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  1. 119541
    “…Results support a mechanistic basis for the importance of SOD2 in proliferation and apoptosis of mesothelial cells and its potential use as a biomarker of early responses to mesotheliomagenic minerals.…”
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    Mechanisms of oxidative stress and alterations in gene expression by Libby six-mix in human mesothelial cells
  2. 119542
    “…Monoclonals that we were able to develop from tumor specific proteins derived from colon and pancreas cancer were found capable of targeting those tumors to induce apoptosis. We were also able to define immunogenic membrane proteins from lung (squamous and adenoCa) as well as prostate neoplasms. …”
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    The Therapeutic Value of Monoclonal Antibodies Directed Against Immunogenic Tumor Glycoproteins
  3. 119543
    “…Studies have shown that miRNAs play a critical role in human cancer and they can influence the level of cell proliferation and apoptosis by modulating gene expression. Currently, methods for the detection and measurement of miRNA expression include small and moderate-throughput technologies, such as standard quantitative PCR and microarray based analysis. …”
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    Quantitative miRNA Expression Analysis Using Fluidigm Microfluidics Dynamic Arrays
  4. 119544
    “…BACKGROUND: The tumor suppressor gene p53 is involved in multiple cellular pathways including apoptosis, transcriptional control, and cell cycle regulation. …”
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    MDM2 SNP309, gene-gene interaction, and tumor susceptibility: an updated meta-analysis
  5. 119545
    “…The loss of cell viability induced by SHP2 silencing could not be explained by a significant increase in apoptosis alone as demonstrated by terminal deoxyribonucleotidyl transferase-mediated nick-end labelling and propidium iodide staining. …”
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    Src homology domain-containing phosphatase 2 suppresses cellular senescence in glioblastoma
  6. 119546
    “…Galectin-3 is multifunctional protein, which is involved in regulation of cell growth, cell adhesion, cell proliferation, angiogenesis and apoptosis. Cyclin D1 together with other cyclin plays an important role in cell cycle control. …”
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    Galectin-3 and cyclin D1 expression in non-small cell lung cancer
  7. 119547
    “…Moreover, 1,25(OH)D has anti-proliferative and pro-differentiation effects in human melanoma cells. 1,25(OH)D has been shown to induce apoptosis in human melanoma cell lines and has an inhibitory effect on the spreading of melanoma cells in vitro. …”
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    Why vitamin D for cancer patients?
  8. 119548
    “…BACKGROUND: Insulin-like growth factors (IGFs) and their binding proteins (BPs) regulate cell differentiation, proliferation and apoptosis, and may have a role in the aetiology of various cancers. …”
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    Concentrations of IGF-I and IGFBP-3 and pancreatic cancer risk in the European Prospective Investigation into Cancer and Nutrition
  9. 119549
    “…The A431 parental cells acutely treated with Ctx rapidly activated FGFR3 and their concomitant exposure to Ctx and PD173074 resulted in synergistic apoptosis. CONCLUSION: Cross-suppression of AREG/EREG expression may explain the tight co-expression of AREG and EREG, as well as their tendency to be more highly expressed than other EGFR ligands to determine Ctx efficacy. …”
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    Cross-suppression of EGFR ligands amphiregulin and epiregulin and de-repression of FGFR3 signalling contribute to cetuximab resistance in wild-type KRAS tumour cells
  10. 119550
    por Bis, Joshua C., DeCarli, Charles, Smith, Albert Vernon, van der Lijn, Fedde, Crivello, Fabrice, Fornage, Myriam, Debette, Stephanie, Shulman, Joshua M., Schmidt, Helena, Srikanth, Velandai, Schuur, Maaike, Yu, Lei, Choi, Seung-Hoan, Sigurdsson, Sigurdur, Verhaaren, Benjamin F.J., DeStefano, Anita L., Lambert, Jean-Charles, Jack, Clifford R., Struchalin, Maksim, Stankovich, Jim, Ibrahim-Verbaas, Carla A., Fleischman, Debra, Zijdenbos, Alex, den Heijer, Tom, Mazoyer, Bernard, Coker, Laura H., Enzinger, Christian, Danoy, Patrick, Amin, Najaf, Arfanakis, Konstantinos, van Buchem, Mark A., de Bruijn, Renée F.A.G., Beiser, Alexa, Dufouil, Carole, Huang, Juebin, Cavalieri, Margherita, Thomson, Russell, Niessen, Wiro J., Chibnik, Lori B., Gislason, Gauti K., Hofman, Albert, Pikula, Aleksandra, Amouyel, Philippe, Freeman, Kevin B., Phan, Thanh G., Oostra, Ben A., Stein, Jason L., Medland, Sarah E., Vasquez, Alejandro Arias, Hibar, Derrek P., Wright, Margaret J., Franke, Barbara, Martin, Nicholas G., Thompson, Paul M., Nalls, Michael A., Uitterlinden, Andre G., Au, Rhoda, Elbaz, Alexis, Beare, Richard J., van Swieten, John C., Lopez, Oscar, Harris, Tamara B., Chouraki, Vincent, Breteler, Monique M.B., De Jager, Philip L., Becker, James T., Vernooij, Meike W., Knopman, David, Fazekas, Franz, Wolf, Philip A., van der Lugt, Aad, Gudnason, Vilmundur, Longstreth, W.T., Brown, Mathew A., Bennett, David A., van Duijn, Cornelia M., Mosley, Thomas H., Schmidt, Reinhold, Tzourio, Christophe, Launer, Lenore J., Ikram, M. Arfan, Seshadri, Sudha
