“…We developed simple computational models to find system architectures that recapitulated the quantitative phenotypes of the mutants. …”
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“…Our finding that HMGB1 binds more tightly to a RAG1–DNA complex over RAG1 or DNA alone provides an explanation for the stable integration of this typically transient architectural protein in the V(D)J recombinase complex throughout recombination. …”
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“…These data challenge the notion of a singular or unitary mode of comprehension and instead support the view that the left and right hemispheres instantiate unique, complementary language comprehension architectures in parallel.…”
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“…Therefore, developing statistical learning models for predicting phenotypic values from all available molecular information that are capable of capturing complex genetic network architectures is of great importance. Bayesian kernel ridge regression is a non-parametric prediction model proposed for this purpose. …”
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“…Cilia are architecturally complex organelles that protrude from the cell membrane and have signalling, sensory and motility functions that are central to normal tissue development and homeostasis. …”
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“…Viruses built with this architectural principle infect hosts in all three domains of cellular life. …”
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“…The derived averages are exact for fixed out-degree network architectures and approximate for fixed in-degree. We demonstrate how taking into account fluctuations in the linearization procedure increases the accuracy of the effective theory and we explain the class dependent differences between covariances in the time and the frequency domain. …”
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“…LSECs participate in liver metabolism, clearance of pathological agents, immunological responses, architectural maintenance of the liver and synthesis of growth factors and cytokines. …”
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“…They are closely related and have similar domain architectures, and their phylogenetic grouping follows the genome duplications. …”
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“…Isolated smaller fields at the central fovea and ∼6 mm nasal to the fovea at the depths of the choriocapillaris and Sattler's layer show vasculature structures consistent with established architectural morphology from histological and electron micrograph corrosion casting studies. …”
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“…The High-Mobility Group AT-Hook 1 (HMGA1) protein is an architectural transcription factor that binds to AT-rich sequences in the promoter region of DNA and functions as a specific cofactor for gene activation. …”
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“…Drawing from practitioner and staff perspectives within each center, the analysis illuminates perceived value factors and core challenges of interprofessional collaborative care, as well as underscores standout facilitators and best practices supporting the sustainability of integrative practices with an emphasis on communication forums, internal culture, and architectural design. Although the meta-findings address key barriers to multidisciplinary collaboration, the merits of converging healing paradigms in clinical practice is highlighted and a fundamental “bending” towards successful integration is celebrated. …”
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“…High mobility group nucleosome-binding protein 5 (HMGN5) is a chromatin architectural protein that binds specifically to nucleosomes and reduces the compaction of the chromatin fiber. …”
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“…Here we highlight the interaction between evolutionary and developmental mechanisms to produce distributed and overlapping functional architectures in the brain. These adaptive mechanisms must be robust to perturbations that might disrupt critical information processing and action selection, but must also recognize useful new sources of information arising from internal genetic or environmental variability, when those appear. …”
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“…Two DBP-RII molecules sandwich either one or two DARC ectodomains, creating distinct heterotrimeric and heterotetrameric architectures. The DARC N-terminus forms an amphipathic helix upon DBP-RII binding. …”
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“…Despite low sequence similarity, corresponding domains have the same fold confirming the overall architectural similarity of orthomyxovirus polymerases. …”
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“…Among patients with malignant calcifications, 54 showed calcifications alone, 40 occurred with an architectural distortion (AD) and 93 with a mass. Calcifications were observed inside the tumor in 44% of patients and outside in 56%, with similar pCR rates and patterns of change. …”
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“…[Image: see text] Nanoparticles with unconventional shapes may exhibit different types of assembly architectures that depend critically on the environmental conditions under which they are formed. …”
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“…Our results support the hypotheses that the proteomes of superkingdom Eukarya evolved via genome expansion mechanisms that were directed towards innovating new domain architectures for regulatory and extra/intracellular process functions needed for example to maintain the integrity of multicellular structure or to interact with environmental biotic and abiotic factors (e.g., cell signaling and adhesion, immune responses, and toxin production). …”
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“…We have followed the notion of modularity and phenotypic integration in order to understand the architectural differences observed within the sample. …”
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