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  1. 4281
    “…We also illustrate the consequences of using a confidence interval argument to inflate estimates so the required power is achieved with a pre-specified level of confidence. …”
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    Sample size requirements to estimate key design parameters from external pilot randomised controlled trials: a simulation study
  2. 4282
    “…It has several unique design features: (1) leveraging syntactic variations possible in a language and automatically generating extraction patterns in a systematic manner, (2) applying sentence simplification to improve the coverage of extraction patterns, and (3) identifying referential relations between a syntactic argument of a predicate and the actual target expected in the relation extraction task. …”
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    A generalizable NLP framework for fast development of pattern-based biomedical relation extraction systems
  3. 4283
    por Kohen, Amnon
    Publicado 2014
    “…Another source of perhaps nonsubstantial argument might stem from the varying time scales of enzymatic motions, which range from seconds to femtoseconds. …”
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    Role of Dynamics in Enzyme Catalysis: Substantial versus Semantic Controversies
  4. 4284
    “…CONCLUSIONS: While the main argument for excluding papers reporting case studies and case series in systematic literature reviews is that they are not of sufficient quality or generalizability, we found that they provided a more detailed account of how various chronic care models were developed and implemented. …”
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    Effectiveness of chronic care models: opportunities for improving healthcare practice and health outcomes: a systematic review
  5. 4285
    “…CONCLUSIONS: The lower direct costs of using Aprokam compared with purchased PFS presents a strong argument for the adoption of Aprokam where purchased PFS is administered. …”
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    Budget impact assessment of Aprokam® compared with unlicensed cefuroxime for prophylaxis of post-cataract surgery endophthalmitis
  6. 4286
    Publicado 2015
    “…This study adds compelling evidence to the argument for policies that improve access to care and provide adequate financial protection from the costs of illness. …”
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    Catastrophic health expenditure and 12-month mortality associated with cancer in Southeast Asia: results from a longitudinal study in eight countries
  7. 4287
    “…RESULTS: Nineteen studies from 23 papers were included. A line of argument synthesis was articulated around three third-order constructs: 1) Encounters with complexity; 2) Marshalling medicines, emotions, and resources; and 3) Self-preservation and prevention. …”
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    Living with complexity; marshalling resources: a systematic review and qualitative meta-synthesis of lived experience of mental and physical multimorbidity
  8. 4288
    “…BACKGROUND: To determine whether the public and scientists consider common arguments (and counterarguments) in support (or not) of animal research (AR) convincing. …”
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    The ethics of animal research: a survey of the public and scientists in North America
  9. 4289
    “…Together with the demonstrated impact of rotavirus vaccine in reducing population hospitalization burden, its cost-effectiveness makes a strong argument for widespread utilization in other low-income, high-burden settings.…”
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    Cost-Effectiveness of Monovalent Rotavirus Vaccination of Infants in Malawi: A Postintroduction Analysis Using Individual Patient–Level Costing Data
  10. 4290
    “…To address these gaps in training and funding, we argue that exposing students to pain science early in their careers, at the undergraduate level, may be an effective method to develop a pipeline for future pain clinicians and scientists. To highlight our argument, we will describe our recent successful implementation of a cross-disciplinary and community-engaged biomedical summer research program. …”
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    Summer undergraduate research: A new pipeline for pain clinical practice and research
  11. 4291
    “…The self-management model of care is now integral to the care of patients with chronic pain; home-based interventions can be very acceptable, making a compelling argument for investigating brief, self-management interventions. …”
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    Pilot study evaluating a brief mindfulness intervention for those with chronic pain: study protocol for a randomized controlled trial
  12. 4292
    “…However, we argue that their respective strengths and weaknesses can be complementary. We illustrate our argument from a recent study assessing the effect of telemonitoring on health-related quality of life, self-care, hospital use, costs and the experiences of patients, informal carers and health care professionals in two urban hospital services and one remote rural primary care service in New Zealand. …”
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    Should we embed randomized controlled trials within action research: arguing from a case study of telemonitoring
  13. 4293
    “…This finding strengthens the argument for NO(2) having a causal role in health effects.…”
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    Distinguishing the associations between daily mortality and hospital admissions and nitrogen dioxide from those of particulate matter: a systematic review and meta-analysis
  14. 4294
    por Centurión, Osmar Antonio
    Publicado 2016
    “…Although the cumulative evidence makes a strong argument for the use of bivalirudin rather than heparin plus systematic GP IIb/IIIa inhibitors for the great majority of patients with acute myocardial infarction (AMI) undergoing PCI, the benefit observed with bivalirudin was achieved because of the major bleeding complications with the use of heparin plus GP IIb/IIIa inhibitors. …”
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    Heparin Versus Bivalirudin in Acute Myocardial Infarction: Unfractionated Heparin Monotherapy Elevated to Primary Treatment in Contemporary Percutaneous Coronary Intervention
  15. 4295
    “…The purpose here is to present a protocol for a prospective longitudinal study: The Sports-Related Injuries and Illnesses in Paralympic Sport Study (SRIIPSS). METHODS/DESIGN: An argument-based method for investigation of design problems was used to structure the study protocol. …”
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    The Sports-Related Injuries and Illnesses in Paralympic Sport Study (SRIIPSS): a study protocol for a prospective longitudinal study
  16. 4296
    “…CONCLUSIONS: This study supports the argument that it is safe to offer video-assisted consultations for selected orthopaedic patients. …”
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    Quality of care for remote orthopaedic consultations using telemedicine: a randomised controlled trial
  17. 4297
    “…This explanation has been challenged by a recent article putting forth the argument that case misclassification is likely to have biased the odds ratios of the case–control studies that have investigated the association between CMT and vertebral artery related stroke. …”
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    Does case misclassification threaten the validity of studies investigating the relationship between neck manipulation and vertebral artery dissection stroke? No
  18. 4298
    “…The differences in data gaps and in hazard profiles support the argument that each silver form should be considered unique and subjected to hazard assessment to inform regulatory decisions and decisions about product design and development. …”
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    Use of a modified GreenScreen tool to conduct a screening-level comparative hazard assessment of conventional silver and two forms of nanosilver
  19. 4299
    “…We found that the PVT1 isoform harbouring the binding site for a representative miRNA of the miR-200 family shows a drastic decrease in its relative concentration with respect to the miRNA abundance in breast cancer tissues, providing a plausibility argument to the breakdown of the sponge program orchestrated by the oncogene PVT1.…”
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    Role of the long non-coding RNA PVT1 in the dysregulation of the ceRNA-ceRNA network in human breast cancer
  20. 4300
    “…BACKGROUND: Public health strategies are needed to curb antimalarial drug resistance. Theoretical argument points to an association between malaria transmission and drug resistance although field evidence remains limited. …”
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    Association of house spraying with suppressed levels of drug resistance in Zimbabwe
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