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  1. 4101
    “…Our results make a strong argument for applying this design and pursuing further research in a surgical patient population. …”
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    Anticipated regret in shared decision-making: a randomized experimental study
  2. 4102
    “…Our data indicate that PD-1 and PD-L1 molecules are biologically relevant regulators of the immune response in high-grade serous ovarian carcinoma, which is an argument for the evaluation of immune checkpoint inhibiting drugs in this tumor entity.…”
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    Prognostic impact of programmed cell death-1 (PD-1) and PD-ligand 1 (PD-L1) expression in cancer cells and tumor-infiltrating lymphocytes in ovarian high grade serous carcinoma
  3. 4103
    por Kettunen, Johannes, Demirkan, Ayşe, Würtz, Peter, Draisma, Harmen H.M., Haller, Toomas, Rawal, Rajesh, Vaarhorst, Anika, Kangas, Antti J., Lyytikäinen, Leo-Pekka, Pirinen, Matti, Pool, René, Sarin, Antti-Pekka, Soininen, Pasi, Tukiainen, Taru, Wang, Qin, Tiainen, Mika, Tynkkynen, Tuulia, Amin, Najaf, Zeller, Tanja, Beekman, Marian, Deelen, Joris, van Dijk, Ko Willems, Esko, Tõnu, Hottenga, Jouke-Jan, van Leeuwen, Elisabeth M, Lehtimäki, Terho, Mihailov, Evelin, Rose, Richard J., de Craen, Anton J.M., Gieger, Christian, Kähönen, Mika, Perola, Markus, Blankenberg, Stefan, Savolainen, Markku J., Verhoeven, Aswin, Viikari, Jorma, Willemsen, Gonneke, Boomsma, Dorret I., van Duijn, Cornelia M., Eriksson, Johan, Jula, Antti, Järvelin, Marjo-Riitta, Kaprio, Jaakko, Metspalu, Andres, Raitakari, Olli, Salomaa, Veikko, Slagboom, P. Eline, Waldenberger, Melanie, Ripatti, Samuli, Ala-Korpela, Mika
    Publicado 2016
    “…Our findings strengthen the argument for safe LPA-targeted intervention to reduce cardiovascular risk.…”
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    Genome-wide study for circulating metabolites identifies 62 loci and reveals novel systemic effects of LPA
  4. 4104
    por Burau, V.
    Publicado 2016
    “…These are variations of the path dependency argument and studies include both sector specific and broader political and administrative institutions. …”
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    Comparing medicine and management: methodological issues
  5. 4105
    “…These results pose a strong argument that the developed formulations can be explored as a promising carrier for treating leprosy with an innovative approach to target DAP directly to M-cells.…”
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    Design and statistical modeling of mannose-decorated dapsone-containing nanoparticles as a strategy of targeting intestinal M-cells
  6. 4106
    “…However, notwithstanding this logical argument, a better understanding of the biochemical, genetic, and molecular measures by which plants develop glyphosate resistance and how e[CO(2)] affects these measures will be important before attempting to innovate sustainable technology to manage the glyphosate-resistant evolution of weeds under e[CO(2)]. …”
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    Glyphosate Resistance of C(3) and C(4) Weeds under Rising Atmospheric CO(2)
  7. 4107
    “…Therefore, we conducted the first meta-analysis to provide a more persuasive argument to this debate. METHODS: In the current meta-analysis, based on ten prospective studies involving 29366 participants, we evaluated the role of urinary tubular injury markers (NGAL, KIM-1 and NAG) in predicting clinical outcomes including CKD stage 3, end stage renal disease and mortality. …”
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    Are Urinary Tubular Injury Markers Useful in Chronic Kidney Disease? A Systematic Review and Meta Analysis
  8. 4108
    “…Our observations provide a strong argument to plea for further global source-directed measures to reduce human exposure further to dioxin-like compounds.…”
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    WHO/UNEP global surveys of PCDDs, PCDFs, PCBs and DDTs in human milk and benefit–risk evaluation of breastfeeding
  9. 4109
    “…BACKGROUND: Brain-derived neurotrophic factor (BDNF) exerts beneficial effects not only on diabetic neuropathies but also on cardiovascular injury. There is argument regarding the levels of serum BDNF in patients with diabetes mellitus (DM). …”
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    Advanced glycation end products induce brain-derived neurotrophic factor release from human platelets through the Src-family kinase activation
  10. 4110
    “…It is currently held that glyphosate efficiently controls the obligate holoparasite Phelipanche aegyptiaca (Egyptian broomrape) by inhibiting its endogenous shikimate pathway, thereby causing a deficiency in aromatic amino acids (AAA). While there is no argument regarding the shikimate pathway being the primary site of the herbicide's action, the fact that the parasite receives a constant supply of nutrients, including proteins and amino acids, from the host does not fit with an AAA deficiency. …”
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    Secondary Effects of Glyphosate Action in Phelipanche aegyptiaca: Inhibition of Solute Transport from the Host Plant to the Parasite
