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  1. 58561
    “…In preclinical cancer studies, three‐dimensional (3D) cell spheroids and aggregates are preferred over monolayer cell cultures due to their architectural and functional similarity to solid tumors. …”
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    Fluorescent multiplexing of 3D spheroids: Analysis of biomarkers using automated immunohistochemistry staining platform and multispectral imaging
  2. 58562
    “…CONCLUSION: BMD losses incurred by secondary hyperparathyroidism recover rapidly after parathyroidectomy, particularly at sites of trabecular bone. Bone architectural parameters, measured as the TBS and by HSA, also improve. …”
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    Changes to bone mineral density, the trabecular bone score and hip structural analysis following parathyroidectomy: a case report
  3. 58563
    “…On the other hand, in the BRNN method, the architectures of one and two layers that used only the pureline function showed better results of prediction, with values ranging from 0.21 (pilodyn penetration) to 0.71 (flowering traits). …”
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    Genome-Wide Prediction of Complex Traits in Two Outcrossing Plant Species Through Deep Learning and Bayesian Regularized Neural Network
  4. 58564
    “…Here we show that convolutional neural networks (CNNs) can be systematically applied across cancer types, enabling comparisons to reveal shared spatial behaviors. We develop CNN architectures to analyze 27,815 hematoxylin and eosin scanned images from The Cancer Genome Atlas for tumor/normal, cancer subtype, and mutation classification. …”
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    Deep learning-based cross-classifications reveal conserved spatial behaviors within tumor histological images
  5. 58565
    “…Different state-of-the-art convolutional neural network (CNN) architectures with region proposals have been trained using transfer learning to automatically identify seeds within petri dishes and to predict whether the seeds germinated or not. …”
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    Accurate machine learning-based germination detection, prediction and quality assessment of three grain crops
  6. 58566
    “…The expanded IAPs have been subjected to frequent domain shuffling, which has in turn shaped their architectural diversity. Further, we observed that extant IAPs exhibit dynamic and orchestrated expression patterns among tissues and in response to different environmental stressors. …”
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    The hard clam genome reveals massive expansion and diversification of inhibitors of apoptosis in Bivalvia
  7. 58567
    “…We benchmarked three machine learning architectures previously applied to the WGS-AST problem on a set of 8,704 genome assemblies from five clinically relevant pathogens across 77 species-compound combinations collated from public databases. …”
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    Learning From Limited Data: Towards Best Practice Techniques for Antimicrobial Resistance Prediction From Whole Genome Sequencing Data
  8. 58568
    por Tanbeer, Syed K, Sykes, Edward R
    Publicado 2021
    “…In this paper we present MyHealthPortal, the architectural framework that we designed and developed to support the system, and the results of a usability study conducted from real field studies. …”
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    MyHealthPortal – A web-based e-Healthcare web portal for out-of-hospital patient care
  9. 58569
    “…To reach this goal we trained and tested eight promising detectors based on different neural network architectures (MobileNet, ResNet-50, ResNet-101, Inception ResNet, NASNet) using clinical angiography data of 100 patients. …”
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    Real-time coronary artery stenosis detection based on modern neural networks
  10. 58570
    “…The new high-performance module allows for an efficient use of single- and multiple-GPU architectures ranging from research laboratories to modern supercomputer centers. …”
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    Tinker-HP: Accelerating Molecular Dynamics Simulations of Large Complex Systems with Advanced Point Dipole Polarizable Force Fields Using GPUs and Multi-GPU Systems
  11. 58571
    “…RESULTS: We characterise the mutational landscape of 1.3 million gene-regulatory and chromatin architectural elements in 2419 whole cancer genomes with transcriptional and pathway activity, functional conservation and recurrent driver events. …”
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    Functional and genetic determinants of mutation rate variability in regulatory elements of cancer genomes
  12. 58572
    “…Here, we hypothesized a sepsis-induced differential occupancy of the CCCTC-Binding Factor (CTCF), an architectural protein and superordinate regulator of transcription, inside the Major Histocompatibility Complex Class II (MHC-II) region in patients with postoperative sepsis, contributing to an altered monocytic transcriptional response during critical illness. …”
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    Postoperative abdominal sepsis induces selective and persistent changes in CTCF binding within the MHC-II region of human monocytes
  13. 58573
    “…Conclusions: Partial immunostaining with architecturally distinct p16(INK4a) immunoexpression patterns may prove significant in stratifying characteristic clinicopathological subgroups among LSCC. …”
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    Different patterns of p16(INK4a) immunohistochemical expression and their biological implications in laryngeal squamous cell carcinoma
  14. 58574
    “…Herein, we implement and access machine learning architectures to ascertain models that differentiate healthy from apoptotic cells using exclusively forward (FSC) and side (SSC) scatter flow cytometry information. …”
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    Cell morphology-based machine learning models for human cell state classification
  15. 58575
    “…Utilizing a coupled opto-electro-thermal modeling we evaluate our nano-micro-scale cooler also in the case of selected, highly-efficient Si-based photovoltaic architectures, where we achieve an efficiency enhancement of ~ 3.1%, which is 2.3 times higher compared to common anti-reflection layers, while the operating temperature of the device also decreases. …”
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    Combined nano and micro structuring for enhanced radiative cooling and efficiency of photovoltaic cells
  16. 58576
    “…Our findings suggest that neuronal dynamic leak serves the beneficial function of protecting recurrent neuronal circuitry from the self-induction of spurious high frequency signals, thereby permitting the brain to utilize this architectural circuitry component regardless of network size or recurrency.…”
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    A Non-spiking Neuron Model With Dynamic Leak to Avoid Instability in Recurrent Networks
  17. 58577
    “…Based on these properties, new high-resolution cryo-electron tomography data and architectural similarities between the Spa33 and flagellar FliM-FliN complexes, we provide a preliminary model of the Spa33 heterotrimers within the SP pods. …”
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    Composition and Biophysical Properties of the Sorting Platform Pods in the Shigella Type III Secretion System
  18. 58578
    “…CONCLUSIONS: In a small and structured introduced population of P. trichocarpa, we find complex genetic architectures underlying all phenology and growth traits, and identify multiple putative candidate genes despite the limitations of the study population. …”
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    The genetic basis of adaptation in phenology in an introduced population of Black Cottonwood (Populus trichocarpa, Torr. & Gray)
  19. 58579
    “…INTRODUCTION: Several factors contribute to the reduction of the mobility in ICU), such as the use of sedatives, severity, invasive devices, acute clinical instability, lack of resources, the culture of immobility, architectural barriers and the own weakness developed in the ICU. …”
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    Association of the mobility level of critically ill adult patients with the success of extubation: protocol for a cohort study
  20. 58580
    “…We found a set of uncharacterized ATPase proteins with nuclease and protease activities, displaying unique domain architectures that are energy intensive based on the presence of multiple ATPase domains. …”
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    Diverse ATPase Proteins in Mobilomes Constitute a Large Potential Sink for Prokaryotic Host ATP
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