    Publicado 2012
    “…These associations implicate genes related to apoptosis (HRK), development (WIF1), oxidative stress (MSR3B), ubiquitination (FBXW8), enzymes targeted by new diabetes medications (DPP4), and neuronal migration (ASTN2), indicating novel genetic influences that influence hippocampal size and possibly the risk of cognitive decline and dementia.…”
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    Common variants at 12q14 and 12q24 are associated with hippocampal volume
  11. 119551
    “…These systems provide insights regarding the emergence of key systems at different points in eukaryotic evolution, such as ADP ribosylation, interaction of myosin VI with cargo proteins, mediation of apoptosis, hyphal heteroincompatibility, hedgehog signaling, arthropod toxins, cell-cell interaction molecules like teneurins and different signaling messengers. …”
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    Polymorphic toxin systems: Comprehensive characterization of trafficking modes, processing, mechanisms of action, immunity and ecology using comparative genomics
  12. 119552
    “…Peripheral blood mononuclear cells (PBMC) were stimulated by rIL-21 (100 ng/ml) in the presence or absence of anti-CD40 and/or anti-IgM, and changes of IL-21R, activation-associated surface markers (CD25, CD69 and CD40), the proliferation, apoptosis and differentiation of B cells were analyzed by flow cytometry. …”
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    A regulatory effect of IL-21 on T follicular helper-like cell and B cell in rheumatoid arthritis
  13. 119553
    “…The mRNA expression level of tumor protein T53 and transforming growth factor beta receptor 1 were found significantly reduced in critically ill patients, whereas the expression of Janus kinase 2, caspase 3 apoptosis-related cysteine peptidase, interleukin 10, and myxovirus resistance 1 were extremely increased in critically ill patients. …”
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    Microarray analysis of MicroRNA expression in peripheral blood mononuclear cells of critically ill patients with influenza A (H1N1)
  14. 119554
    “…We demonstrate that differentially expressed mature miRNAs target cell differentiation and apoptosis related biological processes, indicating that they might represent, with acceptable accuracy, the genetic context from which they derive. …”
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    High-throughput sequencing of small RNA transcriptomes reveals critical biological features targeted by microRNAs in cell models used for squamous cell cancer research
  15. 119555
    “…These included PI3K/AKT pathway proteins, those regulating the cell cycle, apoptosis, transcription, and other signaling pathways including steroid hormone signaling. …”
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    A functional proteogenomic analysis of endometrioid and clear cell carcinomas using reverse phase protein array and mutation analysis: protein expression is histotype-specific and loss of ARID1A/BAF250a is associated with AKT phosphorylation
  16. 119556
    “…Apo2 ligand (Apo2L)/tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) treatment (TR) is known to induce autophagy. …”
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    Autophagic flux determines cell death and survival in response to Apo2L/TRAIL (dulanermin)
  17. 119557
    “…Inversely, PEDF–DTX-5 mg/kg and PEDF–CTX-10 mg/kg delayed the most CL1 tumor growth (15, 11 and 5 days for PEDF–DTX-5 mg/kg, PEDF–CTX-10 mg/kg and single treatments, respectively) with elevated apoptosis and serum thrombospondin-1 as possible mechanism and marker, respectively. …”
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    Pigment epithelium-derived factor expression prolongs survival and enhances the cytotoxicity of low-dose chemotherapy in castration-refractory prostate cancer
  18. 119558
    “…ADORA3 is instead involved in the induction of p53-mediated apoptosis in lung cancer cell lines. Since in our model p53 is inactivated, ADORA3 does not negatively affect tumor growth but remains expressed on tumor cells. …”
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    Characterization of a genetic mouse model of lung cancer: a promise to identify Non-Small Cell Lung Cancer therapeutic targets and biomarkers
  19. 119559
    “…The treatment of HNSCC with a specific inhibitor of c-Src, initially resulted in reduced Stat3 and Stat5 activation and subsequently an arrest of cell proliferation and increased apoptosis. However, the inhibition of c-Src only caused a persistent inhibition of Stat5, whereas the inhibition of Stat3 was only transient. …”
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    Resistance of Cancer Cells to Targeted Therapies Through the Activation of Compensating Signaling Loops
  20. 119560
    “…Moreover, this mitotic delay enhanced chromosomal abnormalities and apoptosis. CONCLUSIONS: We have identified NUP214, a member of the massive nuclear pore complex, as a novel miR-133b target. …”
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    Inhibition of nucleoporin member Nup214 expression by miR-133b perturbs mitotic timing and leads to cell death
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