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  1. 120021
    “…Overall, suicidality may be underlined, at least in part, by biological mechanisms related to stress, inflammation and apoptosis.…”
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    Discovery and validation of blood biomarkers for suicidality
  2. 120022
    “…Doses of 0.5–5 Gy were applied and endpoints such as cell cycle progression (measured by flow cytometry), apoptosis (microscopic analysis of cell nucleus morphology), induction of chromosome aberrations (mFISH analysis), presence of pluripotency markers Oct3/4 and SOX2 (western blotting) and differentiation capacity by means of an embryoid body formation assay were analyzed up to 17 days post-irradiation. …”
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    The effect of X-rays and C-ions on pluripotent embryonic stem cells
  3. 120023
    “…Si-FZD7 OC cells showed reduced cell proliferation with an increase in the G0/G1 sub-population, with no effect on apoptosis. The cells also displayed a distinctive morphologic change by colony compaction to become more epithelial-like and polarised with smaller internuclear distances and increased z-axis height. …”
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    FZD7 drives in vitro aggressiveness in Stem-A subtype of ovarian cancer via regulation of non-canonical Wnt/PCP pathway
  4. 120024
    por Galluzzi, L, Bravo-San Pedro, J M, Vitale, I, Aaronson, S A, Abrams, J M, Adam, D, Alnemri, E S, Altucci, L, Andrews, D, Annicchiarico-Petruzzelli, M, Baehrecke, E H, Bazan, N G, Bertrand, M J, Bianchi, K, Blagosklonny, M V, Blomgren, K, Borner, C, Bredesen, D E, Brenner, C, Campanella, M, Candi, E, Cecconi, F, Chan, F K, Chandel, N S, Cheng, E H, Chipuk, J E, Cidlowski, J A, Ciechanover, A, Dawson, T M, Dawson, V L, De Laurenzi, V, De Maria, R, Debatin, K-M, Di Daniele, N, Dixit, V M, Dynlacht, B D, El-Deiry, W S, Fimia, G M, Flavell, R A, Fulda, S, Garrido, C, Gougeon, M-L, Green, D R, Gronemeyer, H, Hajnoczky, G, Hardwick, J M, Hengartner, M O, Ichijo, H, Joseph, B, Jost, P J, Kaufmann, T, Kepp, O, Klionsky, D J, Knight, R A, Kumar, S, Lemasters, J J, Levine, B, Linkermann, A, Lipton, S A, Lockshin, R A, López-Otín, C, Lugli, E, Madeo, F, Malorni, W, Marine, J-C, Martin, S J, Martinou, J-C, Medema, J P, Meier, P, Melino, S, Mizushima, N, Moll, U, Muñoz-Pinedo, C, Nuñez, G, Oberst, A, Panaretakis, T, Penninger, J M, Peter, M E, Piacentini, M, Pinton, P, Prehn, J H, Puthalakath, H, Rabinovich, G A, Ravichandran, K S, Rizzuto, R, Rodrigues, C M, Rubinsztein, D C, Rudel, T, Shi, Y, Simon, H-U, Stockwell, B R, Szabadkai, G, Tait, S W, Tang, H L, Tavernarakis, N, Tsujimoto, Y, Vanden Berghe, T, Vandenabeele, P, Villunger, A, Wagner, E F, Walczak, H, White, E, Wood, W G, Yuan, J, Zakeri, Z, Zhivotovsky, B, Melino, G, Kroemer, G
    Publicado 2015
    “…Nonetheless, efficiently inhibiting the processes that are commonly thought to cause RCD, such as the activation of executioner caspases in the course of apoptosis, does not exert true cytoprotective effects in the mammalian system, but simply alters the kinetics of cellular demise as it shifts its morphologic and biochemical correlates. …”
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    Essential versus accessory aspects of cell death: recommendations of the NCCD 2015
  5. 120025
    “…BACKGROUND: Posttranslational protein modifications are known to modulate key biological processes like proliferation and apoptosis. Accumulating evidence shows that ST6GAL1, an enzyme that catalyzes the transfer of sialic acid onto galactose-containing substrates, is aberrantly expressed in various cancers and may affect cell motility and invasion. …”
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    Epigenetic inactivation of ST6GAL1 in human bladder cancer
  6. 120026
    “…BACKGROUND: A20 is a dual inhibitor of NF-κB activation and apoptosis in the tumor necrosis factor receptor 1 signaling pathway, and both are related to tumorigenesis. …”
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    Overexpression of MALT1-A20-NF-κB in adult B-cell acute lymphoblastic leukemia
  7. 120027
    “…Via specific mRNA complementary pairing of target genes, miRNAs are able to regulate the expression of mRNA levels or inhibit protein translation following transcription. miRNA expression has a time- and space specificity, and it is involved in cell proliferation and differentiation, apoptosis, development, tumor metastasis occurrence and other biological processes. miR-26b is an miRNA of 22 nt and is important in the regulation of cellular processes. …”
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    Expression of microRNA-26b and identification of its target gene EphA2 in pituitary tissues in Yanbian cattle
  8. 120028
    “…BACKGROUND: BCL-xL is an anti-apoptotic BCL-2 family protein that inhibits apoptosis and is overexpressed in many cancers. We have reported that acquired resistance to the BCL-2 inhibitor ABT-199 (venetoclax) is associated with increased BCL-xL expression. …”
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    miR-377-dependent BCL-xL regulation drives chemotherapeutic resistance in B-cell lymphoid malignancies
  9. 120029
    “…Terminal deoxynucleotidyl transferase-mediated dUTP nick-end labeling (TUNEL) was performed to detect photoreceptor apoptosis. RESULTS: The microanatomy of the retinal sections revealed disorganization of the outer nuclear layer (ONL) in the B6N and Grk1(−/−)(;B6N) mice and a significant decrease in the thickness of the ONL in the 3-month-old Grk1(−/−)(;B6N) mice. …”
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    The retinal phenotype of Grk1(−/−) is compromised by a Crb1(rd8) mutation
