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  1. 57921
    “…These results proved that quantum-mechanical simulations of small proteins, both free and in their crystalline state, are now feasible in a reasonable amount of time, by programs capable of exploiting high performance computing architectures, allowing the study of protein properties not easily amenable through classical force fields.…”
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    Elucidating the fundamental forces in protein crystal formation: the case of crambin
  2. 57922
    “…By developing relationships of damage progression with bone's micro-architectural indices (density and fabric) the study also provides an aid for the creation of more precise macroscale continuum models, which are likely to improve clinical predictions.…”
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    Using Non-linear Homogenization to Improve the Performance of Macroscopic Damage Models of Trabecular Bone
  3. 57923
    “…Decoding the chain from genes to cognition requires detailed insights how areas with specific gene activities and microanatomical architectures contribute to brain function and dysfunction. …”
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    Integration of transcriptomic and cytoarchitectonic data implicates a role for MAOA and TAC1 in the limbic-cortical network
  4. 57924
    “…Therefore, once the possible existence of radon in any underground building has been verified, regardless of the characteristics of the soil, the importance of defining and unifying the regulations on different levels of radon in all architectural constructions is evident. Medical and health science agencies, including the World Health Organization, consider that radon gas is a very harmful element for people. …”
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    The Radon Gas in Underground Buildings in Clay Soils. The Plaza Balmis Shelter as a Paradigm
  5. 57925
    “…METHOD: We undertook detailed micro-CT comparisons of trabecular and cortical bone, multiple structural/architectural parameters and finite element modelling (FEM) of the tibia from male and female STR/Ort and CBA mice at 8–10 (pre-OA), 18–20 (OA onset) and 40 + weeks (advanced OA) of age. …”
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    Sexually dimorphic tibia shape is linked to natural osteoarthritis in STR/Ort mice
  6. 57926
    por Woo, Hyung Jun, Reifman, Jaques
    Publicado 2018
    “…BACKGROUND: Investigation of the genetic architectures that influence the behavioral traits of animals can provide important insights into human neuropsychiatric phenotypes. …”
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    Collective interaction effects associated with mammalian behavioral traits reveal genetic factors connecting fear and hemostasis
  7. 57927
    “…[Image: see text] Dynamic single-chain polymeric nanoparticles (SCPNs) are intriguing, bioinspired architectures that result from the collapse or folding of an individual polymer chain into a nanometer-sized particle. …”
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    Catalytically Active Single-Chain Polymeric Nanoparticles: Exploring Their Functions in Complex Biological Media
  8. 57928
    “…CONCLUSION: Chronic stroke patients have a thicker ATFL on both the affected and unaffected sides, compared with healthy individuals. This architectural feature of the ATFL may be a result of equinovarus deformity together with spastic muscles. …”
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    Assessment of the Anterior Talofibular Ligament Thickness in Patients with Chronic Stroke: An Ultrasonographic Study
  9. 57929
    “…Light influences essential developmental switches in plants ranging from germination or transition to flowering, photomorphogenesis, as well as switches in response to shade avoidances and architectural changes occurring during phototropism. …”
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    Phytochrome and Phytohormones: Working in Tandem for Plant Growth and Development
  10. 57930
    “…CTCF is an evolutionarily conserved and ubiquitously expressed architectural protein regulating a plethora of cellular functions via different molecular mechanisms. …”
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    Poly(ADP-ribosyl)ation associated changes in CTCF-chromatin binding and gene expression in breast cells
  11. 57931
    “…The histological, architectural, and cytological features met the diagnostic criteria of CCV-PTC. …”
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    Columnar Cell Variant of Papillary Thyroid Carcinoma: Ultrasonographic and Clinical Differentiation between the Indolent and Aggressive Types
  12. 57932
    “…However, PDAC is also considered to owe its intractability to other critical factors such as cellular interaction between tumor cells and tumor microenvironment as well as architectural barriers, which increases in therapeutic resistance. …”
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    Stromal mesenchymal stem cells facilitate pancreatic cancer progression by regulating specific secretory molecules through mutual cellular interaction
  13. 57933
    “…One hundred sixty-six resected carcinoid tumors of the lung were analyzed for a variety of clinical and pathologic features, including histology subtype, mitotic rate, Ki67 index, necrosis, invasive pattern, architectural pattern, cell morphology, sustentacular cells, neuroendocrine hyperplasia, and orthopedia homeobox protein (OTP) and TTF-1 immunohistochemical expressions. …”
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    Clinical and Pathologic Characteristics of Pulmonary Carcinoid Tumors in Central and Peripheral Locations
  14. 57934
    “…The up-sampling shortcuts reduced the overall training time of the network, 161 min compared with 253 min without the architectural addition.…”
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    Integration of spatial information in convolutional neural networks for automatic segmentation of intraoperative transrectal ultrasound images
  15. 57935
    “…Each repeat contains a high density of binding sites for the architectural organization protein CCCTC-binding factor (CTCF) which exclusively associates with the Xi allele in normal cells. …”
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    Characterization of the ICCE Repeat in Mammals Reveals an Evolutionary Relationship with the DXZ4 Macrosatellite through Conserved CTCF Binding Motifs
  16. 57936
    “…The increase in the affinity data available in DT knowledge-bases allows the use of advanced learning techniques such as deep learning architectures in the prediction of binding affinities. …”
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    DeepDTA: deep drug–target binding affinity prediction
  17. 57937
    “…We consider evolution in two traits describing the top‐heaviness and width‐to‐height ratio of crowns, shaped by trade‐offs reflecting the costs and benefits of alternative architectures. In top‐heavy trees, most of the leaves are at the top half of the trunk. …”
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    Latitudinal effects on crown shape evolution
  18. 57938
    “…Such requirements are thought to constrain the topological and spatial organization of these systems, but at the same time, different kinds of distribution networks may exhibit variable architectural features within those general constraints. …”
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    Comparing two classes of biological distribution systems using network analysis
  19. 57939
    “…For prediction, we present a longitudinal Siamese neural-network (LSN) with novel architectural modules for combining multimodal data from two timepoints. …”
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    Modeling and prediction of clinical symptom trajectories in Alzheimer’s disease using longitudinal data
  20. 57940
    “…BACKGROUND: Invasion of epithelial cells into the connective tissue brings about massive morphological and architectural changes in the underlying stroma. Myofibroblasts reorganize the stroma to facilitate the movement of tumor cells leading to metastasis. …”
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    An Immunohistochemical and Polarizing Microscopic Study of the Tumor Microenvironment in Varying Grades of Oral Squamous Cell Carcinoma
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