“…Recent advances in visualizing the ultrastructure and topology of presynaptic protein architectures have started to elucidate how scaffold proteins establish “nanodomains” that connect voltage-gated Ca(2+) channels (VGCCs) physically and functionally with release-ready SVs. …”
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“…Quantifying these variations may help understand functional brain architectures – and inform clinical applications. In the present study, we investigated the consistency of effective connectivity within and between subjects, as well as potential sources of variability (e.g., hemispheric asymmetry). …”
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“…Our results suggest that when genetic architectures of traits favor Bayesian methods, the accuracy of multi-trait GBLUP can be as high as the Bayesian method if SNPs are weighted by the Bayesian posterior (co)variances.…”
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“…The transformed data were used as input into several neural network architectures designed to evaluate efficacy of the supplied data and also the networks’ capability at exploiting relationships that could underlie the data. …”
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“…The greater cane rat (Thryonomys swinderianus) demonstrated numerous dermal architectural peculiarities hitherto unreported. This investigation assessed and evaluated certain histologic features of skin samples from the fore and hind limbs, the neck, head, proximal to the ear and oro-nasal regions for follicular evaluations and micro anatomic assessments in the adult species. …”
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“…Here, through comparative study of the GP1 glycoprotein architectures of Old World Loei River virus and New World Whitewater Arroyo virus, we show that these rearrangements are restricted to Old World arenaviruses and are not induced solely by the pH change that is associated with virus endosomal trafficking. …”
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“…After the treatment, right femora were collected to measure the length and biomechanical properties, and left femora were gathered to study the micro architectural changes while tibia were collected to measure the dry weight. …”
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“…Capitalizing on a sample of 780 youth imaged as part of the Philadelphia Neurodevelopmental Cohort, this hypergraph representation of resting‐state functional MRI data reveals three distinct classes of subnetworks (hyperedges): clusters, bridges, and stars, which respectively represent homogeneously connected, bipartite, and focal architectures. Cluster hyperedges show a strong resemblance to previously‐described functional modules of the brain including somatomotor, visual, default mode, and salience systems. …”
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“…Quantitative traits were simulated in three scenarios considering three degrees of dominance (d/a = 0, 0.5 and 1) and two broad sense heritabilities (h(2) = 0.30 and 0.70), totaling six genetic architectures. To evaluate prediction reliability, a model (RR-BLUP) was trained in one generation and used to predict the following generations of mating systems. …”
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“…We searched 38 plant genome sequences including core eudicots, monocots, gymnosperms, fern, lycophytes, bryophytes, charophytes, chlorophytes, glaucophytes, and rhodophytes for lectin motifs, performed an extensive comparative analysis of lectin domain architectures, and determined the phylogenetic and evolutionary history of lectins in the plant lineage. …”
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“…Results revealed that PILE 100 mice exhibited improved blood biochemistry, maintained a higher body weight, had decreased hyperglycemia, and restored islet architectures compared to non-treated STZ mice. Significantly, PILE 100 decreased levels of inflammatory response markers interferon-γ (IFN-γ), tumor necrosis factor-α (TNF-α), and interlukin1-β (IL-1β), concomitant with the inhibition of caspase-3, caspase-8, capsepase-9, phosphorylation of signal transducer and activator of transcription 1 (pSTAT1), nuclear factor-κBp65 (NF-κBp65), and inducible nitric oxide synthase (iNOS). …”
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“…Within the framework of designing new self-assembled metallosupramolecular architectures for drug delivery, seven [Pd(2)L(4)](4+) metallacages (L = 2,6-bis(pyridine-3-ylethynyl)pyridine) featuring different groups in exo-position, selected to enhance the cage solubility in aqueous environment, were synthesized. …”
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“…Thus, while conditional gene essentiality is usually driven by genetic interactions associated with complex modifier architectures, our analysis also highlights the role of functionally related, genetically independent, and rare variants.…”
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“…The viable areas exhibited slit vascular-like spaces and micropapillary architectural patterns with stromal eosinophilia. Focal small cellular nests with features of SCC were present. …”
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“…We discuss the possible significance of BldC as an evolutionary link between MerR family transcription factors and DNA architectural proteins.…”
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“…Our main contributions are the following three things. (1) We propose a concise CNN model for OCT images, which outperforms the existing large CNN models using VGG16 and GoogLeNet architectures. (2) We propose an algorithm called Expressive Gradients (EG) that extends the existing Integrated Gradients (IG) algorithm so as to exploit not only the input-level attribution map, but also the high-level attribution maps. …”
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“…CONCLUSIONS: Switching to aflibercept in DME patients with an unsatisfactory response to previous anti-VEGF injections provided acceptable short-term visual and retinal architectural improvement.…”
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“…This switch alters the degree of enhancement and the circular dichroism (CD) pattern, suggesting a structural transition into a chiral object with a different shape. This architectural chirality transformation presents a new approach to forming dynamic coordination-assemblies, which have transformable geometric chiral structures.…”
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“…Dynamical properties of branched polymer melts are determined by the polymer molecular weights and architectures containing junction points. Relaxation of entangled symmetric star polymers proceeds via arm-retraction and constraint release (CR). …”
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“…Coordinated changes of DNA (de)methylation, nucleosome positioning, and chromatin binding of the architectural protein CTCF play an important role for establishing cell-type–specific chromatin states during differentiation. …”
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