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  1. 57741
    “…The resulting matches are refined into simple multi-domain architectures using a recently developed in-house algorithm, DomainFinder 3 (available at: ftp://ftp.biochem.ucl.ac.uk/pub/gene3d_data/DomainFinder3/). …”
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    Gene3D: merging structure and function for a Thousand genomes
  2. 57742
    “…Four thousand three hundred and seventy-four of these CASGPs form 1759 complex gene architectures. We found that ∼35% (6347/18160) of RefSeq genes are overlapped with the antisense transcripts. …”
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    Integrative analysis of the human cis-antisense gene pairs, miRNAs and their transcription regulation patterns
  3. 57743
    por Jostins, Luke, Jaeger, Johannes
    Publicado 2010
    “…Secondly, it has the potential to be used as part of a hierarchical evolutionary algorithm, which takes advantage of modern multi-core computing architectures.…”
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    Reverse engineering a gene network using an asynchronous parallel evolution strategy
  4. 57744
    “…Our findings suggest that sequential assembly is a basic architectural principle of protective wall formation and requires minimal Golgi sorting functions.…”
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    Selective Condensation Drives Partitioning and Sequential Secretion of Cyst Wall Proteins in Differentiating Giardia lamblia
  5. 57745
    “…CONCLUSIONS AND SIGNIFICANCE: This study provides molecular evidence explaining anatomical and micro-architectural site-related changes in bone cell function, which is predominantly attributable to alteration in cell transcriptional activity. …”
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    Skeletal Site-Related Variation in Human Trabecular Bone Transcriptome and Signaling
  6. 57746
    “…Instead, the divergence may be attributed to the fast evolution of orthologous target genes and/or the promoter architectures resulting from the interaction of those binding sites with the RNA polymerase.…”
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    Defining the Plasticity of Transcription Factor Binding Sites by Deconstructing DNA Consensus Sequences: The PhoP-Binding Sites among Gamma/Enterobacteria
  7. 57747
    “…We found that the architectural structure of the network provides constraints and functional innovations for miRNA evolution and that miRNAs showed different and even opposite evolutionary patterns from TFs and other protein-coding genes. …”
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    microRNA evolution in a human transcription factor and microRNA regulatory network
  8. 57748
    por Zhang, Sheng, Eckstein, Miguel P.
    Publicado 2010
    “…But which of these two neural architectures is favored by evolution? Successful visual search is life-critical and here we investigate the evolution and optimality of neural mechanisms mediating perception and eye movement actions for visual search in natural images. …”
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    Evolution and Optimality of Similar Neural Mechanisms for Perception and Action during Search
  9. 57749
    “…Based on the crystal structure, we have generated possible dimer models and found that architectures of all of these models are incompatible with binding to actin filament but not to actin monomer. …”
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    Crystal Structure of the Formin mDia1 in Autoinhibited Conformation
  10. 57750
    “…CONCLUSIONS/SIGNIFICANCE: Our protein redistribution method does not present the architectural requirement of re-constructing a transcription factor as any of the two-hybrid systems do. …”
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    IC-Tagging and Protein Relocation to ARV muNS Inclusions: A Method to Study Protein-Protein Interactions in the Cytoplasm or Nucleus of Living Cells
  11. 57751
    por Wywial, Ewa, Singh, Shaneen M
    Publicado 2010
    “…Our classification of fifteen Arabidopsis FYVE proteins at the outset reveals unique domain architectures for FYVE containing proteins, which are not paralleled in other organisms. …”
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    Identification and structural characterization of FYVE domain-containing proteins of Arabidopsis thaliana
  12. 57752
    “…Therefore, simulations may assist in designing novel gene network architectures consisting of tetracycline operon components.…”
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    Stochastic simulations of the tetracycline operon
  13. 57753
    “…We discuss these results in comparison with recent findings in stick insects that share similar neural and body architectures, and argue that the two species may exemplify opposite extremes of a fast–slow locomotion continuum, mediated through different intersegment coordination strategies.…”
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    Intersegmental Coordination of Cockroach Locomotion: Adaptive Control of Centrally Coupled Pattern Generator Circuits
  14. 57754
    “…The morphological and architectural complexity of these biofilms were evaluated by scanning electron and confocal scanning laser microscopy. …”
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    Development of a High-Throughput Candida albicans Biofilm Chip
  15. 57755
    “…Rare syntenic conservation, sequence duplication, and the use of both DNA strands to encode genes are signature architectural features defining mitochondrial genomes of enoplean nematodes. …”
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    Rampant gene rearrangement and haplotype hypervariation among nematode mitochondrial genomes
  16. 57756
    “…Graph-based computational network analysis has proven a powerful tool to quantitatively characterize functional architectures of the brain. However, the test-retest (TRT) reliability of graph metrics of functional networks has not been systematically examined. …”
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    Graph Theoretical Analysis of Functional Brain Networks: Test-Retest Evaluation on Short- and Long-Term Resting-State Functional MRI Data
  17. 57757
    “…Classes of genes based on expression pattern, disease involvement, or types of binding sites present can be readily compared in order to assess common "architectural" structures in the regulatory regions. …”
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    The NFI-Regulome Database: A tool for annotation and analysis of control regions of genes regulated by Nuclear Factor I transcription factors
  18. 57758
    “…RESULTS: We present PASHA, a parallelized short read assembler using de Bruijn graphs, which takes advantage of hybrid computing architectures consisting of both shared-memory multi-core CPUs and distributed-memory compute clusters to gain efficiency and scalability. …”
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    Parallelized short read assembly of large genomes using de Bruijn graphs
  19. 57759
    por Steinke, G. Karl, Galán, Roberto F.
    Publicado 2011
    “…Applying mathematical techniques for inverse problems, we have reverse-engineered network architectures that generate characteristic dynamics of actual brains, including spindles and sharp waves, which appear in the power spectrum as frequency bands superimposed on a non-oscillatory background dominated by low frequencies. …”
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    Brain Rhythms Reveal a Hierarchical Network Organization
  20. 57760
    “…Together the data show striking architectural homology between the nucleocapsid helix of rhabdoviruses and filoviruses, but unexpected, fundamental differences in the mechanisms by which the nucleocapsids are then assembled together with matrix proteins and initiate membrane envelopment to release infectious virions, suggesting that the viruses have evolved different solutions to these conserved assembly steps.…”
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    Cryo-Electron Tomography of Marburg Virus Particles and Their Morphogenesis within Infected Cells
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