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1por Shirakami, Yoshifumi, Watabe, Tadashi, Obata, Honoka, Kaneda, Kazuko, Ooe, Kazuhiro, Liu, Yuwei, Teramoto, Takahiro, Toyoshima, Atsushi, Shinohara, Atsushi, Shimosegawa, Eku, Hatazawa, Jun, Fukase, Koichi“…In this study, we developed a novel method wherein astatination was realized via the substitution of (211)At for a dihydroxyboryl group coupled to phenylalanine. [(211)At]4-astato-L-phenylalanine was obtained as the carrier-free product in aqueous medium in high radiochemical yields (98.1 ± 1.9%, n = 5). …”
Publicado 2021
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2por Hanaoka, Hirofumi, Ohshima, Yasuhiro, Suzuki, Hiroyuki, Sasaki, Ichiro, Watabe, Tadashi, Ooe, Kazuhiro, Watanabe, Shigeki, Ishioka, Noriko S.“…SIMPLE SUMMARY: To enhance the therapeutic effect of 2-(211)At-astato-α-methyl-L-phenylalanine (2-(211)At-AAMP), a radiopharmaceutical for targeted alpha therapy, we evaluated the effect of probenecid loading on its biodistribution and therapeutic effect in mice. …”
Publicado 2021
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3“…In this study, we have evaluated the in vitro and in vivo properties of 3-[211At]astato-4-fluorobenzylguanidine ([211At]AFBG). The specific binding of [211At]AFBG to SK-N-SH human neuroblastoma cells remained fairly constant over 2- to 3-log activity range and was similar to that of [131I]MIBG. …”
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4por Ohshima, Yasuhiro, Sudo, Hitomi, Watanabe, Shigeki, Nagatsu, Kotaro, Tsuji, Atsushi B., Sakashita, Tetsuya, Ito, Yoichi M., Yoshinaga, Keiichiro, Higashi, Tatsuya, Ishioka, Noriko S.“…A new generation of radionuclides for therapy using α-particles including meta-(211)At-astato-benzylguanidine ((211)At-MABG) are expected to have strong therapeutic effects with minimal side effects. …”
Publicado 2018
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5por Ukon, Naoyuki, Higashi, Tatsuya, Hosono, Makoto, Kinuya, Seigo, Yamada, Takahiro, Yanagida, Sachiko, Namba, Masao, Nakamura, YoshihideEnlace del recurso
Publicado 2022
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6por Ohshima, Yasuhiro, Kono, Nobuaki, Yokota, Yuichiro, Watanabe, Shigeki, Sasaki, Ichiro, Ishioka, Noriko S., Sakashita, Tetsuya, Arakawa, Kazuharu“…Recent observations regarding meta-(211)At-astato-benzylguanidine ((211)At-MABG) in a pheochromocytoma mouse model showed a strong anti-tumor effect, though the molecular mechanism remains elusive. …”
Publicado 2019
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7por Yoshinaga, Keiichiro, Zhao, Songji, Washino, Komei, Aoki, Miho, Nishijima, Ken-ichi, Shimoyama, Saki, Ukon, Naoyuki, Gao, Fengying, Washiyama, Kohshin, Ito, Natsue, Yoshioka, Naho, Tamura, Naomi, Takahashi, Kazuhiro, Ito, Hiroshi, Higashi, Tatsuya“…In theory, the alpha-emitting radiopharmaceutical meta-(211)At-astato-benzylguanidine ((211)At-MABG) could be a very effective targeted treatment for metastatic PPGL. …”
Publicado 2020
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8por Abuelatta, Reda, Sakrana, Amal A., Al-zubaidi, Shadha A., Abdelhalim, Mohammed, Naeim, Hesham Abdo“…We applied a 50 Watt of energy via electrocautery pen to a Hi-Torque 0.014 Astato guidewire to cross the occluded segment retrogradely. …”
Publicado 2020
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9por Li, Yawen, Chyan, Ming-Kuan, Hamlin, Donald K., Nguyen, Holly, Corey, Eva, Wilbur, D. Scott“…Oxidization of the [(125)I]iodo- and [(211)At]astato-benzamidyl-dPEG(4)-acid methyl ester derivatives provided materials for in vivo evaluation. …”
Publicado 2022
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