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  1. 119361
    “…In liver, BA treatment, both alone and together with tolvaptan, increased mitochondrial biogenesis while inhibiting apoptosis. We conclude that BA and ACLY inhibition inhibited cyst growth in vitro, and BA decreased ADPKD severity in vivo. …”
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    Beneficial effects of bempedoic acid treatment in polycystic kidney disease cells and mice
  2. 119362
    “…Finally, we reveal a possible contributing role of necroptosis and apoptosis in enhancing ileum and colon epithelium development, respectively. …”
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    Integrated multi-omics of the gastrointestinal microbiome and ruminant host reveals metabolic adaptation underlying early life development
  3. 119363
    “…The treatment of the in vitro co‐culture system of Z24(−/−) FAPs and WT MPCs with the senolytic drug fisetin led to increased apoptosis of Z24(−/−) FAPs (14.5‐fold; n > =6, P < 0.001) and rescued the impaired function of MPCs by increasing the number of MHC‐positive myotubes for 3.1 times (n > =6, P < 0.001). …”
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    Reduction of senescent fibro‐adipogenic progenitors in progeria‐aged muscle by senolytics rescues the function of muscle stem cells
  4. 119364
    por Terzi, Funda, Ciftci, Mustafa Kemal
    Publicado 2022
    “…The in situ TUNEL method showed that the tacrolimus increased apoptosis while the silymarin decreased it. TOC levels increased statistically in Tac groups compared to silymarin-treated groups (P < 0.05). …”
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    Protective effect of silymarin on tacrolimus-induced kidney and liver toxicity
  5. 119365
    por Samaras, Charilaos, Kyriazopoulou, Evdoxia, Poulakou, Garyfallia, Reiner, Eran, Kosmidou, Maria, Karanika, Ioanna, Petrakis, Vasileios, Adamis, George, Gatselis, Nikolaos K., Fragkou, Archontoula, Rapti, Aggeliki, Taddei, Eleonora, Kalomenidis, Ioannis, Chrysos, George, Bertoli, Giulia, Kainis, Ilias, Alexiou, Zoi, Castelli, Francesco, Saverio Serino, Francesco, Bakakos, Petros, Nicastri, Emanuele, Tzavara, Vassiliki, Kostis, Evangelos, Dagna, Lorenzo, Koukidou, Sofia, Tzatzagou, Glykeria, Chini, Maria, Bassetti, Matteo, Trakatelli, Christina, Tsoukalas, George, Selmi, Carlo, Samarkos, Michael, Pyrpasopoulou, Athina, Masgala, Aikaterini, Antonakis, Emmanouil, Argyraki, Aikaterini, Akinosoglou, Karolina, Sympardi, Styliani, Panagopoulos, Periklis, Milionis, Haralampos, Metallidis, Simeon, Syrigos, Konstantinos N., Angel, Alon, Dalekos, George N., Netea, Mihai G., Giamarellos-Bourboulis, Evangelos J.
    Publicado 2023
    “…We investigated the performance of C-reactive protein (CRP), interferon gamma-induced protein-10 (IP-10) and TNF-related apoptosis-inducing ligand (TRAIL) for predicting SRF or death in COVID-19. …”
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    Interferon gamma-induced protein 10 (IP-10) for the early prognosis of the risk for severe respiratory failure and death in COVID-19 pneumonia
  6. 119366
    “…The effects of IL-1β on 5-FU response was evaluated by assessing cell viability (MTS assay) and apoptosis (flow cytometry analysis) following treatment with 5-FU alone or in combination with the cytokine. …”
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    IL-1β enhances cell viability and decreases 5-FU sensitivity in novel colon cancer cell lines derived from African American patients
  7. 119367
    “…Transwell assays and flow cytometry were performed to assess cell migration and invasion and apoptosis, respectively. Moreover, factors associated with overall survival were analysed by using the Cox proportional hazards model. …”
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    CREB1 regulates KPNA2 by inhibiting mir-495-3p transcription to control melanoma progression: The role of the CREB1/miR-495-3p/KPNA2 axis in melanoma progression
  8. 119368
    “…METHODS: The cytotoxic effect of chaetoglobosin E and cisplatin on esophageal cancer KYSE-30, KYSE-150, and TE-1 cells was detected using cell viability or colony formation assays. The cell cycle, apoptosis, autophagy, invasion, and metastasis were assayed by flow cytometry or western blot. …”
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    Chaetoglobosin E inhibits tumor growth and promotes the anti-tumor efficacy of cytotoxic drugs in esophageal squamous cell carcinoma by targeting PLK1
  9. 119369
    “…In addition, niosome-loaded SeNPs can upregulate the expression level of Bax, cas3, and cas9 apoptosis genes while the expression of the Bcl2 gene is down-regulated in all studied cell lines, significantly. …”
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    Niosomes-loaded selenium nanoparticles as a new approach for enhanced antibacterial, anti-biofilm, and anticancer activities
  10. 119370
    “…We previously demonstrated that mycobacterial infection upregulated tumor necrosis factor-like weak inducer of apoptosis (TWEAK) to promote autophagy and mycobacterial autophagosome maturation through activation of AMP-activated protein kinase (AMPK). …”
