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118621por Palsson, Sirus, Hickling, Timothy P, Bradshaw-Pierce, Erica L, Zager, Michael, Jooss, Karin, O’Brien, Peter J, Spilker, Mary E, Palsson, Bernhard O, Vicini, Paolo“…Cell recruitment, differentiation, replication, apoptosis and migration are described as appropriate for the different cell types. …”
Publicado 2013
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118622“…The interferon-induced protein with tetratricopeptide repeats (IFIT)1, IFIT2, IFIT3, interferon, α-inducible protein (IFI)6 (also known as G1P3), interferon regulatory factor 9 (IRF9, ISGF3), 2′–5′-oligoadenylate synthetase 1, 40/46 kDa (OAS1) and signal transducer and activator of transcription 1 (STAT1) genes all showed changes in expression following treatment with thymoquinone. The caspase 10, apoptosis-related cysteine peptidase (CASP10) gene was activated and the protein tyrosine phosphatase, receptor type, R (PTPRR) and myocyte enhancer factor 2C (MEF2C) genes were upregulated in the classical MAPK and p38 MAPK pathways. …”
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118623por Bernier, Annie, Cleret-Buhot, Aurélie, Zhang, Yuwei, Goulet, Jean-Philippe, Monteiro, Patricia, Gosselin, Annie, DaFonseca, Sandrina, Wacleche, Vanessa Sue, Jenabian, Mohammad-Ali, Routy, Jean-Pierre, Tremblay, Cécile, Ancuta, Petronela“…Th1Th17 cells expressed typical Th17 markers (IL-17A/F, IL-22, CCL20, RORC, IL-26, IL-23R, CCR6) and transcripts functionally linked to regulating cell trafficking (CEACAM1, MCAM), activation (CD28, CD40LG, TNFSF13B, TNFSF25, PTPN13, MAP3K4, LTB, CTSH), transcription (PPARγ, RUNX1, ATF5, ARNTL), apoptosis (FASLG), and HIV infection (CXCR6, FURIN). …”
Publicado 2013
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118624“…Significant up-regulation of proteins functionally related to oxidative stress and apoptosis suggests a major change of energy metabolism resulting in the state of severe brain cell “discomfort” or even death.…”
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118625por Xia, Wenle, Petricoin, Emanual F, Zhao, Sumin, Liu, Leihua, Osada, Takuya, Cheng, Qing, Wulfkuhle, Julia D, Gwin, William R, Yang, Xiaoyi, Gallagher, Rosa I, Bacus, Sarah, Lyerly, H Kim, Spector, Neil L“…The ability to overcome EGFR-mediated acquired therapeutic resistance to lapatinib was demonstrated through molecular knockdown of EGFR and treatment with the irreversible pan-HER TKI neratinib, which blocked HRG-dependent phosphorylation of HER3 and EGFR, resulting in apoptosis of resistant cells. In addition, whereas HRG reversed lapatinib-mediated antitumor effects in parental HER2(+) breast cancer cells, neratinib was comparatively resistant to the effects of HRG in parental cells. …”
Publicado 2013
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118626por Markosyan, Nune, Chen, Edward P, Evans, Rebecca A, Ndong, Victoire, Vonderheide, Robert H, Smyth, Emer M“…Tumors were analyzed, by real time PCR, immune-staining and flow cytometry, for proliferation, apoptosis, angiogenesis and immune microenvironment. …”
Publicado 2013
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118627“…Furthermore, the effect of GO and GE-rGO was examined using a series of assays, such as cell viability, membrane integrity, and reactive oxygen species generation, which are key molecules involved in apoptosis. The results obtained from cell viability and lactate dehydrogenase assay suggest that GO and GE-rGO cause dose-dependent toxicity in the cells. …”
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118628por Uhlig, Christopher, Silva, Pedro L, Ornellas, Débora, Santos, Raquel S, Miranda, Paulo J, Spieth, Peter M, Kiss, Thomas, Kasper, Michael, Wiedemann, Bärbel, Koch, Thea, Morales, Marcelo M, Pelosi, Paolo, de Abreu, Marcelo Gama, Rocco, Patricia RM“…INTRODUCTION: We investigated the effects of intravenous and intratracheal administration of salbutamol on lung morphology and function, expression of ion channels, aquaporin, and markers of inflammation, apoptosis, and alveolar epithelial/endothelial cell damage in experimental pulmonary (p) and extrapulmonary (exp) mild acute respiratory distress syndrome (ARDS). …”
Publicado 2014
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118629por Allison, S J, Knight, J R P, Granchi, C, Rani, R, Minutolo, F, Milner, J, Phillips, R M“…To summarise, this work indicates two distinct mechanisms by which suppressing LDH-A could potentially be used to kill cancer cells selectively, (i) through induction of apoptosis, irrespective of cancer cell p53 status and (ii) as a part of a combinatorial approach with redox-sensitive anticancer drugs via a novel p53/NAD(H)-dependent mechanism.…”
