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119321por Yu, Manli, Sun, Yangyong, Shan, Xinghua, Yang, Fan, Chu, Guojun, Chen, Qian, Han, Lin, Guo, Zhifu, Wang, Guokun“…Overexpression of miR-92a-2-5p attenuated cardiomyocyte oxidative stress injury, as demonstrated by increased glutathione level, and reduced reactive oxygen species accumulation, malondialdehyde and apoptosis levels. MAPK interacting serine/threonine kinase 2 (MKNK2) was verified as a novel target of miR-92a-2-5p. …”
Publicado 2022
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119322“…Functional enrichment analyses in the GO, KEGG and Reactome indicated the potential involvement of DEGs in endocrine metabolism, oxidative stress mechanisms, regulation of abnormal cell proliferation, apoptosis, DNA damage and repair. 2-OH-BDE85 is more cytotoxic in a dose-dependent manner than 2-OH-BDE47. …”
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119323por Şen, Uğur, Şirin, Emre, Önder, Hasan, Özyürek, Selçuk, Kolenda, Magdalena, Sitkowska, Beata“…The insulin-like growth factor family (IGFs) promotes the maturation of bovine oocytes and the expansion of cumulus cells and also inhibits apoptosis. This study was, therefore, designed to examine the effects of macromolecules (bovine serum albumin, BSA; fetal calf serum, FCS; and polyvinyl alcohol, PVA) on in vitro nuclear maturation, total cellular protein, glutathione peroxidase (GPx) enzyme activity, and the gene expression level of IGF1, IGF2, and their receptor in bovine oocytes. …”
Publicado 2022
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119324por Zhang, Weijing, Min, Lingjiang, Li, Yajing, Lang, Yaning, Hoque, S. A. Masudul, Adetunji, Adedeji Olufemi, Zhu, Zhendong“…Reduction of post-thaw goat sperm apoptosis in 2 mM proline treatment was also observed as the levels of Caspase3 and Caspase9 were decreased by the supplementation with 2 mM proline. …”
Publicado 2022
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119325por Lian, Hongxia, Zhang, Chuankai, Liu, Yifan, Li, Wenjing, Fu, Tong, Gao, Tengyun, Zhang, Liyang“…Transcriptome and metabolomic methods were used to obtain the molecular-based response of BRECs to different pH treatments; pH = 4.5 can significantly induce apoptosis of BRECs. The RNA-seq experiments revealed 1381 differently expressed genes (DEGs) in the control vs. …”
Publicado 2022
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119326por Xing, Ji, Chen, Wu, Chen, Kang, Zhu, Shaoming, Lin, Fangyou, Qi, Yucheng, Zhang, Yunlong, Han, Shangting, Rao, Ting, Ruan, Yuan, Zhao, Sheng, Yu, Weimin, Cheng, Fan“…Subsequently, in vitro, we knocked down TFAP2C in BCa cells and found that TFAP2C knockdown further increased cell cycle arrest and apoptosis caused by cisplatin. In addition, the inhibitory effect of cisplatin on BCa cell migration and invasion was enhanced by TFAP2C knockdown. …”
Publicado 2022
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119327por Roliano, Gabriela Gonçalves, Azambuja, Juliana Hofstätter, Brunetto, Veronica Toniazzo, Butterfield, Hannah Elizabeth, Kalil, Antonio Nochi, Braganhol, Elizandra“…The P1 family purinoceptors A1, A2A, and A2B were positively associated with tumor progression, but A2B resulted in increased cancer cell apoptosis. The P2 family purinoceptors P2X5, P2X7, P2Y(2), P2Y(6), and P2Y(12) were factors primarily associated with promoting CRC progression. …”
Publicado 2022
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119328por Sanada, Yohei, Ikuta, Yasunari, Ding, Chenyang, Shinohara, Masahiro, Yimiti, Dilimulati, Ishitobi, Hiroyuki, Nagira, Keita, Lee, Minjung, Akimoto, Takayuki, Shibata, Sachi, Ishikawa, Masakazu, Nakasa, Tomoyuki, Matsubara, Kiminori, Lotz, Martin K., Adachi, Nobuo, Miyaki, Shigeru“…Immunohistochemistry was performed for OA-related factors, senescence markers, and apoptosis. RESULTS: Starting at 14 weeks of age, SAMP8 exhibited mild OA-like changes such as proteoglycan loss and cartilage fibrillation. …”
Publicado 2022
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119329por Yuan, Hang, Chen, Bingchen, Chai, Rui, Gong, Wenjing, Wan, Ziang, Zheng, Boan, Hu, Xinye, Guo, Yang, Gao, Shan, Dai, Qiaoqiong, Yu, Peng, Tu, Shiliang“…Cell viability was tested using the cell counting kit-8 assay, and flow cytometry was used to assess cell apoptosis. Cell invasion and migration were evaluated using the transwell assay. …”
Publicado 2022
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119330por Cheng, Jung-Chien, Han, Xiaoyu, Meng, Qingxue, Guo, Yanjie, Liu, Boqun, Song, Tinglin, Jia, Yuanyuan, Fang, Lanlan, Sun, Ying-Pu“…HB-EGF has been shown to regulate luteal function by preventing cell apoptosis. Steroidogenesis is the primary function of the human corpus luteum. …”
Publicado 2022
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119331por Bai, Bing, Liu, Yezhou, Abudukerimu, Azierguli, Tian, Tingting, Liang, Meiting, Li, Rui, Sun, Yuping“…Additionally, the DEGs were found to regulate inflammatory responses and were associated with apoptosis. TNF, IL-1β, NLRP3, CXCL8, PTGS2, NFE2L2, CASP8, and CD274 were identified as key hub genes in the PPI network, and a miRNA-mRNA network was constructed, which had 16 edges. …”
