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141Publicado 1994“…As a consequence of this inhibition of cell contact the colon carcinoma cells rapidly underwent apoptosis. Investigations of the apoptotic pathway involved suggested an induction mechanism since the onset of apoptosis in the contact- inhibited cells showed specific increased synthesis of 68- and 72-kD proteins. …”
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142“…Apoptosis or programmed cell death plays a pivotal role in embryonic development and maintenance of homeostasis. …”
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143por Herker, Eva, Jungwirth, Helmut, Lehmann, Katharina A., Maldener, Corinna, Fröhlich, Kai-Uwe, Wissing, Silke, Büttner, Sabrina, Fehr, Markus, Sigrist, Stephan, Madeo, Frank“…Here, we demonstrate that chronologically aged yeast cultures die exhibiting typical markers of apoptosis, accumulate oxygen radicals, and show caspase activation. …”
Publicado 2004
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144por Wissing, Silke, Ludovico, Paula, Herker, Eva, Büttner, Sabrina, Engelhardt, Silvia M., Decker, Thorsten, Link, Alexander, Proksch, Astrid, Rodrigues, Fernando, Corte-Real, Manuela, Fröhlich, Kai-Uwe, Manns, Joachim, Candé, Céline, Sigrist, Stephan J., Kroemer, Guido, Madeo, Frank“…Apoptosis-inducing factor (AIF), a key regulator of cell death, is essential for normal mammalian development and participates in pathological apoptosis. …”
Publicado 2004
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147“…BACKGROUND: Apoptosis, one of the main types of programmed cell death, is regulated and performed by a complex protein network. …”
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149“…Asymmetric cell division and apoptosis (programmed cell death) are two fundamental processes that are important for the development and function of multicellular organisms. …”
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150“…We documented that apoptosis occurs among viable (proliferating) tumour cells in all adenocarcinoma cases examined in this study. …”
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151por Baleriola, Jimena, García-Feijoo, Julián, Martínez-de-la-Casa, José M., Fernández-Cruz, Arturo, de la Rosa, Enrique J., Fernández-Durango, Raquel“…We established and validated an in toto method to perform TdT-mediated dUTP nick end labeling to study apoptosis in human trabecular meshwork tissue obtained during trabeculectomy in glaucoma patients. …”
Publicado 2008
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152“…The magnitude of oxidative stress determines the degree of lysosomal destabilization and, consequently, whether arrested growth, reparative autophagy, apoptosis, or necrosis will follow. Heterophagy is the first step in the process by which immunocompetent cells modify antigens and produce antibodies, while exocytosis of lysosomal enzymes may promote tumor invasion, angiogenesis, and metastasis. …”
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153“…Apoptosis, or programmed cell death, is a highly conserved cellular suicide mechanism. …”
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155por Shi, Xin, LeCapitaine, Nicole J, Rudner, Xiaowen L, Ruan, Sanbao, Shellito, Judd E“…In splenic lymphocytes, apoptosis was observed early at 1 week after inoculation and then declined. …”
Publicado 2009
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156“…It has been directly demonstrated that eosinophil apoptosis is delayed in allergic inflammatory sites, and that this mechanism contributes to the expansion of eosinophil numbers within tissues. …”
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157“…While there is a clear connection between apoptosis and autophagy, the mechanisms that regulate the interaction have been difficult to identify. …”
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158“…Fas is a cell surface protein that can mediate apoptosis and belongs to the tumor necrosis factor (TNF) receptor family. …”
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159por Wong, Rebecca SY“…Apoptosis is an ordered and orchestrated cellular process that occurs in physiological and pathological conditions. …”
Publicado 2011
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160“…Mouse mutants that have helped to define the mammalian apoptosis execution machinery, including animals lacking Apaf-1, caspase-3 and caspase-9, are also described. …”
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