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  1. 59161
    “…In a study on large biomedical datasets we show that our approach scales well on multi-processor and multi-GPU architectures. On a four-GPU system we demonstrate that our approach can be more than 100-times faster than its single-processor counterpart. …”
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    Scalable non-negative matrix tri-factorization
  2. 59162
    “…Although a variety of radio frequency (RF) coil architectures have been developed for imaging at UHF conditions, they usually are specialized for small volumes of interests (VoI). …”
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    Metamaterial-based transmit and receive system for whole-body magnetic resonance imaging at ultra-high magnetic fields
  3. 59163
    “…Histological examination of colon sections of colitis-free mice remained largely architecturally physiologic and mostly free of leukocyte infiltration when compared with DSS-treated animals. …”
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    Co-Stimulation-Impaired Bone Marrow-Derived Dendritic Cells Prevent Dextran Sodium Sulfate-Induced Colitis in Mice
  4. 59164
    “…In yeast (Saccharomyces cerevisiae) and humans, biochemical studies and structural analysis revealed interaction patterns between the subunits and architectures of the clamp loaders. Mutations of ScRFC1/2/3/4/5 lead to loss of cell viability and defective replication. …”
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    Subunit Interaction Differences Between the Replication Factor C Complexes in Arabidopsis and Rice
  5. 59165
    “…HMGA1 (high mobility group A1) is a nonhistone architectural chromosomal protein that functions mainly as a dynamic regulator of chromatin structure and gene transcription. …”
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    Transcriptional Regulation of Glucose Metabolism: The Emerging Role of the HMGA1 Chromatin Factor
  6. 59166
    “…In current study, 16 putative chitin genes (CaChi) were retrieved from the latest pepper genome database, and were classified into four distinct classes (I, III, IV and VI) based on their sequence structure and domain architectures. Furthermore, the structure of gene, genome location, gene duplication and phylogenetic relationship were examined to clarify a comprehensive background of the CaChi genes in pepper. …”
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    Classification and Genome-Wide Analysis of Chitin-Binding Proteins Gene Family in Pepper (Capsicum annuum L.) and Transcriptional Regulation to Phytophthora capsici, Abiotic Stresses and Hormonal Applications
  7. 59167
    “…The HTLV-1 provirus has an intrinsic pattern of epigenetic modifications that is independent of both the provirus insertion site and the chromatin architectural protein CTCF which binds to the HTLV-1 provirus.…”
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    Epigenetic changes around the pX region and spontaneous HTLV-1 transcription are CTCF-independent
  8. 59168
    “…P(Ertip1+35Smini) may provide a valuable and potent molecular-tool for comprehensive investigation of a gene function related to root growth and development as well as molecular engineering of root-architectural formation aiming to improve plant growth. …”
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    Molecular identification of a root apical cell-specific and stress-responsive enhancer from an Arabidopsis enhancer trap line
  9. 59169
    “…However, direct assessment of cross-trait associations using susceptibility loci has been challenging due to the complex genetic architectures in most diseases, calling for advantageous methods that could integrate functional interpretation and imply biological mechanisms. …”
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    Investigation of multi-trait associations using pathway-based analysis of GWAS summary statistics
  10. 59170
    “…Our aim in this study was to follow the impact of a unilateral substantia nigra pars compacta (SNpc) lesion in rat on the cortical and hippocampal sleep architectures and their EEG microstructures, as well as the cortico-hippocampal synchronizations of EEG oscillations, and the SS and high voltage sleep spindle (HVS) dynamics during NREM and REM sleep. …”
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    Alterations of Sleep and Sleep Oscillations in the Hemiparkinsonian Rat
  11. 59171
    por Pullen, Sonja, Clever, Guido H.
    Publicado 2018
    “…Years of research on MOFs and MOCs has yielded numerous types of well-defined porous crystals and complex supramolecular architectures. Since various synthetic routes and postsynthetic modification methods have been established, the focus of recent developments has moved toward the preparation of multifunctional systems that are able to mimic the structural and functional complexity of natural enzymes. …”
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    Mixed-Ligand Metal–Organic Frameworks and Heteroleptic Coordination Cages as Multifunctional Scaffolds—A Comparison
  12. 59172
    “…These results allow conclusions to be drawn about the factors that are required for functionally equivalent disulfide isomerase enzymatic activity across structurally diverse protein architectures.…”
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    The atypical thiol–disulfide exchange protein α-DsbA2 from Wolbachia pipientis is a homotrimeric disulfide isomerase
  13. 59173
    “…This study aimed at determining the potential therapeutic effects of Quercetin and Naringenin on cART-induced cyto-architectural, neuro-behavioral and immunohistochemical changes in the hippocampus of the adult Wister rats. …”
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    Combination antiretroviral therapy (cART)-induced hippocampal disorders: Highlights on therapeutic potential of Naringenin and Quercetin
  14. 59174
    “…Moreover, despite no sequence homology, Ec-dGTPase and SAMHD1 share similar active-site and HD motif architectures; however, Ec-dGTPase residues at the end of the substrate-binding pocket mimic Watson–Crick interactions providing guanine base specificity, while a 7-Å cleft separates SAMHD1 residues from dNTP bases, abolishing nucleotide-type discrimination. …”
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    The crystal structure of dGTPase reveals the molecular basis of dGTP selectivity
  15. 59175
    “…We investigated the utility of (1) rare variants and variants known to be determinants of resistance for at least one drug and (2) machine and statistical learning architectures in predicting phenotypic drug resistance to 10 anti-tuberculosis drugs. …”
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    Beyond multidrug resistance: Leveraging rare variants with machine and statistical learning models in Mycobacterium tuberculosis resistance prediction
  16. 59176
    “…This class of models can mimic key in vivo features, including shear stresses and cellular architectures, in ways that cannot be realized by traditional two‐dimensional in vitro models. …”
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    A microfluidic model of human brain (μHuB) for assessment of blood brain barrier
  17. 59177
    “…Nonetheless, the language gives users a powerful and portable way to scale up analyses in many computing architectures. The code for our implementation of a variant calling workflow using Swift/T can be found on GitHub at https://github.com/ncsa/Swift-T-Variant-Calling, with full documentation provided at http://swift-t-variant-calling.readthedocs.io/en/latest/.…”
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    Managing genomic variant calling workflows with Swift/T
  18. 59178
    “…Many server applications today are designed using microservice architectures where components are easier to update. …”
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    DNS/DANE Collision-Based Distributed and Dynamic Authentication for Microservices in IoT †
  19. 59179
    por Daniel, Christel, Kalra, Dipak
    Publicado 2019
    “…The third best paper reports the evaluation of an open source, interoperable, and scalable data quality assessment tool measuring completeness of data items, which can be run on different architectures (EHRs and Clinical Data Warehouses (CDWs) based on PCORnet or OMOP data models). …”
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    Clinical Research Informatics: Contributions from 2018
  20. 59180
    “…Hyperoxia-induced lung injury in neonatal rats has been used as a model of BPD, as indicated by lung architectural change and alveolar simplification that resembles clinical feature of BPD. β-defensin-2 (BD2) plays an important role in lung diseases by inhibiting inflammation response. …”
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    Human β-Defensin-2 Improves Hyperoxia-Induced Lung Structural and Functional Injury in Neonatal Rats
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