acute injury and inflammatory response via miR-146b-5p and the TRAF6-NFkB signaling
  2. 117882
    “…Also, compound 6 (c) showed a marked elevation in the AnxV-FITC apoptotic HepG-2 cells percentage in both early and late phases increasing the total apoptosis percentage by 9.98-, and 10.81-fold, respectively, compared to the control. …”
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    Design and Synthesis of New Quinoxaline Derivatives as Potential Histone Deacetylase Inhibitors Targeting Hepatocellular Carcinoma: In Silico, In Vitro, and SAR Studies
  3. 117883
    “…ApoE(−/−) mice fed with a high‐fat diet showed decreased aortic valve orifice area, increased aortic transvalvular pressure difference and velocity, reduced left ventricular ejection fraction, decreased CD34 and vimentin, and increased caspase‐3, Runx2, and osteocalcin. The levels of apoptosis‐ and osteogenesis‐ related proteins were inhibited after EV treatment. …”
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    Telocytes‐derived extracellular vesicles alleviate aortic valve calcification by carrying miR‐30b
  4. 117884
    “…Although a wave of efforts had spurred to design novel therapeutic method of TNBC, unpredictable prognosis with lacking effective therapeutic targets along with the resistance to apoptosis seriously limited survival benefits. Ferroptosis is a non-apoptotic form of cell death that is induced by excessive lipid peroxidation, which provide an innovative way to combat cancer. …”
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    Simvastatin induced ferroptosis for triple-negative breast cancer therapy
  5. 117885
    “…This Ti-TCPP MOF was able to induce in vitro cellular apoptosis by directly destroying DNA and inducing S phase cell cycle arrest following US irradiation. …”
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    Intrinsic nucleus-targeted ultra-small metal–organic framework for the type I sonodynamic treatment of orthotopic pancreatic carcinoma
  6. 117886
    “…Furthermore, HLA class I-interactome profiling demonstrated altered interaction with key apoptosis and autophagy pathway proteins. In summary, our comprehensive multi-proteomic characterization in antigen presentation machinery provides potentially novel evidence of poor immune response in osimertinib-resistant lung adenocarcinoma. …”
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    Alterations in HLA Class I-Presented Immunopeptidome and Class I-Interactome upon Osimertinib Resistance in EGFR Mutant Lung Adenocarcinoma
  7. 117887
    “…We previously demonstrated that RBL2/p130 is a direct target of AKT and it is a key mediator of apoptosis associated with AKT inhibition. Here we demonstrated that RBL1/p107 levels are instead not directly modulated by AKT and discovered that RBL1/p107 levels are regulated by multiple pathways linked directly or indirectly to Ca(2+)-dependent signaling. …”
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    RBL1/p107 Expression Levels Are Modulated by Multiple Signaling Pathways
  8. 117888
    “…Herein, UBE2M depletion suppressed viability and proliferation and induced cell cycle arrest and apoptosis via cleavages of PARP and caspase 3 and upregulation of p53, Bax and PUMA in HepG2, Huh7 and Hep3B cells. …”
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    UBE2M Drives Hepatocellular Cancer Progression as a p53 Negative Regulator by Binding to MDM2 and Ribosomal Protein L11
  9. 117889
    “…The anti-cancer efficacy of Regorafenib was significantly reduced in 3D bioengineered cells when compared to 2D cultures and dose-dependently associated with cell apoptosis by cleaved PARP-1 activation and P-STAT3 inhibition. …”
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    Optimization and Validation of a Novel Three-Dimensional Co-Culture System in Decellularized Human Liver Scaffold for the Study of Liver Fibrosis and Cancer
  10. 117890
    “…Upregulated miRNAs were associated with decreased proliferation (miR-98-3p and miR-381-3p) and cellular adhesion (miR-29a-3p, miR-429-3p and miR3535), while downregulated miRNAs were connected to upregulation of apoptosis (Let-7d-5p and miR-130b-5p) and metabolism (miR-674-3p and miR-185-5p). …”
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    Integrated analysis of dysregulated microRNA and mRNA expression in intestinal epithelial cells following ethanol intoxication and burn injury
  11. 117891
    “…Lastly, guilt-by-association analysis showed that lncRNAs are correlated with apoptosis associated genes, suggesting potential roles for these lncRNAs in RGC survival. …”
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    Identification of long noncoding RNAs in injury-resilient and injury-susceptible mouse retinal ganglion cells
  12. 117892