  11. 4111
    por Lubbe, Welma, ten Ham-Baloyi, Wilma
    Publicado 2017
    “…In such situations the use of pacifiers can be considered therapeutic and even provide medical benefits to infants, including reducing the risk of sudden infant death syndrome. The argument opposing pacifier use, however, is based on potential risks such as nipple confusion and early cessation of breastfeeding. …”
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    When is the use of pacifiers justifiable in the baby-friendly hospital initiative context? A clinician’s guide
  12. 4112
    “…Results also indicated that repeating complement clauses put NT participants in a dual task whereas repeating relative clauses did not, suggesting that repeating relatives is easier for NT than repeating complements. This could be an argument in favor of the Misrepresentation account. …”
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    Role of Two Types of Syntactic Embedding in Belief Attribution in Adults with or without Asperger Syndrome
  13. 4113
    “…The collection of additional empirical data is deemed necessary by the nature and degree of adaptations to the EBI and the context. Our argument in this paper is conceptual, and we propose formal empirical tests of mediational equivalence in a follow-up paper.…”
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    “Scaling-out” evidence-based interventions to new populations or new health care delivery systems
  14. 4114
    por Simpson, J. Keith
    Publicado 2017
    “…Using appeal to fear as a tool of persuasion can be valid or fallacious depending on the truth of the premises within the argument. When used to raise awareness about genuine health concerns such as smoking, drunk driving and hypertension appeal to fear is considered to be a valid approach with certain caveats. …”
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    Appeal to fear in health care: appropriate or inappropriate?
  15. 4115
    “…RESULTS: The two-factor model, identifying personal consequences (had a hangover; got nauseated or vomited; missed a class) and social consequences (got into an argument or fight; been criticized by someone I know; done something I later regretted; been hurt or injured) was indicated to be the best model, having both a good model fit and an acceptable composite reliability. …”
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    The psychometric properties of a shortened Dutch version of the consequences scale used in the Core Alcohol and Drug Survey
  16. 4116
    por Manzo, Ciro, Natale, Maria
    Publicado 2017
    “…The lack of important data (genetic factors, hormonal dosages, serum levels of IL-6 and/or serum soluble IL-6 receptor) in our case-series represented important limits for clarifying the nature of our observations and should be included in any subsequent study design on this argument. If our monocentric data are confirmed by multicentric data, the assessment of the risk of falls through specific scales should be an integral part of the visit of all PMR patients.…”
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    Relapse of polymyalgia rheumatica after a fall
  17. 4117
    “…Despite the retrospective design, this study provides an additional argument in favour of normothermic recirculation. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s12882-017-0805-1) contains supplementary material, which is available to authorized users.…”
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    Uncontrolled donation after circulatory death: comparison of two kidney preservation protocols on graft outcomes
  18. 4118
    “…DISCUSSION: If removal on demand of the syndesmotic screw is non-inferior to routine removal in terms of functional outcome, this will offer a strong argument to adopt this as standard practice of care. …”
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    Routine versus on demand removal of the syndesmotic screw; a protocol for an international randomised controlled trial (RODEO-trial)
  19. 4119
    “…However, quantitative analysis of effects of managerial changes is important and can provide additional argument in support of innovation. METHODS: We take advantage of a quasi-experimental setting and of a unique administrative data set on the population of hospital discharge charts (HDCs) over a period of 9 years of Lombardy, the richest and one of the most populated region of Italy. …”
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    Evaluating organizational change in health care: the patient-centered hospital model
  20. 4120
    “…Intraoperative evidence of a lack of motor responses to direct electrical stimulation (DES) of Broca’s area and the observation that its stimulation induces a “speech arrest” without an apparent effect on the ongoing activity of phono-articulatory muscles, raises the argument. Essentially, attribution of direct involvement of Broca’s area in motor control of speech, requires evidence of a functional connection of this area with the phono-articulatory muscles’ motoneurons. …”
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    Broca’s Area as a Pre-articulatory Phonetic Encoder: Gating the Motor Program
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