Publicado 2022
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119332por Elgendy, Salwa A., Baloza, Samar H., Mohammed, Lina Abdelhady, Nasr, Hend Elsayed, Osama El-Shaer, Noha, Ghamry, Heba I., Althobaiti, Saed A., Shukry, Mustafa, Soliman, Mohamed Mohamed, Elnoury, Heba A.“…In conclusion, WGO ameliorated ethanol-induced hepatic and renal dysfunction at the biochemical, molecular and cellular levels by regulating some mechanisms that controls oxidative stress, apoptosis, inflammation and anti-apoptotic pathways.…”
Publicado 2022
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119333por Myo Min, Kay K., Rojas-Canales, Darling, Penko, Daniella, DeNichilo, Mark, Cockshell, Michaelia P., Ffrench, Charlie B., Thompson, Emma J., Asplund, Olof, Drogemuller, Christopher J., Prasad, Rashmi B., Groop, Leif, Grey, Shane T., Thomas, Helen E., Loudovaris, Thomas, Kay, Thomas W., Mahoney, My G., Jessup, Claire F., Coates, P. Toby, Bonder, Claudine S.“…Dsg2(lo/lo) mice also exhibited a reduction in blood vessel barrier integrity, an increased incidence of streptozotocin-induced diabetes, and islets isolated from Dsg2(lo/lo) mice were more susceptible to cytokine-induced β-cell apoptosis. Following transplantation into diabetic mice, islets isolated from Dsg2(lo/lo) mice were less effective than their wildtype counterparts at curing diabetes. …”
Publicado 2022
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119334por Chamusco, Karen C., Milazzo, May N., Bhan, Kanchan S., Kamps, Terry L., Smith, Prestina, Durojaiye, Modupeoluwa, Moreira, Cristina D., Gallo, Maria, Chase, Christine D.“…RESULTS: Terminal deoxynucleotidyl transferase dUTP nick end labeling revealed both chromatin and nuclear fragmentation in the collapsed CMS-S pollen, demonstrating a programmed cell death (PCD) event sharing morphological features with mitochondria-signaled apoptosis in animals. Maize plants expressing mitochondria-targeted green fluorescent protein (GFP) demonstrated dynamic changes in mitochondrial morphology and association with actin filaments through the course of N-cytoplasm pollen development, whereas mitochondrial targeting of GFP was lost and actin filaments were disorganized in developing CMS-S pollen. …”
Publicado 2022
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119335“…CONCLUSION: Both of PJ and PCG downregulated miR-21 expression and triggered apoptosis. However, PJ was more effective than pure PCG in alleviating the hepatic antioxidant defense state and the inflammatory status. …”
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119336por Yoshino, Satoshi, Horiguchi, Emi Ishida Kazuhiko, Matsumoto, Shunichi, Yamada, Eijiro, Yamada, Masanobu“…In comprehensive gene analysis using Microarray analysis of mRNA extracted from mice islet, the gene expression changes related insulin secretion and apoptosis have been revealed in MLL heterozygous mice. …”
Publicado 2022
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119337por Caffarelli, Carla, Pitinca, Maria Dea Tomai, Refaie, Antonella A, Giglio, Elisa, Lombardi, Fiorella Anna, Gonnelli, Stefano“…This paradox could be explained from compromise bone microarchitecture that induce abnormal bone cell function and matrix structure, with increased osteoblast apoptosis, diminished osteoblast differentiation, and enhanced osteoclast-mediated bone resorption.1 In this context, a non-invasive method for assessing the bone density and quality on the axial reference sites (lumbar spine and proximal femur) called Radiofrequency Echographic Multi Spectrometry (REMS), has been introduced and clinically validated. …”
Publicado 2022
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119338“…Importantly, this reduced growth rate was not due to increased apoptosis. As cell cycle exit is associated with differentiation, we next sought to determine the fate of SH-SY5Y cells cultured in B-27. …”
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119339por Borneman, Rebecca M., Gavin, Elaine, Musiyenko, Alla, Richter, Wito, Lee, Kevin J., Crossman, David K., Andrews, Joel F., Wilhite, Annelise M., McClellan, Steven, Aragon, Ileana, Ward, Antonio B., Chen, Xi, Keeton, Adam B., Berry, Kristy, Piazza, Gary A., Scalici, Jennifer M., da Silva, Luciana Madeira“…Using small molecule inhibitors, Pf-2545920 and a novel NSAID-derived PDE10A inhibitor, MCI-030, we show that PDE10A inhibition leads to decreased ovarian cancer cell growth and induces cell cycle arrest and apoptosis. We demonstrate these pro-apoptotic properties occur through PKA and PKG signaling by using specific inhibitors to block their activity. …”
Publicado 2022
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119340por Reinhardt, Kristin, Stückrath, Kathrin, Hartung, Carolin, Kaufhold, Sandy, Uleer, Christoph, Hanf, Volker, Lantzsch, Tillmann, Peschel, Susanne, John, Jutta, Pöhler, Marleen, Bauer, Marcus, Bürrig, Friedrich Karl, Weigert, Edith, Buchmann, Jörg, Kantelhardt, Eva Johanna, Thomssen, Christoph, Vetter, Martina“…PURPOSE: Phosphatidylinositide-3-kinase (PI3K) regulates proliferation and apoptosis; somatic PIK3CA-mutations may activate these processes. …”
Publicado 2022
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