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  1. 119921
    por Mok, Helen, Al-Jumaily, Ahmed, Lu, Jun
    Publicado 2022
    “…RESEARCH IN CONTEXT:   What is already known about this subject: The noncoding gene PVT1 was highly expressed in mice and patients with DN; PVT1 promotes DN through increasing extracellular matrix (ECM) accumulation in vitro; Silencing of PVT1 attenuated secretion of ECM proteins and delayed podocyte apoptosis in vitro. What is the key question: Does the inhibition of the noncoding gene PVT1 in a diabetic nephropathy mouse model either prevent or delay the onset of diabetic nephropathy? …”
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    Plasmacytoma Variant Translocation 1 (PVT1) Gene as a Potential Novel Target for the Treatment of Diabetic Nephropathy
  2. 119922
    “…The KEGG analysis also revealed that such mRNAs were significantly enriched in the ECM-receptor interaction, sphingolipid metabolism, apoptosis, PI3K-Akt signaling pathway, and AMPK signaling pathway. …”
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    Construction and Comprehensive Analysis of miRNAs and Target mRNAs in Longissimus dorsi Muscle of Queshan Black and Large White Pigs
  3. 119923
    “…Among these differentially expressed genes (DEGs), KLF9, AMPK, FOXO3, PTX3, GADD45, PTPN1, CASP7, MAPK4, HSPA12A, and JAK-STAT were probably associated with the effects of stress on skeletal muscle proteins and involved in biological process such as cellular response to corticosteroid stimulus, endoplasmic reticulum stress, insulin resistance, DNA repair, apoptosis, MAPK cascade and regulation of proteolysis. …”
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    RNA-Seq exploration of the influence of stress on meat quality in Spanish goats
  4. 119924
    “…The expression levels of markers involved in apoptosis and alanine aminotransferase (ALT) were compared by means of western blotting. …”
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    Obese mammary tumour-bearing mice are highly sensitive to doxorubicin-induced hepatotoxicity
  5. 119925
    “…JAM3 suppresses cell proliferation, colony formation, migration and invasion and induces G1/S arrest and apoptosis in EC. Further study demonstrated that JAM3 suppressed EC cells and xenograft tumor growth by inhibiting Wnt/β-catenin signaling. …”
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    Epigenetic silencing of JAM3 promotes esophageal cancer development by activating Wnt signaling
  6. 119926
    “…Histological injury and apoptosis were assessed by two pathologists. RESULTS: After severe ARDS modeling, pigs in ARDS, LTV and APRV groups experienced significant hypoxemia and reduced lung static compliance (C(stat)). …”
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    Effects of airway pressure release ventilation on multi-organ injuries in severe acute respiratory distress syndrome pig models
  7. 119927
    “…Hsa-miR-21-5p had the highest number of predicted target genes and was associated with several pathways, including insulin signaling and apoptosis. 34.1% (14/41) of the differentially expressed miRNAs also targeted mitochondrial genes, and 80.5% (33/41) of them targeted nuclear genes involved in the mitochondrial metabolism. …”
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    Global miRNA expression reveals novel nuclear and mitochondrial interactions in Type 1 diabetes mellitus
  8. 119928
    “…CONCLUSIONS: Msx2 maybe inhibit the apoptosis of goose dermal fibroblasts and promotes their proliferation. …”
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    Regulation of feather follicle development and Msx2 gene SNP degradation in Hungarian white goose
  9. 119929
    “…GO and KEGG analysis show that the differentially expressed genes were mainly involved in MAPK pathway, Toll-like receptor pathway, NF-κB pathway and apoptosis. KEGG disease analysis reveals that they were closely involved in immune system diseases, cardiovascular disease, cancers, inflammatory bowel disease (IBD) et al. …”
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    Identification and characterization of non-coding RNA networks in infected macrophages revealing the pathogenesis of F. nucleatum-associated diseases
  10. 119930
    “…RESULTS: Drug library screening revealed MHC-I upregulation by inhibitor of apoptosis inhibitor (IAPi)- and HDACi drug classes. …”
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    Epigenetic modulation of neuroblastoma enhances T cell and NK cell immunogenicity by inducing a tumor-cell lineage switch
  11. 119931
