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  1. 58681
    por Garris, David R
    Publicado 2005
    “…The lipidemia-induced alterations in intracellular organelle and nuclear architectures suggests that the metabolic disturbances in glucose and lipid metabolic cascades in diabetes (db/db) mutants disrupts cytointegrity, culminating in nuclear disregulation (as indicated by lipoapoptosis) and eventual premature reproductive tract organoinvolution and resultant, manifest, reproductive sterility.…”
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    Diabetes (db/db) mutation-induced endometrial epithelial lipoapoptosis: Ultrastructural and cytochemical analysis of reproductive tract atrophy
  2. 58682
    “…After menopause, sex hormone deficiency is associated with increased remodeling rate and negative bone balance, leading to accelerated bone loss and micro-architectural defects, resulting into increased bone fragility. …”
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    Assessment of soy phytoestrogens' effects on bone turnover indicators in menopausal women with osteopenia in Iran: a before and after clinical trial
  3. 58683
    “…CONCLUSION: The dissonance between global versus local network divergence suggests that the interspecies similarity of the global network properties is of limited biological significance, at best, and that the biologically relevant aspects of the architectures of gene coexpression are specific and particular, rather than universal. …”
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    Global similarity and local divergence in human and mouse gene co-expression networks
  4. 58684
    “…To understand their functional associations, we sought and recovered several conserved gene neighborhoods and domain architectures. These included novel associations involving diverse sulfur metabolism proteins, siderophore biosynthesis and the gene encoding the transfer mRNA binding protein SmpB, as well as domain fusions between Ub-like domains and PIN-domain related RNAses. …”
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    The prokaryotic antecedents of the ubiquitin-signaling system and the early evolution of ubiquitin-like β-grasp domains
  5. 58685
    “…Histologically, all showed classic anastomosing channels lined by plump hyperchromatic cells, though most showed epithelioid cytology and some showed solid architectural pattern. One patient had multiple metastatic recurrences but eventual outcome was not available, and 1 patient died a month after diagnosis from stroke but no autopsy was performed. …”
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    Primary angiosarcoma of the testis: report of a rare entity and review of the literature
  6. 58686
    “…The dZ:dP pair and these polymerases, should be useful in dynamic architectures for sequencing, molecular-, systems- and synthetic-biology.…”
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    Enzymatic incorporation of a third nucleobase pair
  7. 58687
    “…Variants in genes involved in molecular mechanisms of cellular plasticity, in genes involved in the development of underlying neural architectures, and in genes involved in neurodevelopment and in the ongoing function of terminally differentiated neurons may underlie the phenotypic variation of intelligence and explain instances of intellectual impairment.…”
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    Complex aetiology of an apparently Mendelian form of Mental Retardation
  8. 58688
    Publicado 1991
    “…To examine the molecular and architectural differences of nebulin size-variants, we carried out immunoelectron microscopic studies to map out epitope profiles of nebulin variants in these muscles. …”
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    Nebulin as a length regulator of thin filaments of vertebrate skeletal muscles: correlation of thin filament length, nebulin size, and epitope profile
  9. 58689
    “…We identified large numbers of methyl-accepting chemotaxis protein (MCP) homologs that have diverse sensing domain architectures and generate a potential for sensing a great variety of environmental signals. …”
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    Comparative genomics of Geobacter chemotaxis genes reveals diverse signaling function
  10. 58690
    por Durek, Pawel, Walther, Dirk
    Publicado 2008
    “…RESULTS: Analyzing yeast data, we detected long-range correlations between shortest paths between proteins in both network types suggesting a mutual correspondence of both network architectures. We discovered that the organizing principles of physical interactions between metabolic enzymes differ from the general PIN of all proteins. …”
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    The integrated analysis of metabolic and protein interaction networks reveals novel molecular organizing principles
  11. 58691
    “…BACKGROUND: The architectural structure of cellular networks provides a framework for innovations as well as constraints for protein evolution. …”
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    Protein evolution on a human signaling network
  12. 58692
    “…Such changes in publication standards and database architectures will enable researchers to compile current knowledge about the metabolome of species, which may extend to derived information such as spectral libraries, organ-specific metabolites, and cross-study comparisons.…”
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    How Large Is the Metabolome? A Critical Analysis of Data Exchange Practices in Chemistry
  13. 58693
    “…METHODS: To confront these issues, harnessing expertise in human-computer interaction (HCI), high-performance rendering and distributed systems, and guided by bioinformaticians and end-user biologists, we are building reusable software components that, together, create a toolkit that is both architecturally sound from a computing point of view, and addresses both user and developer requirements. …”
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    Visualising biological data: a semantic approach to tool and database integration
  14. 58694
    “…The identified proteins have diverse molecular architectures and can interact with other proteins, as well as with lipids and nucleic acids. …”
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    Proteins recruited by SH3 domains of Ruk/CIN85 adaptor identified by LC-MS/MS
  15. 58695
    “…The implementation of differential expression detection methods has been parallelised leading to significant decreases in processing time on a range of computer architectures. puma incorporates the first R implementation of an uncertainty propagation version of principal component analysis, and an implementation of a clustering method based on uncertainty propagation. …”
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    puma: a Bioconductor package for propagating uncertainty in microarray analysis
  16. 58696
    “…There are two main advantages of the LONI Pipeline over other graphical analysis workflow architectures. It is built as a distributed Grid computing environment and permits efficient tool integration, protocol validation and broad resource distribution. …”
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    Efficient, Distributed and Interactive Neuroimaging Data Analysis Using the LONI Pipeline
  17. 58697
    “…BACKGROUND: Destruction of the architectural and subsequently the functional integrity of the lung following pulmonary viral infections is attributable to both the extent of pathogen replication and to the host-generated inflammation associated with the recruitment of immune responses. …”
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    Inducible Bronchus-Associated Lymphoid Tissue Elicited by a Protein Cage Nanoparticle Enhances Protection in Mice against Diverse Respiratory Viruses
  18. 58698
    “…Higher numbers of taxonomic group specific domains co-occur with the more abundant domain (FYVE/PX) indicating that group-specific rare domain architectures might have emerged to accomplish certain group-specific functions.…”
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    Comparative genomics reveals selective distribution and domain organization of FYVE and PX domain proteins across eukaryotic lineages
  19. 58699
    por Haque, Saadiya, van Kirk, Robert
    Publicado 2009
    “…All three cases had architectural features consistent with an HHV-8-negative morphology. …”
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    Three patients with both Hodgkin's lymphoma and Castleman's disease: Clinicopathologic correlations and lack of association with HHV-8
  20. 58700
    “…Of 30,468 gene models in the genome, 557 varied across these 500 genomes. 226 of these polymorphic gene models (40%) were perfectly correlated with individual SNPs, all of which were within or immediately proximal to the affected gene. The genetic architectures of the other 321 were more complex, with several examples of SNP epistasis that would have been difficult to predict a priori. …”
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    Exploring the Genetic Basis of Variation in Gene Predictions with a Synthetic Association Study
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