    “…Twenty-four hours later, cells were subjected to various phenotypic and gene expression analyses for genes related to TFs, endoplasmic reticulum stress, apoptosis, cell proliferation, and differentiation markers. …”
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    NRF2-mediated signaling is a master regulator of transcription factors in bovine granulosa cells under oxidative stress condition
  13. 117893
    “…Based on the interaction and validation analysis, seven lncRNA GAS5-mediated ceRNA regulatory pathways were hypothesized to impact programmed cell death including seven for apoptosis, three for ferroptosis, and one for pyroptosis. …”
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    Novel lncRNA-miRNA-mRNA Competing Endogenous RNA Triple Networks Associated Programmed Cell Death in Heart Failure
  14. 117894
    “…SIMPLE SUMMARY: Epithelial–mesenchymal transition (EMT) is involved in metastasis formation, chemoresistance, apoptosis resistance, and acquisition of stem cell properties, making this process an attractive target in cancer. …”
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    GABARAPL1 Inhibits EMT Signaling through SMAD-Tageted Negative Feedback
  15. 117895
    por Krane, Markus, Dreßen, Martina, Santamaria, Gianluca, My, Ilaria, Schneider, Christine M., Dorn, Tatjana, Laue, Svenja, Mastantuono, Elisa, Berutti, Riccardo, Rawat, Hilansi, Gilsbach, Ralf, Schneider, Pedro, Lahm, Harald, Schwarz, Sascha, Doppler, Stefanie A., Paige, Sharon, Puluca, Nazan, Doll, Sophia, Neb, Irina, Brade, Thomas, Zhang, Zhong, Abou-Ajram, Claudia, Northoff, Bernd, Holdt, Lesca M., Sudhop, Stefanie, Sahara, Makoto, Goedel, Alexander, Dendorfer, Andreas, Tjong, Fleur V.Y., Rijlaarsdam, Maria E., Cleuziou, Julie, Lang, Nora, Kupatt, Christian, Bezzina, Connie, Lange, Rüdiger, Bowles, Neil E., Mann, Matthias, Gelb, Bruce D., Crotti, Lia, Hein, Lutz, Meitinger, Thomas, Wu, Sean, Sinnecker, Daniel, Gruber, Peter J., Laugwitz, Karl-Ludwig, Moretti, Alessandra
    Publicado 2021
    “…Premature cell cycle exit of ventricular cardiomyocytes from patients with HLHS prevented normal tissue responses to developmental signals for growth, leading to multinucleation/polyploidy, accumulation of DNA damage, and exacerbated apoptosis, all potential drivers of left ventricular hypoplasia in absence of hemodynamic cues. …”
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    Sequential Defects in Cardiac Lineage Commitment and Maturation Cause Hypoplastic Left Heart Syndrome
  16. 117896
    “…CONCLUSION: Imaging-guided DS-Ce6 photoactivation was able to in vivo detect inflammatory activity in atheroma as well as to simultaneously reduce both plaque burden and inflammation by harmonic contribution of apoptosis, autophagy, and lesional efferocytosis. These results suggest that macrophage targetable phototheranostic nanoagents will be a promising theranostic strategy for high-risk atheroma. …”
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    Targeted theranostic photoactivation on atherosclerosis
  17. 117897
    “…Imaging Hoechst-stained nuclei demonstrated apoptosis in a dose-dependent manner. BNPs exhibit better CT contrast enhancement ability compared to Omnipaque. …”
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    One Pot Synthesis of PEGylated Bimetallic Gold–Silver Nanoparticles for Imaging and Radiosensitization of Oral Cancers
  18. 117898
    “…Flow cytometry was used to test cell apoptosis rate. RNA pull-down and Dual luciferase reporter gene assay were performed to evaluate the crosstalk. …”
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    DLX6-AS1 activated by H3K4me1 enhanced secondary cisplatin resistance of lung squamous cell carcinoma through modulating miR-181a-5p/miR-382-5p/CELF1 axis
  19. 117899
    “…In the course of studies to define regulation of pyroptosis during Yersinia infection, we identified a line of Card19-deficient mice (Card19(lxcn)) whose macrophages were protected from cell lysis and showed reduced apoptosis and pyroptosis, yet had wild-type levels of caspase activation, IL-1 secretion, and GSDMD cleavage. …”
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    Genetic targeting of Card19 is linked to disrupted NINJ1 expression, impaired cell lysis, and increased susceptibility to Yersinia infection
  20. 117900
    “…The liver homogenate was precipitated using (NH(4))(2)SO(4) followed by separation on three columns and electrophoresis to identify the toxic molecule. Cell activity, apoptosis, proliferation, cell cycle, and expressions of proteins related to cell cycle were measured in hCMEC/D3 cells incubated with identified toxic molecules. …”
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    Hepatic Ischemia-Reperfusion Impairs Blood-Brain Barrier Partly Due to Release of Arginase From Injured Liver
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