    “…Detection of SARS-CoV-2 RNA and viral proteins in liver non-parenchymal cells suggests that while the most extended primary viral cytotoxic effect occurs in the lung, viral components are present in other organs too, as in the liver. The necrosis/apoptosis and endothelial damage associated with viral infection in COVID-19 suggest that those patients who survive more severe COVID-19 may face prolonged liver repair and accordingly should be followed regularly in the post-COVID period.…”
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    Liver alterations and detection of SARS-CoV-2 RNA and proteins in COVID-19 autopsies
  12. 119932
    “…Growing evidence suggests that targeting apoptosis-associated speck-like protein containing a CARD (ASC), the oligomerization of which is the key event for the assembly of inflammasome, may be another promising therapeutic strategy. …”
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    Directly targeting ASC by lonidamine alleviates inflammasome-driven diseases
  13. 119933
    “…SAMHD1 silencing synergized with radiation to activate ssDNA-STING-IFN-I pathway, inhibit proliferation, promote apoptosis and regulate cell cycle. SAMHD1 silencing cooperated with radiotherapy to inhibit tumor growth and increase CD86(+)MHC-II(high) M1 proportion and CD8(+) T cell infiltration in vivo. …”
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    SAMHD1 silencing cooperates with radiotherapy to enhance anti-tumor immunity through IFI16-STING pathway in lung adenocarcinoma
  14. 119934
    “…However, at ≤ 5-µM dose SF in combination with MU inhibited HAS3/HA synthesis, growth of RCC cells and endothelial-RCC co-cultures, and induced apoptosis. The combination inhibited motility/invasion and an HA-signaling-related invasive-signature. …”
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    Targeting hyaluronic acid synthase-3 (HAS3) for the treatment of advanced renal cell carcinoma
  15. 119935
    “…After ingesting by tumor cells via CD44 mediated endocytosis, the acidic lysosomal condition will further trigger the protonation of TA molecules, finally leading to the Fe(3+) release of nanoprobe, and inducing a hybrid ferroptosis/apoptosis of tumor cells through peroxidase activity and glutathione depletion. …”
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    Dual-stimuli responsive smart nanoprobe for precise diagnosis and synergistic multi-modalities therapy of superficial squamous cell carcinoma
  16. 119936
    “…RESULTS: We identified the impairment of intracellular SH-containing biomolecules, which are major cellular antioxidants, as a putative MIE, with subsequent KEs defined as ROS accumulation, mitochondrial damage, DNA damage and lipid peroxidation, apoptosis, reduced production of reproductive hormones and reduced quality of sperm. …”
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    Putative adverse outcome pathways for silver nanoparticle toxicity on mammalian male reproductive system: a literature review
  17. 119937
    “…Validated gene targets of the cf-miRNAs varying with the menstrual cycle were enriched within female reproductive tissues and are primarily involved in cell proliferation and apoptosis. LARGE SCALE DATA: All relevant data are available from the Mendeley database: LEGER, Bertrand (2022), ‘MiRNA and menstrual cycle’, Mendeley Data, V1, doi: 10.17632/2br3zp79m3.1. …”
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    The effect of the menstrual cycle on the circulating microRNA pool in human plasma: a pilot study
  18. 119938
    por Nam, Hyung-song, Capecchi, Mario R.
    Publicado 2023
    “…In the old Lrig1 germline knock-out mice, increased proliferation was observed compared to wildtype littermates without concomitant increase in apoptosis. CONCLUSIONS: Once set aside during embryogenesis, the Lrig1-lineage stem cells remain largely quiescent during postnatal and juvenile development until activation in adult age. …”
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    Lrig1 expression identifies quiescent stem cells in the ventricular-subventricular zone from postnatal development to adulthood and limits their persistent hyperproliferation
  19. 119939
    “…Furthermore, PRL treatment may reduce outgrowth degeneration by increasing resistance to apoptosis during trophoblast migration. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12958-023-01062-0.…”
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    Post-warming culture of human vitrified blastocysts with prolactin improves trophoblast outgrowth
  20. 119940
    “…Cell proliferation, apoptosis, and tumorigenesis in nude mice were examined to investigate the functions of circZKSaa. …”
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    A novel polypeptide encoded by the circular RNA ZKSCAN1 suppresses HCC via degradation of mTOR
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