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  1. 1
    “…To determine whether HIV diversity impacts the ARCHITECT HIV Combo Ag/Ab (HIV Combo) or RealTime HIV-1 (RT) assays, a set of N = 199 HIV clinical specimens from Cameroon, Senegal, Saudi Arabia, and Thailand were sequenced and tested in both assays. …”
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  2. 2
    “…We evaluated the use of DBS whole blood samples in the modified Abbott ARCHITECT anti-HCV assay, comparing assay performance against the standard assay run using DBS and venous plasma samples. 144 HCV positive and 104 HCV negative matched venous plasma and whole blood specimens were selected from a retrospective study with convenience sampling in Cameroon. …”
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  3. 3
    “…Samples were screened for HDV antibodies on the Abbott ARCHITECT instrument and for HDV RNA on the Abbott m2000 instrument by research assays. …”
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  4. 4
    “…All specimens were screened for HCV using the Abbott RealTime HCV viral load assay and positive specimens with remaining volume were also screened for HPgV‐2 antibodies on the Abbott ARCHITECT instrument, followed by molecular characterization. …”
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  5. 5
    “…To evaluate the clinical utility of HBsAg isoforms, we developed novel prototype assays on the ARCHITECT automated serology platform that specifically detects total-HBsAg (T-HBsAg), large (L-HBsAg), and middle (M-HBsAg) products of the S gene to determine the isoform composition of human specimens from acute and chronic HBV infection and during long-term nucleos(t)ide analog therapy. …”
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  6. 6
    “…Prototype molecular (RNA) and serologic (IgG) assays were developed for high-throughput testing on the Abbott m2000 and ARCHITECT systems, respectively. RNA detection was achieved through amplification of a ribozyme region target, with a limit of detection of 5 IU/ml. …”
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  7. 7
    por Peluso, Michael J., Takahashi, Saki, Hakim, Jill, Kelly, J. Daniel, Torres, Leonel, Iyer, Nikita S., Turcios, Keirstinne, Janson, Owen, Munter, Sadie E., Thanh, Cassandra, Nixon, Christopher C., Hoh, Rebecca, Tai, Viva, Fehrman, Emily A., Hernandez, Yanel, Spinelli, Matthew A., Gandhi, Monica, Palafox, Mary-Ann, Vallari, Ana, Rodgers, Mary A., Prostko, John, Hackett, John, Trinh, Lan, Wrin, Terri, Petroplolous, Christos J., Chiu, Charles Y., Norris, Philip J., DiGermanio, Clara, Stone, Mars, Busch, Michael P., Elledge, Susanna K., Zhou, Xin X., Wells, James A., Shu, Albert, Kurtz, Theodore W., Pak, John E., Wu, Wesley, Burbelo, Peter D., Cohen, Jeffrey I., Rutishauser, Rachel L., Martin, Jeffrey N., Deeks, Steven G., Henrich, Timothy J., Rodriguez-Barraquer, Isabel, Greenhouse, Bryan
    Publicado 2021
    “…Variations in sensitivity and durability were particularly dramatic for individuals with mild infection, who had consistently lower antibody titers and represent the majority of the infected population, with sensitivities often differing substantially from reported test characteristics (e.g., amongst commercial assays, sensitivity at 6 months ranged from 33% for ARCHITECT IgG to 98% for VITROS Total Ig). Thus, the ability to detect previous infection by SARS-CoV-2 is highly dependent on the severity of the initial infection, timing relative to infection, and the assay used. …”
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