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    Benfluorex withdrawal in France: Still be hiding somewhere in the world?
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    “…BACKGROUND: Recent case reports suggest that benfluorex, a fenfluramine derivative used in the management of overweight diabetic patients and dyslipidemia, is associated with cardiac valve regurgitation. …”
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    Benfluorex and Unexplained Valvular Heart Disease: A Case-Control Study
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    “…There is a risk of misdiagnosis between benfluorex-induced VHD and acute rheumatic fever (ARF)-related VHD due to common characteristics of both etiologies. …”
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    Drug-Induced- or Rheumatic- Valvular Heart Disease in Patients Exposed to Benfluorex?
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    “…Patients exposed to benfluorex have an increased risk of restrictive organic valvular heart disease. …”
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    Sub-aortic obstruction of left ventricular outflow tract secondary to benfluorex-induced endocardial fibrosis
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    “…The patient had been exposed to benfluorex for 6.5 years. DIAGNOSES: The diagnostic procedure documented specific drug-induced valvular fibrosis. …”
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    Fatal postoperative systemic pulmonary hypertension in benfluorex-induced valvular heart disease surgery: A case report
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    “…OBJECTIVES: REGULATE trial was designed to compare the efficacy and safety of benfluorex versus pioglitazone in type 2 diabetes mellitus (DM) patients. …”
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    Echocardiographic Evidence for Valvular Toxicity of Benfluorex: A Double-Blind Randomised Trial in Patients with Type 2 Diabetes Mellitus
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    “…CASE SUMMARY: We report two patients with a history of benfluorex administration, who developed extensive mitral calcific lesions which evolved towards caseous necrosis. …”
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    Caseous necrosis of the mitral annulus: a new feature of drug-induced valvular heart disease? Case series
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    “…Dans tous ces domaines, cette 8e édition rend compte de l'actualité du droit du dommage corporel : jurisprudence détaillée sur la nomenclature des préjudices réparables, à l'heure où sa consécration par décret reste en suspens, évaluation médicale et monétaire des préjudices, actualité jurisprudentielle du recours des tiers payeurs (article 25 de la loi du 21 décembre 2006 et ses difficultés d'application), sécurité sociale, responsabilité médicale et indemnisations des victimes d'accidents médicaux après plus de dix ans d'application de la loi du 4 mars 2002, indemnisation des victimes du Benfluorex, accidents de la circulation et de transports collectifs de personnes, violence et terrorisme... …”
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    Droit du dommage corporel: systèmes d'indemnisation
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    “…NCT was identified by structural similarity to previously the previously identified but weak HNF4α agonists alverine and benfluorex. Here, we administered NCT to mice fed a high fat diet, with the goal of studying the role of HNF4α in obesity-related diseases. …”
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    A potent HNF4α agonist reveals that HNF4α controls genes important in inflammatory bowel disease and Paneth cells
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    “…We performed a network meta-analysis to compare the efficacy of 12 single-drug regimens (Glibenclamide, Glimepiride, Pioglitazone, Rosiglitazone, Repaglinide, Metformin, Sitaglitin, Exenatide, Liraglutide, Acarbose, Benfluorex, and Glipizide) in the treatment of type 2 diabetes mellitus (T2DM). …”
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    Comparison of twelve single-drug regimens for the treatment of type 2 diabetes mellitus
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    “…Meanwhile, hnf4α overexpression enhanced LC-PUFA biosynthesis in SCHL cell, and intraperitoneal injection to rabbitfish juveniles with Hnf4α agonists (Alverine and Benfluorex) increased the expression of hnf4α, elvol5 and Δ4 fad, coupled with an increased proportion of total LC-PUFA in liver. …”
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    Hnf4α Is Involved in LC-PUFA Biosynthesis by Up-Regulating Gene Transcription of Elongase in Marine Teleost Siganus canaliculatus
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    “…The HNF4α activators are N-trans caffeoyltyramine (NCT) and N-trans feruloyltyramine (NFT), which are structurally related to the known drugs alverine and benfluorex, which we previously showed to be weak HNF4α activators. …”
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    Liver fat storage is controlled by HNF4α through induction of lipophagy and is reversed by a potent HNF4α agonist
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    “…We hypothesized that such policies may have been introduced following a 2009–2010 drug safety scandal (benfluorex, Mediator) in which COIs in medicine received prominent press attention. …”
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    Conflict of Interest Policies at French Medical Schools: Starting from the Bottom
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    “…Since the 1960s, several drugs have been linked to the onset or aggravation of pulmonary arterial hypertension (PAH): dasatinib, some amphetamine‐like appetite suppressants (aminorex, fenfluramine, dexfenfluramine, benfluorex) and recreational drugs (methamphetamine). …”
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    Identifying new drugs associated with pulmonary arterial hypertension: A WHO pharmacovigilance database disproportionality analysis
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