  10. 120030
    “…STUDY DESIGN, SIZE, DURATION: The effects of fetal sex and maternal cigarette smoking on the second trimester (11–21 weeks of gestation) human fetal AGD were studied, along with measurement of testosterone and testicular transcripts associated with apoptosis and proliferation. PARTICIPANTS/MATERIALS, SETTING METHODS: AGD, measured from the centre of the anus to the posterior/caudal root of penis/clitoris (AGD(app)) was determined in 56 female and 70 male morphologically normal fetuses. …”
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    Human anogenital distance: an update on fetal smoke-exposure and integration of the perinatal literature on sex differences
  11. 120031
    “…Then, the effect of Nrf2 alone and in combination with TGF-β1 on cell growth and survival was investigated by cell counting, Ki67 staining and apoptosis assays. The underlying cell signaling was investigated by western blotting. …”
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    The anti-oxidative transcription factor Nuclear factor E2 related factor-2 (Nrf2) counteracts TGF-β1 mediated growth inhibition of pancreatic ductal epithelial cells -Nrf2 as determinant of pro-tumorigenic functions of TGF-β1
  12. 120032
    “…In our ongoing work we are developing an improved miRiaD web interface that will facilitate complex queries about microRNA-disease relationships, such as “In what diseases does microRNA regulation of apoptosis play a role?” or “Is there overlap in the sets of genes targeted by microRNAs in different types of dementia?”.” …”
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    miRiaD: A Text Mining Tool for Detecting Associations of microRNAs with Diseases
  13. 120033
    “…Further study revealed that the knockdown of HuR significantly increased the apoptosis of ASM cells and dampened TGF-β1, Col-I and α-SMA expression. …”
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    A HuR/TGF-β1 feedback circuit regulates airway remodeling in airway smooth muscle cells
  14. 120034
    “…Colony formation, growth, apoptosis, migration, matrix adhesion, traction force analyses and polarization of tumor cells were studied in vitro. …”
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    ITIH5 mediates epigenetic reprogramming of breast cancer cells
  15. 120035
    “…In addition, this population expresses different ILC markers: CD132, CD90, CD161, α4 integrin, c-Kit, CRTH2, AhR, and IL-23R. IL-3 prevents apoptosis and increases their NFIL3, TOX, and PLZF expression. …”
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    A Human Lin(−) CD123(+) CD127(low) Population Endowed with ILC Features and Migratory Capabilities Contributes to Immunopathological Hallmarks of Psoriasis
  16. 120036
    “…Upon additional drug response testing, dual PI3K (Phosphatidylinositol 3-Kinase)/mTOR and topoisomerase 2A inhibitors displayed up to >100-fold increased activity in hereditary c.1380delA CDH1 gastric cancer cells inducing apoptosis most effectively in cells with deficient CDH1 function. …”
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    Transcriptomic profiling and quantitative high-throughput (qHTS) drug screening of CDH1 deficient hereditary diffuse gastric cancer (HDGC) cells identify treatment leads for familial gastric cancer
  17. 120037
    “…Gene ontological analysis indicated these target genes were mainly involved in cell proliferation, differentiation, growth, apoptosis, and ion transport, and 14 miRNAs, including miR-143, miR-10a, and let-7 were screened as candidate miRNAs in Hu sheep hair follicle growth and development. …”
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    Screening candidate microRNAs (miRNAs) in different lambskin hair follicles in Hu sheep
  18. 120038
    “…Cell survival studies were done by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay after 48 h treatment with hesperetin, and cell apoptosis was determined by flow cytometry. The protein levels of activated signaling molecules (pSTAT3, pAKT, and pERK1/2) analyzed by immunoprecipitation technique. …”
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    Biological Effects of Hesperetin on Interleukin-6/Phosphorylated Signal Transducer and Activator of Transcription 3 Pathway Signaling in Prostate Cancer PC3 Cells
  19. 120039
    “…FZD10 silencing caused significant sensitization towards cisplatin treatment in survival assays and apoptosis assays. CONCLUSIONS: By applying genome-wide integrated methylome analysis on extreme chemoresponsive HGSOC patients, we identified novel clinically relevant, epigenetically-regulated markers of platinum-sensitivity in HGSOC patients. …”
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    Methylome analysis of extreme chemoresponsive patients identifies novel markers of platinum sensitivity in high-grade serous ovarian cancer
  20. 120040
    “…Further investigation showed that overexpression of lnc-IGFBP4–1 significantly promoted LC cell proliferation in vitro and in vivo, while downregulation of endogenous lnc-IGFBP4–1 could inhibited cell proliferation and induce apoptosis. Moreover, we found lnc-IGFBP4–1 could influences ATP production levels and expression of enzymes including HK2, PDK1 and LDHA, in addition, decline in both ATP production and these enzymes in response to 2-DG and 2-DG-combined Rho123, respectively, was observed in lnc-IGFBP4–1-overespressing LC cells, indicative of an enhanced aerobic glycolysis rate. …”
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    Overexpression of lncRNA IGFBP4–1 reprograms energy metabolism to promote lung cancer progression
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