Mitochondrial protein import clogging as a mechanism of disease

por Coyne, Liam P, Wang, Xiaowen, Song, Jiyao, de Jong, Ebbing, Schneider, Karin, Massa, Paul T, Middleton, Frank A, Becker, Thomas, Chen, Xin Jie
Publicado 2023

Improved isolation of extracellular vesicles by removal of both free proteins and lipoproteins

por Ter-Ovanesyan, Dmitry, Gilboa, Tal, Budnik, Bogdan, Nikitina, Adele, Whiteman, Sara, Lazarovits, Roey, Trieu, Wendy, Kalish, David, Church, George M, Walt, David R
Publicado 2023

An acetylation-mediated chromatin switch governs H3K4 methylation read-write capability

por Jain, Kanishk, Marunde, Matthew R, Burg, Jonathan M, Gloor, Susan L, Joseph, Faith M, Poncha, Karl F, Gillespie, Zachary B, Rodriguez, Keli L, Popova, Irina K, Hall, Nathan W, Vaidya, Anup, Howard, Sarah A, Taylor, Hailey F, Mukhsinova, Laylo, Onuoha, Ugochi C, Patteson, Emily F, Cooke, Spencer W, Taylor, Bethany C, Weinzapfel, Ellen N, Cheek, Marcus A, Meiners, Matthew J, Fox, Geoffrey C, Namitz, Kevin EW, Cowles, Martis W, Krajewski, Krzysztof, Sun, Zu-Wen, Cosgrove, Michael S, Young, Nicolas L, Keogh, Michael-Christopher, Strahl, Brian D
Publicado 2023

Pharmacological hallmarks of allostery at the M4 muscarinic receptor elucidated through structure and dynamics

por Vuckovic, Ziva, Wang, Jinan, Pham, Vi, Mobbs, Jesse I, Belousoff, Matthew J, Bhattarai, Apurba, Burger, Wessel AC, Thompson, Geoff, Yeasmin, Mahmuda, Nawaratne, Vindhya, Leach, Katie, van der Westhuizen, Emma T, Khajehali, Elham, Liang, Yi-Lynn, Glukhova, Alisa, Wootten, Denise, Lindsley, Craig W, Tobin, Andrew, Sexton, Patrick, Danev, Radostin, Valant, Celine, Miao, Yinglong, Christopoulos, Arthur, Thal, David M
Publicado 2023

The RNA helicase DDX39B activates FOXP3 RNA splicing to control T regulatory cell fate

por Hirano, Minato, Galarza-Muñoz, Gaddiel, Nagasawa, Chloe, Schott, Geraldine, Wang, Liuyang, Antonia, Alejandro L, Jain, Vaibhav, Yu, Xiaoying, Widen, Steven G, Briggs, Farren BS, Gregory, Simon G, Ko, Dennis C, Fagg, William S, Bradrick, Shelton, Garcia-Blanco, Mariano A
Publicado 2023

Decoding the mechanisms of allostery

por Khan, Saif, Gati, Cornelius
Publicado 2023

The Mechanosensitive Piezo1 Channel Mediates Mechanochemical Transmission in Myopic Eyes

por Zhong, Weiqi, Lan, Changjun, Gu, Zhiming, Tan, Qingqing, Xiang, Xiaoling, Zhou, Hong, Liao, Xuan
Publicado 2023

HSF4 Transcriptionally Activates Autophagy by Regulating ATG9a During Lens Terminal Differentiation

por Zhang, Jing, Jiang, Ning, Du, Chunxiao, Guo, Hongzan, Meng, Ranqi, Hou, Xinyu, Liu, Mugen, Hu, Yanzhong, Cui, Xiukun
Publicado 2023

Selective BD2 Inhibitor Exerts Anti-Fibrotic Effects via BRD4/FoxM1/Plk1 Axis in Orbital Fibroblasts From Patients With Thyroid Eye Disease

por Xie, Yanyan, Pan, Yuan, Chen, Qian, Chen, Yuxi, Chen, Guanyu, Wang, Mei, Zeng, Peng, Li, Zhuang, Li, Zuoyi, Wang, Sha, Yang, Huasheng, Liang, Dan
Publicado 2023

The structural basis of the multi-step allosteric activation of Aurora B kinase

por Segura-Peña, Dario, Hovet, Oda, Gogoi, Hemanga, Dawicki-McKenna, Jennine, Hansen Wøien, Stine Malene, Carrer, Manuel, Black, Ben E, Cascella, Michele, Sekulic, Nikolina
Publicado 2023

Alternative activation

por Young, Kristen, Fanning, Sean
Publicado 2023

Molecular basis of ligand-dependent Nurr1-RXRα activation

por Yu, Xiaoyu, Shang, Jinsai, Kojetin, Douglas J
Publicado 2023

Pancreatic tumors exhibit myeloid-driven amino acid stress and upregulate arginine biosynthesis

por Apiz Saab, Juan J, Dzierozynski, Lindsey N, Jonker, Patrick B, AminiTabrizi, Roya, Shah, Hardik, Menjivar, Rosa Elena, Scott, Andrew J, Nwosu, Zeribe C, Zhu, Zhou, Chen, Riona N, Oh, Moses, Sheehan, Colin, Wahl, Daniel R, Pasca di Magliano, Marina, Lyssiotis, Costas A, Macleod, Kay F, Weber, Christopher R, Muir, Alexander
Publicado 2023

Optical tools for visualizing and controlling human GLP-1 receptor activation with high spatiotemporal resolution

por Duffet, Loïc, Williams, Elyse T, Gresch, Andrea, Chen, Simin, Bhat, Musadiq A, Benke, Dietmar, Hartrampf, Nina, Patriarchi, Tommaso
Publicado 2023

Ribozyme activity modulates the physical properties of RNA–peptide coacervates

por Le Vay, Kristian Kyle, Salibi, Elia, Ghosh, Basusree, Tang, TY Dora, Mutschler, Hannes
Publicado 2023

Calcium and bicarbonate signaling pathways have pivotal, resonating roles in matching ATP production to demand

por Greiser, Maura, Karbowski, Mariusz, Kaplan, Aaron David, Coleman, Andrew Kyle, Verhoeven, Nicolas, Mannella, Carmen A, Lederer, W Jonathan, Boyman, Liron
Publicado 2023

Autophagosome membrane expansion is mediated by the N-terminus and cis-membrane association of human ATG8s

por Zhang, Wenxin, Nishimura, Taki, Gahlot, Deepanshi, Saito, Chieko, Davis, Colin, Jefferies, Harold BJ, Schreiber, Anne, Thukral, Lipi, Tooze, Sharon A
Publicado 2023

SIMMER employs similarity algorithms to accurately identify human gut microbiome species and enzymes capable of known chemical transformations

por Bustion, Annamarie E, Nayak, Renuka R, Agrawal, Ayushi, Turnbaugh, Peter J, Pollard, Katherine S
Publicado 2023

Phase separation-mediated actin bundling by the postsynaptic density condensates

por Chen, Xudong, Jia, Bowen, Zhu, Shihan, Zhang, Mingjie
Publicado 2023

Determinants of sugar-induced influx in the mammalian fructose transporter GLUT5

por McComas, Sarah E, Reichenbach, Tom, Mitrovic, Darko, Alleva, Claudia, Bonaccorsi, Marta, Delemotte, Lucie, Drew, David
Publicado 2023