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  1. 2361
    “…BACKGROUND: AURA study reported 61% objective response rate and progression-free survival of 9.6 months with osimertinib in patients with EGFR/T790M+ non-small cell lung cancer. …”
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    Osimertinib in advanced EGFR-T790M mutation-positive non-small cell lung cancer patients treated within the Special Use Medication Program in Spain: OSIREX-Spanish Lung Cancer Group
  2. 2362
    “…BACKGROUND: Approximately half of all patients with advanced EGFR-mutant NSCLC will develop acquired resistance to first or second-generation EGFR tyrosine kinase inhibitors (EGFR-TKIs) with a T790M mutation. In the AURA3 trial, patients with a T790M mutation had a response rate of 71% to osimertinib, a third-generation EGFR-TKI. …”
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    Plasma pre-treatment T790M relative allelic frequency in patients with advanced EGFR-mutated non-small cell lung cancer predicts treatment response to subsequent-line osimertinib
  3. 2363
    “…The multivariate stepwise linear regression analysis of changes in the total MIDAS score before and during the first wave of COVID-19 pandemic identified worsened sleep, increased acute medication use, increased stress, medication shortages, comorbidities, the absence of an aura and new-onset headache were determinants of an increased total MIDAS score during the first wave of the COVID-19 pandemic. …”
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    Impact of the COVID-19 pandemic on migraine in Japan: a multicentre cross-sectional study
  4. 2364
    “…METHODS: We investigated, using diffusion-weighted MRI imaging tractography-based graph analysis, the graph-topological indices of the brain “connectome”, a set of grey matter regions (nodes) structurally connected by white matter paths (edges) in 94 patients with migraine without aura compared to 91 healthy controls. RESULTS: We observed in migraine patients compared to healthy controls: i) higher local and global network efficiency (p < 0.001) and ii) higher local and global clustering coefficient (p < 0.001). …”
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    Disconnectome of the migraine brain: a “connectopathy” model
  5. 2365
    “…METHODS: Twenty patients with VSS were compared to age-, gender-, migraine- and aura-matched controls in this case-control study. …”
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    Age- and frequency-dependent changes in dynamic contrast perception in visual snow syndrome
  6. 2366
    “…METHODS: Data included in the NMA were identified through a systematic literature search (conducted April 2018, updated May/December 2020) of phase II–IV, randomised controlled trials (RCTs) in adults with chronic/episodic migraine with/without aura. Treatments included: lasmiditan 50, 100, 200 mg; rimegepant 75 mg; ubrogepant 25, 50, 100 mg. …”
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    Relative efficacy of lasmiditan versus rimegepant and ubrogepant as acute treatments for migraine: network meta-analysis findings
  7. 2367
    por Patel, Toral, Arora, Gunjan
    Publicado 2022
    “…It may be preceded by aura continua, non-motor manifestations such as tingling and numbness, and followed by Todd's phenomenon, transient unilateral weakness. …”
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    ODP194 EPC (Epilepsia Partialis Continue)- as a presenting symptom of HHS (Hyperglycemic Hyperosmolar Syndrome)
  8. 2368
    “…BACKGROUND: Observational studies on the prevalence of premonitory symptoms in people with migraine, preceding the headache pain (or aura) phase, have shown conflicting results. We conducted a systematic review and meta-analysis to estimate the prevalence, and relative frequency among clinic populations, of premonitory symptoms in people with migraine, overall and of the multifarious individual symptoms, and to review the methodologies used to assess them. …”
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    Premonitory symptoms in migraine: a systematic review and meta-analysis of observational studies reporting prevalence or relative frequency
  9. 2369
    “…METHODS: We will study a cohort of 180 adolescents, ages 11–17 years, with migraine (with or without aura, chronic migraine) and comorbid insomnia. In phase 1, youth will be randomly assigned to receive Internet-delivered CBT-I intervention or Internet sleep education control. …”
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    Intervention for Sleep and Pain in Youth (ISPY-RCT): protocol for a two-phase randomized controlled trial of sequenced cognitive-behavioral therapy for insomnia and pain management in adolescents with migraine
  10. 2370
    “…METHODS: In this double-blind, placebo-controlled, parallel-group study in adults with a history of migraine with or without aura, participants were randomized via computer-generated lists to AVP-825 or placebo device to treat a single migraine headache of moderate or severe intensity. …”
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    A Randomized, Double-Blind, Placebo-Controlled Study of Breath Powered Nasal Delivery of Sumatriptan Powder (AVP-825) in the Treatment of Acute Migraine (The TARGET Study)
  11. 2371