Publicado 2014
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118630por van Miltenburg, M H A M, van Nimwegen, M J, Tijdens, I, Lalai, R, Kuiper, R, Klarenbeek, S, Schouten, P C, de Vries, A, Jonkers, J, van de Water, B“…Focal adhesion kinase deletion reduced proliferative capacity of p53 null and p53(R270H) mammary epithelial cells but did not lead to increased apoptosis in vivo. Our data identify FAK as an important regulator in mammary epithelial cell proliferation in p53-mediated and p53(R270H)-induced mammary tumour development.…”
Publicado 2014
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118631“…The biological processes associated with these altered genes included, apoptosis/cell proliferation and metabolic pathways (predominant at 2 weeks); inflammation and cell signaling/activation (predominant at 3 weeks); and innate and adaptive immune responses (predominant at 4 weeks). …”
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118632por Huang, Bingqing, Qian, Juying, Ma, Jianying, Huang, Zheyong, Shen, Yunli, Chen, Xueying, Sun, Aijun, Ge, Junbo, Chen, Haozhu“…Significant increases in vascular endothelial growth factor (VEGF) and stromal cell-derived factor-1α (SDF-1α) expression, angiogenesis and MSC engraftment, as well as decreased cardiomyocyte apoptosis in peri-infarcted regions in the hearts of the HIF-1α + MSCs group were detected compared to the MSCs group and Control group. …”
Publicado 2014
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118633por HUA, YONG-QIANG, CHEN, ZHEN, MENG, ZHI-QIANG, CHEN, HAO, SHEN, JIAN-GANG, WANG, KUN, PENG, WANG, SHEN, YE-HUA, LIU, LU-MING“…Tumor weight inhibitory rate and tumor volume deflation were evaluated. The cell cycle and apoptosis were analyzed by flow cytometry, and reverse transcription polymerase chain reaction and western blot analysis were used to assess mRNA and protein levels. …”
Publicado 2014
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118634“…Nissl staining was used to assess striatal volume, cytoarchitecture, and apoptosis. Immunohistochemistry was used to localize and measure substance P (SP), leucine-enkephalin (LENK), tyrosine hydroxylase (TH), and calbindin D28 (CAL) immunoreactivities. …”
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118635“…To evaluate the role of LIF in the airways during RSV infection, animals were treated with neutralizing anti-LIF IgG, which enhanced RSV pathology observed with increased airspace protein content, apoptosis and airway hyperresponsiveness compared to control IgG treatment. …”
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118636por Li, Kesheng, Du, Huifen, Lian, Xiaowen, Yang, Suisheng, Chai, Dandan, Wang, Chunya, Yang, Rong, Chen, Xuezhong“…CONCLUSIONS: β2-M expression demonstrated a significant difference in the four breast cancer molecular subtypes, and may be related to apoptosis regulation in breast cancer.…”
Publicado 2014
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118637“…Moreover, miR-1, miR-10a, miR-125b, and miR-26a, which were implicated in modulating vascular smooth muscle cell functions such as proliferation, apoptosis and shift of phenotype, were also changed. …”
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118638“…Here, we showed that chaetocin suppressed viability and colony formation, and induced apoptosis of the murine hematopoietic cell line TonB210 with and without Bcr-Abl expression, and these effects were potentiated by BMSFs. …”
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118639por Zhu, Yi, Zhang, Jing-Jing, Xie, Kun-Ling, Tang, Jie, Liang, Wen-Biao, Zhu, Rong, Zhu, Yan, Wang, Bin, Tao, Jin-Qiu, Zhi, Xiao-Fei, Li, Zheng, Gao, Wen-Tao, Jiang, Kui-Rong, Miao, Yi, Xu, Ze-Kuan“…Based on stable forced-expressed pancreatic cancer PANC-1 cell model, functional studies show that MUC4/Y enhances malignant activity in vitro and in vivo, including proliferation under low-nutritional-pressure, resistance to apoptosis, motility, invasiveness, angiogenesis, and distant metastasis. …”
Publicado 2014
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118640por Wang, Dingyue, Xu, Shengyu, Lin, Yan, Fang, Zhengfeng, Che, Lianqiang, Xue, Bai, Wu, De“…BACKGROUND: Epidermal growth factor (EGF) is an important growth factor in regulation of cell proliferation, differentiation, survival and apoptosis. Studies showed that food-grade Lactococcus lactis (L. lactis) and NICE expression system have superior performance in exogenous protein expression. …”
Publicado 2014
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