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118381por Yang, Kaige, Xie, Yufang, Xue, Lele, Li, Fanping, Luo, Chenghua, Liang, Weihua, Zhang, Haijun, Li, Ya, Ren, Yilin, Zhao, Mengmeng, Wang, Weinan, Liu, Jia, Shen, Xihua, Zhou, Wenhu, Fei, Jing, Chen, Weigang, Gu, Wenyi, Wang, Lianghai, Li, Feng, Hu, Jianming“…METHODS: In order to study the role of M2-TAMs in ESCC chemoresistance, CCK-8, clone formation assay, flow cytometric apoptosis assay, qRT-PCR, western blotting, and serum-free sphere formation assays were used. …”
Publicado 2023
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118382por Zhang, Shi-Ran, Li, Jie, Chen, Jing-Xiang, Chen, Geng, Chen, Jun-Ying, Fu, Hang-Wei, Zhou, Bo“…Cellular proliferation was evaluated using MTT [3-(4,5)-dimethylthiahiazo (-z-y1)-2,5-di-phenytetrazoliumromide] and colony formation assays, wound healing and invasion assays were performed to study the invasion and migration ability of the cells, and flow cytometry assays were carried out to evaluate cell apoptosis. RESULTS: In the present study, we established a drug-resistant hepatoma cell line named HepG2/5-FU. …”
Publicado 2022
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118383por Shi, Fangfang, Xue, Rui, Xu, Hui, Mei, Feng, Bao, Xueyang, Dou, Jun, Zhao, Fengshu“…It has been reported that MUC1 influences cancer cell proliferation, apoptosis, invasion, and metastasis. The study aimed to explore the effect of MUC1 knockdown on the biological characteristics of the melanoma cell line B16F10 and evaluate whether MUC1 is an effective candidate target antigen for melanoma vaccine development. …”
Publicado 2022
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118384por Schmidt, Anke, da Silva Brito, Walison Augusto, Singer, Debora, Mühl, Melissa, Berner, Julia, Saadati, Fariba, Wolff, Christina, Miebach, Lea, Wende, Kristian, Bekeschus, Sander“…Using fluorescent NMP of several sizes (200 nm to 6 µm), efficient cellular uptake was observed, causing, however, only minor acute toxicity as metabolic activity and apoptosis data suggested, albeit changes in intracellular reactive species and thiol levels were observed. …”
Publicado 2023
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118385“…We found that exosome-related keywords included exosome, exosm, expression, extracellular vesicle, microRNA, microvesicle, and liquid biopsy, while disease- and pathological-related keywords included biomarker, microRNA, apoptosis, mechanism, systemic lupus erythematosus, EGFR, acute kidney injury, and chronic kidney disease. …”
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118386por Lacerda, Pammela A., Oenning, Luan C., Bellato, Guilherme Cuoghi, Lopes-Santos, Lucilene, Antunes, Natalícia de Jesus, Mariz, Bruno Augusto Linhares Almeida, Teixeira, Gabriela, Vasconcelos, Rafael, Simões, Gustavo Ferreira, de Souza, Ivani Aparecida, Pinto, Clóvis Antônio Lopes, Salo, Tuula, Coletta, Ricardo D., Augusto, Taize M., de Oliveira, Carine Ervolino, Cervigne, Nilva K.“…Results: PL treatment successfully impaired cell cycling and proliferation, migration, and invasion, enhanced apoptosis, and modulated macrophage polarization associated with the tumoral immune-inflammatory response of tongue cancer cell lines (TSCC). …”
Publicado 2023
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118387“…Multiple cell death modes including apoptosis, necroptosis, pyroptosis, and ferroptosis play a crucial role in the pathogenicity of inflammatory diseases. …”
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118388por Ju, Cheng, Ma, Yangguang, Zuo, Xiaoshuang, Wang, Xuankang, Song, Zhiwen, Zhang, Zhihao, Zhu, Zhijie, Li, Xin, Liang, Zhuowen, Ding, Tan, Hu, Xueyu, Wang, Zhe“…Bone-marrow-derived macrophages (BMDMs) were recruited to the injured area after SCI, and the M1 polarization is the key process for inducing inflammatory response and neuronal apoptosis. We previously showed that photobiomodulation (PBM) can inhibit the polarization of M1 phenotype of BMDMs and reduce inflammation, but the underlying mechanisms are unclear. …”
Publicado 2023
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118389“…The conclusions suggest that selenium yeast can effectively alleviate the oxidative damage by regulating different signaling pathways, improving the activity of antioxidant enzymes, reversing the content of inflammatory factors, regulating the protein expression of apoptosis-related genes, and reducing the accumulation of mycotoxins and heavy metals in the body.…”
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118390por Nitsch, Andreas, Sander, Caroline, Eggers, Benedikt, Weiss, Martin, Egger, Eva, Kramer, Franz-Josef, Erb, Holger H. H., Mustea, Alexander, Stope, Matthias B.“…The cell responses that were experimentally examined were cell growth (cell number determination, calculation of growth rate and doubling time), cell motility (scratch assay, invasiveness assay), membrane integrity (uptake of fluorescent dye, ATP release), and induction of apoptosis (TUNEL assay, caspase-3/7 assay, comet assay). …”
Publicado 2023