    “…We report a case of a 71-year-old female with a history of CABG 10 years ago, who presented to the emergency department with a syncopal episode. The patient denied aura, vomiting, jerky movements, rolling eye movements, bowel/bladder incontinence, and palpitations. …”
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    SAT-460 Myxedema Coma Mimicking Cardiogenic Shock Treated with Levothyroxine
  12. 2372
    “…The ACHIEVE I and II trials were 2 multicenter, single‐attack, randomized, Phase 3 trials in adults with a history of migraine with or without aura. Participants had the option to take a second dose of study medication or rescue medication to treat a nonresponding migraine or a migraine recurrence from 2 to 48 hours after the initial dose of study medication. …”
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    Evaluation of the Pharmacokinetic Interaction of Ubrogepant Coadministered With Sumatriptan and of the Safety of Ubrogepant With Triptans
  13. 2373
    “…RESULTS: Plasma concentrations of the most Trp metabolites were remarkably decreased in the interictal period of migraineurs compared to healthy control subjects, especially in the migraine without aura (MWoA) subgroup: Trp (p < 0.025), L-kynurenine (p < 0.001), kynurenic acid (p < 0.016), anthranilic acid (p < 0.007), picolinic acid (p < 0.03), 5-hydroxy-indoleaceticacid (p < 0.025) and melatonin (p < 0.023). …”
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    Clinical relevance of depressed kynurenine pathway in episodic migraine patients: potential prognostic markers in the peripheral plasma during the interictal period
  14. 2374
    “…METHODS: A total of 70 patients diagnosed with migraine without aura (MWoA) and 70 matched healthy controls were recruited to complete fMRI scanning. …”
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    Predicting response to tVNS in patients with migraine using functional MRI: A voxels-based machine learning analysis
  15. 2375
    “…Conclusion: Les premiers commentaires des directeurs de district indiquent que quand on emploie des médecins de famille qui ont la possibilité de fonctionner d'une manière optimale, ils ont un impact important sur la performance du système de santé et la qualité du processus clinique. Cela aura probablement un impact sur la santé, à long terme.…”
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    Assessment of the impact of family physicians in the district health system of the Western Cape, South Africa
  16. 2376
    “…Respondents reported limitations completing daily activities during all migraine phases, including during the premonitory/aura and postdrome phases. Most (761/1101 (69%)) relied on family, friends, or others for help with daily tasks and reported being helped a median of 9 days (25th percentile 5 days, 75th percentile 15 days) within the last 3 months. …”
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    United States Patients’ Perspective of Living With Migraine: Country‐Specific Results From the Global “My Migraine Voice” Survey
  17. 2377
    “…MOH was present in 70% of patients, and 17.1% had migraine with aura. Patients had failed a mean of 7.8 preventive treatments at baseline (botulinum toxin type A—BoNT/A—had been used by 95.2% of patients). …”
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    MAB-MIG: registry of the spanish neurological society of erenumab for migraine prevention
  18. 2378
    por Li, Zhe-Yuan, Si, Li-Hong, Shen, Bo, Yang, Xu
    Publicado 2021
    “…The migraine-like symptoms were photophobia or phonophobia (n = 15, 88.2%), migraine-like headache (n = 8, 47.1%), visual aura during VM onset (n = 7, 41.2%). 5 (29.4%) patients with VM had hyperactive response during the caloric test, and 12 (70.6%) patients had caloric test intolerance. …”
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    Altered brain network functional connectivity patterns in patients with vestibular migraine diagnosed according to the diagnostic criteria of the Bárány Society and the International Headache Society
  19. 2379
    “…CONCLUSION: Il s’agit du premier cluster large documenté en France qui aura été remarquable par le nombre élevé de cas dans l’environnement confiné du chalet (au 16/02, n = 13 : 1 cas index, 11 cas secondaires et 1 cas tertiaire), le nombre important de sujets contacts suivis, et son caractère international (3 pays concernés).…”
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    Cas groupés d’infections au nouveau coronavirus (SARS-CoV-2) aux Contamines-Montjoie, Haute-Savoie, janvier–février 2020
  20. 2380
    por Menard, A., Chine, M., Meddeb, L., Rossi, P.
    Publicado 2022
    “…. =1/(1+(EXP((-1)*((-2,745)+(-0,329)*Femme+0,005*AgeQuantitatif +0,589*ambulatoire +(-0,418)*FDR-HCSP+0,9*Symptômes<5+(0,181)*Borg > 3+0,263*mMRC > 1+1,694*Pichot > 20+1,72*anosmie/agueusie+1,799*DifficultésCognitives+1,766*SymptomesPsychiatriques+2,008*DiagnosticDifferentiel))) CONCLUSION: Ce score, apres une validation externe, nous permettra d'évaluer le pourcentage de risque d'évoluer vers un COVID long qu'aura chaque patient d'après ses données du J0 et de sa première consultation post covid. …”
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    Du suivi Post-Covid au Covid-Long : Score pronostic à partir d'une prise en charge holistique
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