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  1. 59581
    “…Furthermore, based on structural bioinformatics data, we speculated that the different action modes among the three GH18 chitinases may be caused by loop differences in their active site architectures. Among them, SsChi18A is probably processive and mainly acts on polysaccharides, while SsChi18B and SsChi18C are likely endo-non-processive and displayed higher activity on the degradation of chitin oligosaccharides. …”
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    A novel thermostable chitinolytic machinery of Streptomyces sp. F-3 consisting of chitinases with different action modes
  2. 59582
    “…One of the master regulators in TNBC progression is the architectural transcription factor HMGA1. This study aimed to further explore the HMGA1 molecular network to identify molecular mechanisms involved in TNBC progression. …”
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    HMGA1 promotes breast cancer angiogenesis supporting the stability, nuclear localization and transcriptional activity of FOXM1
  3. 59583
    “…RESULTS: We develop a suite of ML models, under the banner Aikyatan, including SVM models, random forest variants, and deep learning architectures, for distal regulatory element (DRE) detection. …”
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    AIKYATAN: mapping distal regulatory elements using convolutional learning on GPU
  4. 59584
    “…Two “Reproducible” Artificial Neural Networks with different architectures were developed to predict the risk of developing Intra-Abdominal Abscess Post- Appendectomy: Model (1) 12 Inputs, 3 hidden layers with 12 Neurons each, and 1 Output. …”
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    2438. Using Artificial Neural Networks to Predict Intra-Abdominal Abscess Risk Post-Appendectomy
  5. 59585
    “…The objective of this study is also to shed light into the fundamental localised electronic and energy transfer properties in these new molecularly engineered porous and fluorogenic architectures, aiming in turn to understand how functional porphyrins may exert stacking control over the notoriously disordered local structure present in porous reduced graphene oxide fragments. …”
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    Directed Molecular Stacking for Engineered Fluorescent Three‐Dimensional Reduced Graphene Oxide and Coronene Frameworks
  6. 59586
    “…Future work is needed to validate the identified associations with BD, to formally assess the performance of both approaches under different true genetic architectures, and to apply these approaches to study sex differences in other conditions.…”
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    Statistical methods for testing X chromosome variant associations: application to sex-specific characteristics of bipolar disorder
  7. 59587
    “…A complex trait was simulated assuming alternative genetic architectures. Different scaling factors to blend the inverse of the genomic (G(−1)) and pedigree ([Formula: see text]) relationship matrices were also tested. …”
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    Comparing Alternative Single-Step GBLUP Approaches and Training Population Designs for Genomic Evaluation of Crossbred Animals
  8. 59588
    “…In the past, coupled double quantum dot architectures prepared by molecular beam epitaxy revealed a coupling energy of few millielectron volts, which limits the applications to mostly cryogenic operation. …”
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    Coupled Colloidal Quantum Dot Molecules
  9. 59589
    “…A subset of women were rescanned using HR-pCT after thyroid hormones had been normalized for at least 6 months to determine if there were cortical/trabecular architectural changes that reversed towards normal in these individual cases. …”
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    Bone Microarchitectural Changes in Hyperthyroid Women Compared to a Normal Canadian Cohort
  10. 59590
    “…Conclusion: Glucocorticoid excess predominantly affects trabecular bones (pelvis, ribs, lumbar spine) as compared to cortical bones. Due to micro-architectural changes, reduction in bone strength is disproportionately greater than would be expected from BMD measured by DEXA. …”
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    Recurrent Atraumatic Pelvic Fractures in a Patient With Cushing’s Disease - Is DEXA Scan Really Useful to Predict the Future Fracture Risk?
  11. 59591
    “…They are characterized by different signatures of SOX-dependent neural crest-like stemness and distinct architectures of the cytoskeleton network. Multiple signaling pathways have already been activated from the primary melanoma stage, whereas HIF1α, the major hypoxia-inducible factor, can be exclusively observed in metastatic melanoma cells. …”
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    From Proteomic Mapping to Invasion-Metastasis-Cascade Systemic Biomarkering and Targeted Drugging of Mutant BRAF-Dependent Human Cutaneous Melanomagenesis
  12. 59592
    “…Five face recognition frameworks for WBS were constructed by adopting the VGG-16, VGG-19, ResNet-18, ResNet-34, and MobileNet-V2 architectures, respectively. ImageNet transfer learning was used to avoid over-fitting. …”
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    Automatic Facial Recognition of Williams-Beuren Syndrome Based on Deep Convolutional Neural Networks
  13. 59593
    por Camilli, Matteo, Russo, Barbara
    Publicado 2022
    “…CONTEXT: The microservices architectural style is gaining momentum in the IT industry. …”
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    Modeling Performance of Microservices Systems with Growth Theory
  14. 59594
    “…Three different deep learning architectures (FCN32, U-Net, and SegNet) were trained on the binary contours created by G2. …”
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    A121 QUANTIFYING INTER-OBSERVER VARIABILITY IN THE SEGMENTATION OF RECTAL TUMORS IN ENDOSCOPY IMAGES AND ITS EFFECTS ON DEEP LEARNING
  15. 59595
    “…The histological criteria for classifying endometrial hyperplasia (EH) are based on architectural crowding and nuclear atypia; however, diagnostic agreement among pathologists is poor. …”
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    MicroRNAs as Predictors of Future Uterine Malignancy in Endometrial Hyperplasia without Atypia
  16. 59596
    “…Being able to probe tissues with sub-micrometric diffusion length and quantify new local parameters, transient anomalous diffusion (tAD) would dramatically increase the diagnostic potential of diffusion MRI (DMRI) in detecting collective and sub-micro architectural changes of human tissues due to pathological damage. …”
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    Transient Anomalous Diffusion MRI in Excised Mouse Spinal Cord: Comparison Among Different Diffusion Metrics and Validation With Histology
  17. 59597
    “…CONCLUSION: The 3D-reco and corrosion casting of the murine biliary tree are feasible and provide a straightforward, robust, and reliable (and more economical) procedure for the visualization and quantitative assessment of architectural alterations, in comparative usage with the 2D histology.…”
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    Corrosion Cast and 3D Reconstruction of the Murine Biliary Tree After Biliary Obstruction: Quantitative Assessment and Comparison With 2D Histology
  18. 59598
    “…The concept of conduits as an alternative with different materials and architectures, such as autologous vein conduits or bioartificial nerve conduits, could not replace the nerve graft until today. …”
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    Closing the Gap: Bridging Peripheral Sensory Nerve Defects with a Chitosan-Based Conduit a Randomized Prospective Clinical Trial
  19. 59599
    “…Univariate analysis found that the shape, orientation, margin, posterior features, calculations, architectural distortion, duct changes and suspicious lymph node of breast cancer lesions in ultrasound signs were associated with SLN metastasis. …”
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    A machine learning model based on ultrasound image features to assess the risk of sentinel lymph node metastasis in breast cancer patients: Applications of scikit-learn and SHAP
  20. 59600
    “…The model is trained on 77,980 CT slices, validated on 9748 slices and tested on 12,571 slices. Nine CNN architectures with different layer settings are trained and tested to arrive at the final optimal model. …”
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    CTSC-Net: an effectual CT slice classification network to categorize organ and non-organ slices from a 3-D CT image
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