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    TWEAK-Fn14 Axis Induces Calcium-Associated Autophagy and Cell Death To Control Mycobacterial Survival in Macrophages
  11. 119371
    “…CONCLUSIONS: In mice, the vein wall responded to deep vein thrombosis induction with elevation of RIPK3 without showing markers of necroptosis and apoptosis. Studies using genetic or pharmacological inhibition of RIPK3 suggest that this cell death mediator may not have a major role in the acute phase of venous thrombogenesis. …”
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    Investigating the role of receptor interacting protein kinase 3 in venous thrombosis
  12. 119372
    “…In addition, the treatment of nanoparticles doped with Ce and Yb induced apoptosis in HCT-116 cells. In summary, our results demonstrated that the synthesized nanoparticles showed antifungal, antibacterial and anticancer potential, which could be considered for potential pharmaceutical applications. …”
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    In Vitro Antimicrobial and Anticancer Peculiarities of Ytterbium and Cerium Co-Doped Zinc Oxide Nanoparticles
  13. 119373
    “…However, upon the exposure to (sz,hc)-cfDNA, the size of the subpopulation with apoptosis signs (high DNA damage degree, high NOX4 and low NRF2 and BRCA1 levels) also increased. …”
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    In Vitro Analysis of Biological Activity of Circulating Cell-Free DNA Isolated from Blood Plasma of Schizophrenic Patients and Healthy Controls—Part 2: Adaptive Response
  14. 119374
    “…Subsequently, this combination approach upregulated p53-mediated MGMT inhibition, leading to apoptosis. Furthermore, we observed the cotreatment also enabled triggering of cell senescence and decreased expression of stem cell biomarkers. …”
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    BMX, a specific HDAC8 inhibitor, with TMZ for advanced CRC therapy: a novel synergic effect to elicit p53-, β-catenin- and MGMT-dependent apoptotic cell death
  15. 119375
    “…Charged particle irradiation induced more G0-/G1- or G2-/M-phase arrest, more expression of γ-H2AX, more apoptosis, and lower motility and/or migration ability than photon irradiation. …”
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    Does particle radiation have superior radiobiological advantages for prostate cancer cells? A systematic review of in vitro studies
  16. 119376
    “…Brain histopathology, including hematoxylin staining, Nissl staining and Terminal dUTP nick-end labeling (TUNEL) staining, was performed to evaluate the surviving cells and apoptotic cells. Apoptosis-related proteins after ROSC for 72 h were analyzed by western blot. …”
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    Establishment of a nonshockable rhythm cardiac arrest model caused by asphyxia
  17. 119377
    “…Transcriptome analysis displayed that osmoregulation-, DNA-repair- and apoptosis-related terms or pathways were enriched in GO and KEGG analysis. …”
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    Transcriptome analysis reveals the high temperature induced damage is a significant factor affecting the osmotic function of gill tissue in Siberian sturgeon (Acipenser baerii)
  18. 119378
    “…The expression of IL-1β and Sox9 in macrophages and melanomacrophages suggests the role of the liver in regulation of both innate and adaptive immunity, cell proliferation and apoptosis, in addition to stem cell maintenance.…”
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    Structural and immunohistochemical analysis of the cellular compositions of the liver of molly fish (Poecilia sphenops), focusing on its immune role
  19. 119379
    “…The expression levels of Toll-like receptor 4 (TLR4), nuclear factor kappa B (NF-κB), gasdermin-D (GSDMD), nucleotide-binding oligomerization domain-like receptor protein 3 (NLRP3), apoptosis-associated speck-like protein containing a C-terminal caspase recruitment domain (ASC), Caspase-1, and IL-1β in lung tissues were detected by immunohistochemistry, Western blotting, or quantitative polymerase chain reaction (qPCR). …”
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    Halotherapy relieves chronic obstructive pulmonary disease by alleviating NLRP3 inflammasome-mediated pyroptosis
  20. 119380
    “…Furthermore, NCX4040 treatment induced TNF-dependent pathways which further increases oxidative stress in ovarian tumor cells, resulting in enhanced NCX4040-mediated cell death from apoptosis and/or ferroptosis. ABSTRACT: The nitric oxide donor, NCX4040 is a non-steroidal anti-inflammatory-NO donor and has been shown to be extremely cytotoxic to a number of human tumors, including ovarian tumors cells. …”
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    Gene Expression Profiling Elucidates Cellular Responses to NCX4040 in Human Ovarian Tumor Cells: Implications in the Mechanisms of Action of NCX4040
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