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118391por Ono, Motoki, Miyamoto, Tsutomu, Fuseya, Chiho, Asaka, Ryoichi, Ando, Hirofumi, Tanaka, Yasuhiro, Shinagawa, Manaka, Yokokawa, Yusuke, Takeuchi, Hodaka, Horiuchi, Akiko, Shiozawa, Tanri“…RESULTS: The addition of 6-MITC suppressed the proliferation of EMC cells (Ishikawa, HEC265, HEC108, KLE, and HEC1B) dose-dependently, but not HUVEC cells. 6-MITC (5 µM) enhanced the cisplatin sensitivity of EMC cells. 6-MITC induced apoptosis in a dose-dependent fashion in EMC cells other than HEC1B cells and was associated with increased expression of cleaved-caspase3 and decreased expression of BCL2. …”
Publicado 2023
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118392por Sullivan, Kevin M, Jiang, Xiuyun, Guha, Prajna, Lausted, Christopher, Carter, Jason A, Hsu, Cynthia, Labadie, Kevin P, Kohli, Karan, Kenerson, Heidi L, Daniel, Sara K, Yan, Xiaowei, Meng, Changting, Abbasi, Arezou, Chan, Marina, Seo, Y David, Park, James O, Crispe, Ian Nicholas, Yeung, Raymond S, Kim, Teresa S, Gujral, Taranjit S, Tian, Qiang, Katz, Steven C, Pillarisetty, Venu G“…In human CRLM slices, αIL-10 increased CEA-specific CAR-T cell activation and CAR-T cell-mediated cytotoxicity, with nearly 70% carcinoma cell apoptosis across multiple human tumours. Pretreatment with an IL-10 receptor blocking antibody also potentiated CAR-T function. …”
Publicado 2023
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118393“…Moreover, excessive miR-320 expression and excessive miR-204 expression can increase the apoptosis rate of myocardial cells. The above results indicated that the high expression of microRNA-320 and microRNA-204 can be a bad prognostic factor in patients with myocardial infarction, showing that medical data, machine learning and medical care strategies supporting IoMT can play a role in the treatment of myocardial infarction. …”
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118394por Weng, Danfeng, He, Long, Chen, Xiangna, Lin, Huangfeng, Ji, Daihan, Lu, Shuting, Ao, Lu, Wang, Shenglin“…RT-qPCR, cell viability and apoptosis assays were performed for in vitro validation. …”
Publicado 2023
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118395por Yusoh, Nur Aininie, Chia, Suet Lin, Saad, Norazalina, Ahmad, Haslina, Gill, Martin R.“…Mechanistic studies indicated that synergy is accompanied by increased double-strand break (DSB) DNA damage and reactive oxygen species (ROS) levels which subsequently lead to cell death via apoptosis. Moreover, the identified combination was successfully able to inhibit the growth of A549 lung cancer spheroids and acute zebrafish embryos toxicity studies revealed that this combination showed reduced toxicity compared to single-agent Ru-PIP.…”
Publicado 2023
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118396por Lellahi, Seyed Mohammad, Azeem, Waqas, Hua, Yaping, Gabriel, Benjamin, Paulsen Rye, Kristin, Reikvam, Håkon, Kalland, Karl-Henning“…In the present study, we found that extensive spontaneous apoptosis and cDC death in culture within 24hrs represent an additional challenge. …”
Publicado 2023
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118397por Tantikositruj, Chananphat, Gunawan, Asep, Uddin, Muhammad Jasim, Nuchchanart, Wirawan, Boonkaewwan, Chaiwat, Laenoi, Watchara, Kayan, Autchara“…Lipopolysaccharide-induced tumor necrosis factor-α factor (LITAF) is an essential transcription factor that regulates the immune system, apoptosis, and inflammatory cytokines. This study aimed to determine the hematological profile reflecting the immune response related to TLR2 and TLR4 and LITAF gene expression in Thai indigenous chickens. …”
Publicado 2022
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118398por Liao, Yan, Fu, Zeqin, Huang, Yinfu, Wu, Shiduo, Wang, Zhen, Ye, Shaotang, Zeng, Weijie, Zeng, Guifang, Li, Duanduan, Yang, Yulin, Pei, Ke, Yang, Jian, Hu, Zhiwei, Liang, Xiao, Hu, Junyuan, Liu, Muyun, Jin, Juan, Cai, Cheguo“…Pathologically, IL18-hUCMSC transplantation significantly enhanced the inhibition of inflammation, viral load, fibrosis, and cell apoptosis in acute lung injuries. Notably, IL18-hUCMSC treatment has a superior inhibitory effect on T-cell exudation and proinflammatory cytokine secretion in bronchoalveolar lavage fluid (BALF). …”
Publicado 2023
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118399por Zhao, Xiaotong, Xu, Murong, Tang, Ying, Xie, Dandan, Deng, Lili, Chen, Mingwei, Wang, Youmin“…The results of in vitro experiments showed that miR‐204‐3p could improve the proliferation and migration of HKC cells and reduce the proportion of apoptosis of HKC cells by targeted regulation of zinc finger protein Kruppel like factor 6 (KLF6) in high glucose environment. …”
Publicado 2022
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118400“…BACKGROUND: Somatic alterations in cancer cause dysregulation of signaling pathways that control cell-cycle progression, apoptosis, and cell growth. The effect of individual alterations in these pathways differs between individual tumors and tumor types. …”
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